Trends in Cell Biology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
ACS Nano, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 27, 2024
It has been nearly two decades since the term "protein corona" was coined. This evolved to "biomolecular or "biocorona" capture diverse biomolecules that spontaneously form on surface of nanoparticles upon exposure biological fluids and drive nanoparticle interactions with systems. In this Perspective, we highlight significant progress in field, including studies nonprotein corona components, lipid nanoparticles, role endogenous organ targeting. We also discuss research opportunities particularly need for improved characterization standardization analysis how recent advances artificial intelligence ex vivo models can improve our understanding biomolecular guiding nanomedicine design.
Language: Английский
Citations
4
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 14, 2025
Coacervation based on liquid-liquid phase separation (LLPS) has been widely used for the preparation of artificial protocells and to mimic dynamic organization membrane-free organelles. Most complex synthetic coacervates are formed through electrostatic interactions but cannot withstand high ionic strength conditions (>0.1 M). Alternative components driving forces highly desired formation natural organelles overcome drawbacks traditional coacervates. Herein, hydrogen bonding-driven adaptive reported via complexation poly(ethylene glycol) (PEG) tannic acid (TA). The LLPS behavior these is dependent concentration mass ratio PEG TA, which can be tune size ranging from 70 nm 10 μm as well morphology isotropic particles hollow capsules. Coacervates stable at concentrations up 1 M serve cellular behaviors including metabolism (e.g., nutrient uptake), phagocytosis, membrane fusion. approach provides a platform rational design with controllable morphology, offering potential applications in protocell construction therapeutic delivery.
Language: Английский
Citations
0
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 10, 2025
Castration-resistant prostate cancer (CRPC) is an intractable disease, but approaches for eradicating primary tumors and inhibiting metastasis are limited. Considering that lipid metabolism plays key roles in ferroptosis tumor progression treatment resistance, here we developed a biomimetic nanovesicle (FiFe@RBM) encapsulating fatty acid synthetase inhibitors iron oxide nanoparticles synergistic therapy of CRPC the metastasis. FiFe@RBM with superior magnetic properties efficiently delivered drugs into cells, where it can release Fe ions to induce reactive oxygen species mitochondrial dysfunction inhibit AKT-mTOR pathway, which synergistically causes apoptosis enhances by rewired through increasing polyunsaturated acids (PUFAs), PUFA-enriched phosphatidylcholine (PUFA-PC), phosphatidylethanolamine (PUFA-PE), etc. By intravenous injection, high accumulation PC-3 enabled precision T1/T2-weighted resonance imaging-guided effective eradication human hyperthermia (MHT) ferroptosis, further inhibited liver activated recruited rates natural killer cells nude mice model. This work presents strategy reprogramming enhance synergy MHT effectively treating refractory cancers.
Language: Английский
Citations
0
Clinical Pharmacology & Therapeutics, Journal Year: 2025, Volume and Issue: unknown
Published: March 14, 2025
The utilization of lipid nanoparticles (LNP) for encapsulating mRNA has revolutionized the field therapeutics, enabling rapid development COVID‐19 vaccines and cancer vaccines. However, clinical mRNA‐LNP therapeutics faces numerous challenges due to their complex mechanisms action limited experience. To overcome these hurdles, Model‐Informed Drug Development (MIDD) emerges as a valuable tool that can be applied facilitating evaluation safety efficacy through integration data from all stages into appropriate modeling simulation techniques. In this review, we provide an overview current MIDD applications in using vivo data. A variety methods are reviewed, including quantitative system pharmacology (QSP), physiologically based pharmacokinetics (PBPK), mechanistic pharmacokinetics/pharmacodynamics (PK/PD), population PK/PD, model‐based meta‐analysis (MBMA). Additionally, compare differences between mRNA‐based small interfering RNA, adeno‐associated virus‐based gene therapies terms pharmacology, discuss potential mutual sharing knowledge therapeutics. Furthermore, highlight promising future opportunities applying approaches drugs. By emphasizing importance throughout development, review aims encourage stakeholders recognize value its enhance
Language: Английский
Citations
0
Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 538, P. 216718 - 216718
Published: April 22, 2025
Language: Английский
Citations
0
Trends in Immunology, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0
Advanced Science, Journal Year: 2024, Volume and Issue: 12(2)
Published: Nov. 18, 2024
Abstract Phosphate and phosphonate drugs are vital in building organisms, regulating physiological processes, exhibiting diverse biological activities, including antiviral, antibacterial, antineoplastic, enzyme‐inhibitory effects. However, their therapeutic potential is limited by the lack of advanced nanoengineering technologies. Herein, a competitive coordination strategy for phosphate/phosphonate introduced. By leveraging difference capabilities between polyphenols phosphates/phosphonates with metal ions, various phosphate/phosphonate‐based nanodrugs using metal‐phenolic networks (MPNs) as templates agents constructed. The dynamic nature these bonds imparts stimuli‐responsiveness to nanodrugs, allowing targeted release therapy. As proof concept, Fe 3+ galangin used form MPN template, zoledronic acid cGAMP agents, DOX loaded drug construct DOX@Fe‐galangin@Fe‐zoledronic acid‐cGAMP nanodrugs. results demonstrate that, triggering pyroptosis activating cGAS‐STING pathway, exhibit potent cytotoxicity accurate selectivity eradicating orthotopic breast tumors, activate an antitumor immune response against lung bone metastases. Because applicable variety it holds significant enhancing clinical efficacy advancing nanodrug development complex applications.
Language: Английский
Citations
1
Trends in Cell Biology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
Citations
0