Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 3, 2024
Cancer
metastasis
remains
a
critical
factor
contributing
to
the
current
limitations
in
cancer
treatment.
Photothermal
immunotherapy
has
emerged
as
safe
and
potent
therapeutic
approach,
demonstrating
capability
suppress
tumor
growth
metastasis.
While
researchers
have
extensively
investigated
various
structural
modifications
enhance
photothermal
conversion
performance,
influence
of
molecular
configuration
received
comparatively
limited
attention.
In
this
study,
we
synthesized
two
isomers,
CZTBT
LVTBT,
which
possessed
distinct
configurations.
characterized
by
flatter
configuration,
exhibited
an
extended
absorption
wavelength
higher
molar
extinction
coefficient.
Its
excited
state
facilitated
stronger
rotation
for
non-radiative
transitions,
leading
high
efficiency
(PCE)
36.3
%.
When
combined
with
R848,
LVTBT@R848
nanoparticles
(NPs)-mediated
functioned
situ
vaccine,
promoting
maturation
dendritic
cells
(DCs),
T
cell
infiltration,
differentiation
natural
killer
(NK)
memory
cells,
thereby
activating
strong
immune
response.
Consequently,
it
significantly
inhibited
both
primary
distant
tumors,
while
also
limiting
lung
summary,
study
proposed
configuration-mediated
transition
strategy
efficient
immunotherapy,
advancing
frontiers
organic
agents
(OPTAs)
design
synthesis.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 23, 2024
Low-intensity
ultrasound-mediated
sonodynamic
therapy
(SDT),
which,
by
design,
integrates
sonosensitizers
and
molecular
oxygen
to
generate
therapeutic
substances
(e.g.,
toxic
hydroxyl
radicals,
superoxide
anions,
or
singlet
oxygen)
at
disease
sites,
has
shown
enormous
potential
for
the
effective
treatment
of
a
variety
diseases.
Nanoscale
play
crucial
role
in
SDT
process
because
their
structural,
compositional,
physicochemical,
biological
characteristics
are
key
determinants
efficacy.
In
particular,
advances
materials
science
nanotechnology
have
invigorated
series
optimization
strategies
augmenting
efficacy
nanosonosensitizers.
This
comprehensive
review
systematically
summarizes,
discusses,
highlights
state-of-the-art
studies
on
current
achievements
nanosonosensitizer
enhanced
treatment,
with
an
emphasis
general
design
principles
nanosonosensitizers
strategies,
mainly
including
organic
inorganic
Additionally,
recent
advancements
optimized
applications
aimed
treating
various
diseases,
such
as
cancer,
bacterial
infections,
atherosclerosis,
autoimmune
clarified
detail.
Furthermore,
effects
improved
versatile
thoroughly
discussed.
The
concludes
highlighting
challenges
future
opportunities
this
rapidly
evolving
research
field
expedite
its
practical
clinical
translation
application.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
An
overview
of
cyanine
dye-based
phototherapy
agents,
including
the
design
strategies,
relationships
between
molecular
structures
and
properties,
as
well
applications
in
photodynamic
therapy,
photothermal
multimodal
combined
therapy.
Aggregate,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 18, 2024
ABSTRACT
Photodynamic
therapy
(PDT)
and
photothermal
(PTT)
have
emerged
promising
applications
in
both
fundamental
research
clinical
trials.
However,
it
remains
challenging
to
develop
ideal
photosensitizers
(PSs)
that
concurrently
integrate
high
photostability,
large
near‐infrared
absorptivity,
efficient
therapeutic
capabilities.
Herein,
we
reported
a
sample
engineering
strategy
afford
benzene‐fused
Cy5
dimer
(
Cy‐D‐5
)
for
synergistically
boosting
PDT/PTT
applications.
Intriguingly,
exhibits
tendency
form
J
‐aggregates
H
phosphate‐buffered
saline,
which
show
long‐wavelength
absorption
band
bathochromically
shifted
810
nm
short‐wavelength
hypsochromically
745
nm,
respectively,
when
compared
its
behavior
ethanol
(778
nm).
Density‐functional
theory
calculations
combined
with
time‐resolved
transient
optical
spectroscopy
analysis
reveal
the
fused
low
Δ
E
ST
(0.51
eV)
non‐radiative
transition
rates
(12.6
times
greater
than
of
clinically
approved
PS‐indocyanine
green
[PS‐
ICG
]).
Furthermore,
demonstrates
higher
photosensitizing
ability
produce
1
O
2
,
stronger
conversion
efficiency
η
=
64.4%),
photostability
.
These
properties
enable
achieve
complete
tumor
ablation
upon
808
laser
irradiation,
highlighting
potential
as
powerful
dual‐function
phototherapeutic
agent.
This
work
may
offer
practical
other
existing
dyes
red‐shifted
spectral
range
various
phototherapy
