PdPt Bimetal-Functionalized SnO₂ Nanosheets: Controllable Synthesis and its Dual Selectivity for Detection of Carbon Monoxide and Methane

ACS Applied Materials & Interfaces, Journal Year: 2019, Volume and Issue: 11(29), P. 26116 - 26126

Published: July 2, 2019

Bimetallic nanoparticles (NPs) usually exhibit some novel properties due to the synergistic effects of two distinct metals, which is expected play an important role in field gas sensing. PdPt bimetal NPs with Pd-rich shell and Pt-rich core were successfully synthesized used modify SnO2 nanosheets. The 1P-PdPt/SnO2-A sensor obtained by self-assemblies exhibited temperature-dependent dual selectivity CO at 100 °C CH4 320 °C. Furthermore, possessed good long term stability antihumidity interference. activation energy adsorption for estimated response process modeled using Langmuir kinetics, proved that lower corresponded better sensing performance. gas-sensing mechanism based on diffusion depth tested layer was discussed. dramatically improved performance could be ascribed high catalytic activity bimetal, electron sensitization PdO, Schottky barrier-type junctions interface between NPs. Our present results demonstrate special structure components can significantly improve metal oxide semiconductor has great potential monitoring coal mine gas.

Language: Английский

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Toxicity of manufactured nanomaterials

Particuology, Journal Year: 2021, Volume and Issue: 69, P. 31 - 48

Published: Nov. 30, 2021

Manufactured nanomaterials with unique properties have been extensively applied in various industrial, agricultural or medical fields. However, some of the identified to be closely related nanomaterial toxicity. The "nano-paradox" has aroused concerns over use and development nanotechnology, which makes it difficult for regulatory agencies regulate nanomaterials. key fulfilling proper regulation lies adequate understanding impact on nano-bio interactions. To this end, we start present work a brief introduction interactions at different levels. Based that, how toxicity-associated manufactured (i.e., size, shape, chemical composition, surface properties, biocorona formation, agglomeration and/or aggregation state, biodegradability) their toxicokinetics, cellular uptake, trafficking responses, toxicity mechanisms is deeply explored. Moreover, advanced analytical methods studying are introduced. Furthermore, current legislative frameworks nanomaterial-containing products regions countries presented. Finally, propose several challenges facing nanotoxicology field possible solutions shed light safety evaluation

Language: Английский

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Nanomaterial-based CT contrast agents and their applications in image-guided therapy

Theranostics, Journal Year: 2022, Volume and Issue: 13(2), P. 483 - 509

Published: Dec. 19, 2022

Computed tomography (CT), a diagnostic tool with clinical application, comprehensive coverage, and low cost, is used in hospitals worldwide. However, CT imaging fails to distinguish soft tissues from normal organs tumors because their mass attenuation coefficients are similar. Various contrast agents have been developed recent years improve the sensitivity of imaging. Here, we review progress nanomaterial-based applications image-guided therapy. The classified according components; gold (Au)-based, bismuth (Bi)-based, lanthanide (Ln)-based, transition metal (TM)-based nanomaterials discussed. therapy diseases, including photothermal (PPT), photodynamic (PDT), chemotherapy, radiotherapy (RT), gas therapy, sonodynamic (SDT), immunotherapy, starvation gene (GT), microwave thermal (MWTT), reviewed. Finally, perspectives on biomedical

Language: Английский

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Synergistic thermoradiotherapy based on PEGylated Cu 3 BiS 3 ternary semiconductor nanorods with strong absorption in the second near-infrared window

Biomaterials, Journal Year: 2016, Volume and Issue: 112, P. 164 - 175

Published: Oct. 16, 2016

Language: Английский

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Actively Targeted Deep Tissue Imaging and Photothermal‐Chemo Therapy of Breast Cancer by Antibody‐Functionalized Drug‐Loaded X‐Ray‐Responsive Bismuth Sulfide@Mesoporous Silica Core–Shell Nanoparticles

Advanced Functional Materials, Journal Year: 2017, Volume and Issue: 28(5)

Published: Dec. 11, 2017

Abstract A theranostic platform combining synergistic therapy and real‐time imaging attracts enormous attention but still faces great challenges, such as tedious modifications lack of efficient accumulation in tumor. Here, a novel type agent, bismuth sulfide@mesoporous silica (Bi 2 S 3 @mPS) core‐shell nanoparticles (NPs), for targeted image‐guided human epidermal growth factor receptor‐2 (HER‐2) positive breast cancer is developed. To generate NPs, polyvinylpyrrolidone decorated rod‐like Bi NPs are chemically encapsulated with mesoporous (mPS) layer loaded an anticancer drug, doxorubicin. The resultant then conjugated trastuzumab (Tam, monoclonal antibody targeting HER‐2 overexpressed cells) to form Tam‐Bi @mPS NPs. By vitro vivo studies, it demonstrated that the bear multiple desired features theranostics, including good biocompatibility drug loading ability well precise active tumor (with content being ≈16 times nontargeted group). They can simultaneously serve both excellent contrast enhancement probe (due presence strong X‐ray‐attenuating element) computed tomography deep tissue therapeutic agent destruct tumors prevent metastasis by photothermal‐chemo therapy.

Language: Английский

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Selenium Nanoparticles as an Efficient Nanomedicine for the Therapy of Huntington’s Disease

ACS Applied Materials & Interfaces, Journal Year: 2019, Volume and Issue: 11(38), P. 34725 - 34735

Published: Sept. 3, 2019

Huntington's disease (HD) is an incurable with progressive loss of neural function, which influenced by epigenetic, oxidative stress, metabolic, and nutritional factors. Targeting inhibition huntingtin protein aggregation a strategy for HD therapy, but the efficacy unsatisfactory. Studies found that selenium (Se) levels in brain are insufficient individuals, while improvement Se homeostasis may attenuate neuronal dysfunction. In this study, we applied nanoparticles (NPs) (Nano-Se) therapy regulating HD-related neurodegeneration cognitive decline based on transgenic models Caenorhabditis elegans (C. elegans). At low dosages, Nano-Se NPs significantly reduced death, relieved behavioral dysfunction, protected C. from damages stress conditions. The molecular mechanism further revealed attenuated inhibited proteins, downregulated expression histone deacetylase family members at mRNA levels. results suggested has great potential therapy. conclusion, about how protect conditions they repair functions will benefit This study also guide rational design or other compounds to improve future.

Language: Английский

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Renal‐Clearable PEGylated Porphyrin Nanoparticles for Image‐Guided Photodynamic Cancer Therapy

Advanced Functional Materials, Journal Year: 2017, Volume and Issue: 27(34)

Published: July 26, 2017

Nanomaterials with renal clearance from the body within a reasonable timescale have shown great promises in area of nanomedicine recently. However, integration theranostic and properties into single ultrasmall nanostructure remains challenge. Herein, meso ‐tetra(4‐carboxyphenyl)porphyrin (TCPP) structure is utilized as model, for first time using noninvasive dynamic positron emission tomography (PET) imaging to investigate balance tumor uptake behaviors polyethylene glycol (PEG)‐modified porphyrin nanoparticles (TCPP‐PEG) various molecular weights. This study finds that TCPP‐PEG larger weight show higher due enhanced permeability retention effect, while lower ones tend be better clearance. Based on PET fluorescence dual‐modal modalities, 10K seem an excellent choice retention. In vitro vivo photodynamic therapy confirms therapeutic efficacy. Therefore, this work presents simplified approach fabricate select biocompatible multifunctional TCPP‐PEG‐based agents behavior, which highlights clinical application potential probes imaging‐guided cancer therapy.

Language: Английский

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Renal-clearable ultrasmall covalent organic framework nanodots as photodynamic agents for effective cancer therapy

Biomaterials, Journal Year: 2019, Volume and Issue: 223, P. 119462 - 119462

Published: Aug. 30, 2019

Language: Английский

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Aggregation-induced emission (AIE) fluorophores as imaging tools to trace the biological fate of nano-based drug delivery systems

Advanced Drug Delivery Reviews, Journal Year: 2018, Volume and Issue: 143, P. 161 - 176

Published: Dec. 6, 2018

Language: Английский

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Ultrasmall CuCo₂S₄ Nanocrystals: All‐in‐One Theragnosis Nanoplatform with Magnetic Resonance/Near‐Infrared Imaging for Efficiently Photothermal Therapy of Tumors

Advanced Functional Materials, Journal Year: 2017, Volume and Issue: 27(10)

Published: Jan. 23, 2017

Copper‐based ternary bimetal chalcogenides have very promising potential as multifunctional theragnosis nanoplatform for photothermal treatment of tumors. However, the design and synthesis such an effective platform remains challenging. In this study, hydrophilic CuCo 2 S 4 nanocrystals (NCs) with a desirable size ≈10 nm are synthesized by simple one‐pot hydrothermal route. The as‐prepared ultrasmall NCs show: 1) intense near‐infrared absorption, which is attributed to 3d electronic transitions from valence band intermediate band, identified density functional theory calculations; 2) high performance conversion efficiency up 73.4%; 3) capability magnetic resonance (MR) imaging, result unpaired electrons cobalt. Finally, it demonstrated that “all‐in‐one” cancer therapy under irradiation 915 laser at safe power 0.5 W cm −2 , guided MR infrared thermal imaging. This work further promotes applications therapy.

Language: Английский

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