Bioactive Materials,
Journal Year:
2022,
Volume and Issue:
17, P. 29 - 48
Published: Jan. 19, 2022
Biotherapy
has
recently
become
a
hotspot
research
topic
with
encouraging
prospects
in
various
fields
due
to
wide
range
of
treatments
applications,
as
demonstrated
preclinical
and
clinical
studies.
However,
the
broad
applications
biotherapy
have
been
limited
by
critical
challenges,
including
lack
safe
efficient
delivery
systems
serious
side
effects.
Due
unique
potentials
biomaterials,
such
good
biocompatibility
bioactive
properties,
biomaterial-assisted
be
an
attractive
strategy.
The
biomaterial-based
possess
sufficient
packaging
capacity
versatile
functions,
enabling
sustained
localized
release
drugs
at
target
sites.
Furthermore,
biomaterials
can
provide
niche
specific
extracellular
conditions
for
proliferation,
differentiation,
attachment,
migration
stem
cells,
leading
tissue
regeneration.
In
this
review,
state-of-the-art
studies
on
biotherapy,
drug
delivery,
vaccine
development,
gene
therapy,
cell
summarized.
challenges
outlook
biotherapies
also
discussed.
Advanced Science,
Journal Year:
2022,
Volume and Issue:
9(22)
Published: June 2, 2022
Abstract
Tumor
immunotherapy
is
only
effective
in
a
fraction
of
patients
due
to
low
response
rate
and
severe
side
effects,
these
challenges
clinics
can
be
addressed
through
induction
immunogenic
cell
death
(ICD).
ICD
elicited
from
many
antitumor
therapies
release
danger
associated
molecular
patterns
(DAMPs)
tumor‐associated
antigens
facilitate
maturation
dendritic
cells
(DCs)
infiltration
cytotoxic
T
lymphocytes
(CTLs).
The
process
reverse
the
tumor
immunosuppressive
microenvironment
improve
sensitivity
immunotherapy.
Nanostructure‐based
drug
delivery
systems
(NDDSs)
are
explored
induce
by
incorporating
therapeutic
molecules
for
chemotherapy,
photosensitizers
(PSs)
photodynamic
therapy
(PDT),
photothermal
conversion
agents
(PTT),
radiosensitizers
radiotherapy
(RT).
These
NDDSs
loaded
at
right
dose
place
time,
resulting
greater
effectiveness
lower
toxicity.
Immunotherapeutic
also
combined
with
achieve
synergic
effect
multi‐modality
approach.
In
this
review,
harnessed
load
multiple
PDT,
PTT,
RT
combination
promote
reduce
effects
cancer
treatment.
ACS Nano,
Journal Year:
2020,
Volume and Issue:
14(5), P. 5686 - 5699
Published: April 22, 2020
Chronic
lung
infection
caused
by
bacterial
biofilms
is
an
extremely
serious
clinical
problem,
which
can
lead
to
the
failure
of
antibiotic
therapy.
Although
nanoparticles
have
shown
great
potential
in
treatment
biofilms,
efficient
penetration
and
retention
still
a
big
challenge.
To
address
this
issue,
we
herein
fabricate
size
charge
adaptive
azithromycin
(AZM)-conjugated
clustered
(denoted
as
AZM-DA
NPs)
therapeutic
agents
for
treating
biofilms.
The
NPs
are
prepared
electrostatic
complexation
between
AZM
conjugated
amino-ended
poly(amidoamine)
dendrimer
(PAMAM)
2,3-dimethyl
maleic
anhydride
(DA)
modified
poly(ethylene
glycol)-block-polylysine
(PEG-b-PLys).
It
noteworthy
that
disassemble
acidic
biofilm
microenvironment
(pH
6.0),
leading
release
secondary
AZM-conjugated
PAMAM
(PAMAM-AZM
NPs).
PAMAM-AZM
with
small
positive
beneficial
improved
inside
enhanced
permeabilization
membrane,
increased
internalization
AZM,
thus
exhibiting
excellent
antibiofilm
activities.
also
favorable
long-term
antibacterial
due
reduced
occurrence
drug
resistance.
In
vivo
performance
confirmed
burden
alleviated
inflammation
chronic
model.
This
research
not
only
develops
innovative
strategy
delivery
but
provides
effective
way
management
biofilm-associated
infections,
including
infection.
Journal of the American Chemical Society,
Journal Year:
2020,
Volume and Issue:
143(2), P. 538 - 559
Published: Dec. 28, 2020
The
past
few
decades
have
witnessed
an
evolution
of
nanomedicine
from
biologically
inert
entities
to
more
smart
systems,
aimed
at
advancing
in
vivo
functionality.
However,
we
should
recognize
that
most
systems
still
rely
on
reasonable
explanation-including
some
over-explanation-rather
than
definitive
evidence,
which
is
a
watershed
radically
determining
the
speed
and
extent
nanomedicine.
Probing
nano-bio
interactions
desirable
functionality
tissue,
cellular,
molecular
levels
frequently
overlooked.
Progress
toward
answering
these
questions
will
provide
instructive
insight
guiding
effective
chemo-physical
strategies.
Thus,
next
generation,
argue
much
effort
be
made
evidence
for
proof-of-mechanism,
lieu
creating
many
new
complicated
similar
proof-of-concept.
ACS Nano,
Journal Year:
2019,
Volume and Issue:
unknown
Published: Jan. 25, 2019
Owing
to
the
complex
and
still
not
fully
understood
physiological
environment,
development
of
traditional
nanosized
drug
delivery
systems
is
very
challenging
for
precision
cancer
therapy.
It
difficult
control
in
vivo
distribution
nanoparticles
after
intravenous
injection.
The
ideal
nanocarriers
should
only
have
stealth
surface
prolonged
circulation
time
but
also
possess
enhanced
cellular
internalization
tumor
sites.
Unfortunately,
uptake
seem
contradictory
each
other.
How
integrate
two
opposite
aspects
into
one
system
a
herculean
meaningful
task.
As
an
alternative
strategy,
chameleon-like
were
developed
achieve
long
while
maintaining
cell
uptake.
Such
can
"turn
off"
their
ability
during
circulation.
However,
be
readily
activated
upon
arriving
at
tissues.
In
this
way,
are
dialectical
unity
delivery.
review,
we
focus
on
engineering
obtain
simultaneous
surfaces
tumors.
current
strategies
ongoing
developments,
including
programmed
tumor-targeting
some
specific
zwitterionic
surfaces,
will
discussed
detail.
Nano Letters,
Journal Year:
2020,
Volume and Issue:
20(3), P. 2062 - 2071
Published: Feb. 25, 2020
Tumor
hypoxia
is
the
Achilles
heel
of
oxygen-dependent
photodynamic
therapy
(PDT),
and
tremendous
challenges
are
confronted
to
reverse
tumor
hypoxia.
In
this
work,
an
oxidative
phosphorylation
inhibitor
atovaquone
(ATO)
a
photosensitizer
chlorine
e6
(Ce6)-based
self-delivery
nanomedicine
(designated
as
ACSN)
were
prepared
via
π–π
stacking
hydrophobic
interaction
for
O2-economized
PDT
against
hypoxic
tumors.
Specifically,
carrier-free
ACSN
exhibited
extremely
high
drug
loading
rate
avoided
excipient-induced
systemic
toxicity.
Moreover,
not
only
dramatically
improved
solubility
stability
ATO
Ce6
but
also
enhanced
cellular
internalization
intratumoral
permeability.
Abundant
investigations
confirmed
that
effectively
suppressed
oxygen
consumption
by
inhibiting
mitochondrial
respiration.
Benefiting
from
synergistic
mechanism,
effect
was
observed
on
inhibition
growth.
This
system
oxygen-economized
might
be
potential
appealing
clinical
strategy
eradication.
Research,
Journal Year:
2021,
Volume and Issue:
2021
Published: Jan. 1, 2021
Although
photothermal
therapy
(PTT)
with
the
assistance
of
nanotechnology
has
been
considered
as
an
indispensable
strategy
in
biomedical
field,
it
still
encounters
some
severe
problems
that
need
to
be
solved.
Excessive
heat
can
induce
treated
cells
develop
thermal
resistance,
and
thus,
efficacy
PTT
may
dramatically
decreased.
In
meantime,
uncontrollable
diffusion
pose
a
threat
surrounding
healthy
tissues.
Recently,
low-temperature
(also
known
mild
or
mild-temperature
PTT)
demonstrated
its
remarkable
capacity
conquering
these
obstacles
shown
excellent
performance
bacterial
elimination,
wound
healing,
cancer
treatments.
Herein,
we
summarize
recently
proposed
strategies
for
achieving
based
on
nanomaterials
introduce
synthesis,
characteristics,
applications
nanoplatforms.
Additionally,
combination
other
therapeutic
modalities
defeating
cancers
synergistic
effect
combined
treatments
are
discussed.
Finally,
current
limitations
future
directions
inspiring
more
researchers
make
contributions
promoting
toward
successful
preclinical
clinical
disease
