Recent Advances in Glucose‐Oxidase‐Based Nanocomposites for Tumor Therapy

Small, Journal Year: 2019, Volume and Issue: 15(51)

Published: Nov. 20, 2019

Abstract Glucose oxidase (GOx) can react with intracellular glucose and oxygen (O 2 ) to produce hydrogen peroxide (H O gluconic acid, which cut off the nutrition source of cancer cells consequently inhibit their proliferation. Therefore, GOx is recognised as an ideal endogenous oxido‐reductase for starvation therapy. This process further regulate tumor microenvironment by increasing hypoxia acidity. Thus, offers new possibilities elaborate design multifunctional nanocomposites However, natural expensive prepare purify exhibits immunogenicity, short in vivo half‐life, systemic toxicity. Furthermore, highly prone degrade after exposure biological conditions. These intrinsic shortcomings will undoubtedly limit its biomedical applications. Accordingly, some nanocarriers be used protect from surrounding environment, thus controlling or preserving activity. A variety including hollow mesoporous silica nanoparticles, metal–organic frameworks, organic polymers, magnetic nanoparticles are summarized construction GOx‐based multimodal synergistic In addition, current challenges promising developments this area highlighted.

Language: Английский

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Ultrasmall Magnetic CuFeSe₂ Ternary Nanocrystals for Multimodal Imaging Guided Photothermal Therapy of Cancer

ACS Nano, Journal Year: 2017, Volume and Issue: 11(6), P. 5633 - 5645

Published: May 19, 2017

Nanoscale ternary chalcogenides have attracted intense research interest due to their wealth of tunable properties and diverse applications in energy environmental biomedical fields. In this article, ultrasmall magnetic CuFeSe2 nanocrystals (<5.0 nm) were fabricated the presence thiol-functionalized poly(methacrylic acid) by an environmentally friendly aqueous method under ambient conditions. The small band gap existence intermediate bands lead a broad NIR absorbance range 500–1100 nm high photothermal conversion efficiency (82%) nanocrystals. resultant show superparamagnetism effective attenuation for X-rays. addition, they also exhibit excellent water solubility, colloidal stability, biocompatibility, multifunctional groups. These enable them be ideal nanotheranostic agent multimodal imaging [e.g., photoacoustic (PAI), resonance (MRI), computed tomography (CT) imaging] guided therapy cancer.

Language: Английский

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Copper Silicate Hollow Microspheres-Incorporated Scaffolds for Chemo-Photothermal Therapy of Melanoma and Tissue Healing

ACS Nano, Journal Year: 2018, Volume and Issue: 12(3), P. 2695 - 2707

Published: March 8, 2018

The treatment of melanoma requires complete removal tumor cells and simultaneous tissue regeneration tumor-initiated cutaneous defects. Herein, copper silicate hollow microspheres (CSO HMSs)-incorporated bioactive scaffolds were designed for chemo-photothermal therapy skin cancers tissue. CSO HMSs synthesized with interior external nanoneedle microstructure, showing excellent drug-loading capacity photothermal effects. With incorporation drug-loaded into the electrospun scaffolds, composite exhibited effects controlled NIR-triggered drug release, leading to distinctly synergistic cancer both in vitro vivo. Furthermore, such HMSs-incorporated could promote proliferation attachment normal accelerate healing tumor-bearing diabetic mice. Taken together, may be used eradication remaining after surgery healing, which offers an effective strategy

Language: Английский

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A bifunctional scaffold with CuFeSe2 nanocrystals for tumor therapy and bone reconstruction

Biomaterials, Journal Year: 2018, Volume and Issue: 160, P. 92 - 106

Published: Jan. 18, 2018

Language: Английский

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Review of Functionalized Nanomaterials for Photothermal Therapy of Cancers

ACS Applied Nano Materials, Journal Year: 2021, Volume and Issue: 4(11), P. 11353 - 11385

Published: Nov. 16, 2021

Photothermal therapy (PTT) is recognized as a promising approach for cancer theranostics via the nonradiative conversion of light into heat energy. PTT treatment able to reduce adverse side effects traditional chemotherapy. Some nanomaterials functionalized with unique physical and chemical properties have been integrated multiple imaging modalities therapeutic function applications. In past decade, various applications reviewed, but comprehensive survey all classes photothermal developed in recent years has not done. A discussion mechanisms using different their application combination useful providing insights material development disease future. this review, advancement excellence combined therapies field anticancer are discussed. The momentous property tailored advancing noninvasive also highlighted. Because great deal decades reviewed years, we only include latest results reported 5 comparison.

Language: Английский

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Magnetic Nanostructures: Rational Design and Fabrication Strategies toward Diverse Applications

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(6), P. 5411 - 5475

Published: Jan. 11, 2022

In recent years, the continuous development of magnetic nanostructures (MNSs) has tremendously promoted both fundamental scientific research and technological applications. Different from bulk magnet, systematic engineering on MNSs brought a great breakthrough in some emerging fields such as construction MNSs, magnetism exploration multidimensional their potential translational this review, we give detailed description synthetic strategies based features application discuss progress nanomedicines, advanced nanobiotechnology, catalysis, electromagnetic wave adsorption (EMWA), aiming to provide guidance for fabrication toward diverse

Language: Английский

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Mitochondria-targeting Cu ₃ VS ₄ nanostructure with high copper ionic mobility for photothermoelectric therapy

Science Advances, Journal Year: 2023, Volume and Issue: 9(44)

Published: Nov. 1, 2023

Thermoelectric therapy has emerged as a promising treatment strategy for oncology, but it is still limited by the low thermoelectric catalytic efficiency at human body temperature and inevitable tumor thermotolerance. We present photothermoelectric (PTET) based on triphenylphosphine-functionalized Cu

Language: Английский

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Enhanced Intracellular Ca²⁺ Nanogenerator for Tumor-Specific Synergistic Therapy via Disruption of Mitochondrial Ca²⁺ Homeostasis and Photothermal Therapy

ACS Nano, Journal Year: 2018, Volume and Issue: 12(7), P. 6806 - 6818

Published: July 2, 2018

Breast cancer therapy has always been a hard but urgent issue. Disruption of mitochondrial Ca2+ homeostasis reported as an effective antitumor strategy, while how to contribute overload effectively is critical To solve this issue, we designed and engineered dual enhanced nanogenerator (DECaNG), which can induce elevation intracellular through the following three ways: Calcium phosphate (CaP)-doped hollow mesoporous copper sulfide was basic generate directly persistently in lysosomes (low pH). Near-infrared light radiation (NIR, such 808 nm laser) accelerate generation from by disturbing crystal lattice via NIR-induced heat. Curcumin facilitate release endoplasmic reticulum cytoplasm inhibit expelling cytoplasmic membrane. The vitro study showed that DECaNG could produce large amount flow mitochondria, leading upregulation Caspase-3, cytochrome c, downregulation Bcl-2 ATP followed cell apoptosis. In addition, had outstanding photothermal effect. Interestingly, it found exerted stronger effect at lower pH due super small nanoparticles effect, thus enhancing therapy. vivo study, nanoplatform good tumor targeting treatment efficacy combination disruption metabolism CaNG sped up disintegration into smaller nanoparticles, reducing retention time vivo. Therefore, be promising drug delivery system for breast

Language: Английский

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Direct growth of CuCo₂S₄ nanosheets on carbon fiber textile with enhanced electrochemical pseudocapacitive properties and electrocatalytic properties towards glucose oxidation

Nanoscale, Journal Year: 2018, Volume and Issue: 10(29), P. 14304 - 14313

Published: Jan. 1, 2018

CuCo₂S₄ nanosheets on carbon fiber textile were synthesized by a one-step hydrothermal procedure for high-performance supercapacitors and non-enzymatic glucose sensors.

Language: Английский

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Multicomponent Transition Metal Dichalcogenide Nanosheets for Imaging‐Guided Photothermal and Chemodynamic Therapy

Advanced Science, Journal Year: 2020, Volume and Issue: 7(23)

Published: Sept. 30, 2020

Transition metal dichalcogenides (TMDs) have received considerable attention due to their strong absorption in the near-infrared (NIR) region, spin-orbit coupling, and excellent photothermal conversion efficiency (PCE). Herein, CoFeMn dichalcogenide nanosheets (CFMS NSs) are prepared via facile vulcanization of a lamellar CoFeMn-layered double hydroxide (LDH) precursor followed by polyvinyl pyrrolidone modification (to give CFMS-PVP NSs), found show photoacoustic (PA) imaging synergistic photothermal/chemodynamic therapy (PTT/CDT) performance. The as-prepared NSs inherit ultrathin morphology CoFeMn-LDH exhibit an outstanding performance with η 89.0%, highest PCE reported date for 2D TMD materials. Moreover, 50% maximum catalytic activity (Michaelis-Menten constant, Km) is attained 0.26 × 10-3 m H2O2 at 318 K, markedly lower than endogenous concentration inside tumor cells. In addition, complete apoptosis HepG2 cancer cells elimination vivo observed after treatment low dose, substantiating NSs' remarkable PTT/CDT efficacy. This work provides new approach synthesis high-quality multicomponent precise process control, potential mass production, performance, providing great promise theranostics.

Language: Английский

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