Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: Nov. 24, 2022
Abstract
Sulfur
bonds,
especially
trisulfide
bond,
have
been
found
to
ameliorate
the
self-assembly
stability
of
homodimeric
prodrug
nanoassemblies
and
could
trigger
sensitive
reduction-responsive
release
active
drugs.
However,
antitumor
efficacy
with
single
reduction-responsivity
may
be
restricted
due
heterogeneous
tumor
redox
microenvironment.
Herein,
we
replace
middle
sulfur
atom
bond
an
oxidizing
tellurium
or
selenium
construct
dual-responsive
sulfur-tellurium-sulfur
sulfur-selenium-sulfur
hybrid
chalcogen
bonds.
The
exhibit
ultrahigh
dual-responsivity
both
oxidation
reduction
conditions,
which
effectively
address
Moreover,
promotes
prodrugs
by
providing
strong
intermolecular
forces
sufficient
steric
hindrance.
above
advantages
bridged
result
in
improved
docetaxel
satisfactory
safety.
exploration
bonds
drug
delivery
deepened
insight
into
development
prodrug-based
chemotherapy
heterogeneity,
thus
enriching
design
theory
nanomedicines.
Acta Pharmaceutica Sinica B,
Journal Year:
2021,
Volume and Issue:
12(1), P. 92 - 106
Published: Aug. 14, 2021
Nanoparticulate
drug
delivery
systems
(Nano-DDSs)
have
emerged
as
possible
solution
to
the
obstacles
of
anticancer
delivery.
However,
clinical
outcomes
and
translation
are
restricted
by
several
drawbacks,
such
low
loading,
premature
leakage
carrier-related
toxicity.
Recently,
pure
nano-assemblies
(PDNAs),
fabricated
self-assembly
or
co-assembly
molecules,
attracted
considerable
attention.
Their
facile
reproducible
preparation
technique
helps
remove
bottleneck
nanomedicines
including
quality
control,
scale-up
production
translation.
Acting
both
carriers
cargos,
carrier-free
PDNAs
an
ultra-high
even
100%
loading.
In
addition,
combination
therapies
based
on
could
possibly
address
most
intractable
problems
in
cancer
treatment,
tumor
metastasis
resistance.
present
review,
latest
development
for
treatment
is
overviewed.
First,
classified
according
composition
assembly
mechanisms
discussed.
Furthermore,
co-delivery
summarized,
with
special
focus
improvement
therapeutic
outcomes.
Finally,
future
prospects
challenges
efficient
therapy
spotlighted.
Small,
Journal Year:
2021,
Volume and Issue:
17(52)
Published: Aug. 3, 2021
The
antitumor
efficiency
and
clinical
translation
of
traditional
nanomedicines
is
mainly
restricted
by
low
drug
loading,
complex
preparation
technology,
potential
toxicity
caused
the
overused
carrier
materials.
In
recent
decades,
small-molecule
prodrug
nanoassemblies
(SMP-NAs),
which
are
formed
self-assembly
prodrugs
themselves,
have
been
widely
investigated
with
distinct
advantages
ultrahigh
drug-loading
negligible
excipients-trigged
adverse
reaction.
Benefited
from
simple
process,
SMP-NAs
used
for
chemotherapy,
phototherapy,
immunotherapy,
tumor
diagnosis.
addition,
combination
therapy
based
on
accurate
co-delivery
behavior
can
effectively
address
challenges
heterogeneity
multidrug
resistance.
Recent
trends
in
outlined,
corresponding
mechanisms
discussed
detail.
Besides,
smart
stimuli-responsive
summarized,
special
emphasis
structure-function
relationships.
Finally,
outlooks
cancer
highlighted.
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: Nov. 14, 2022
Epidermal
growth
factor
is
an
excellent
drug
for
promoting
wound
healing;
however,
its
conventional
administration
strategies
are
associated
with
pharmacodynamic
challenges,
such
as
low
transdermal
permeability,
reduction,
and
receptor
desensitization.
Here,
we
develop
a
microneedle-based
self-powered
transcutaneous
electrical
stimulation
system
(mn-STESS)
by
integrating
sliding
free-standing
triboelectric
nanogenerator
microneedle
patch
to
achieve
improved
epidermal
pharmacodynamics.
We
show
that
the
mn-STESS
facilitates
penetration
utilization
using
microneedles
pierce
stratum
corneum.
More
importantly,
find
it
converts
mechanical
energy
of
finger
into
electricity
mediates
through
microneedles.
demonstrate
applied
acts
"adjuvant"
suppresses
reduction
glutathione
upregulates
expression
in
keratinocyte
cells,
successfully
compensating
Collectively,
this
work
highlights
promise
adjuvants
improving
pharmacodynamics,
creating
combinatorial
therapeutic
traditional
drugs.
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(9), P. 13513 - 13553
Published: Sept. 1, 2022
Prodrugs
are
chemically
modified
drug
molecules
that
inactive
before
administration.
After
administration,
they
converted
in
situ
to
parent
drugs
and
induce
the
mechanism
of
action.
The
development
prodrugs
has
upgraded
conventional
treatments
terms
bioavailability,
targeting,
reduced
side
effects.
Especially
cancer
therapy,
application
achieved
substantial
therapeutic
From
serendipitous
discovery
early
stage
functional
design
with
pertinence
nowadays,
importance
is
self-evident.
At
present,
studying
stimuli-responsive
activation
mechanisms,
regulating
stimuli
intensity
vivo,
designing
nanoscale
prodrug
formulations
major
strategies
promote
prodrugs.
In
this
review,
we
provide
an
outlook
recent
cutting-edge
studies
on
nanosystems
from
these
three
aspects.
We
also
discuss
prospects
challenges
future
such
Advanced Science,
Journal Year:
2022,
Volume and Issue:
9(8)
Published: Jan. 22, 2022
Due
to
the
aggregation-caused
quenching
effect
and
near-infrared
I
poor
penetration
capabilities
of
common
fluorescent
molecules,
their
applications
in
visualized
imaging
photoactivated
treatment
are
limited.
Therefore,
new
II
(NIR-II)
molecule
(named
TST),
which
had
abilities
aggregation-induced
emission
(AIE)
photothermal
therapy
synthesized.
Moreover,
order
further
improve
its
yield
therapeutic
effect,
camptothecin
prodrug
(CPT-S-PEG)
novel
immune
checkpoint
inhibitor
AZD4635
used
co-assemble
with
TST
into
nanoparticles
for
drug
delivery.
On
account
strong
interaction
TST,
intramolecular
rotation
is
limited,
thereby
inhibiting
non-radiation
attenuation
promoting
fluorescence
generation
when
intact.
As
uptake
by
cancer
cells,
redox
sensitive
CPT-S-PEG
degraded
disintegrate.
The
released
enhances
non-radiative
expedites
conversion
because
removal
constraint
camptothecin.
Furthermore,
induces
immunogenic
cell
death
cells
releases
abundant
ATP
tumor
microenvironment
recruit
cells.
However,
superfluous
converted
immunosuppressive
adenosine
through
CD39-CD73-A2AR
pathway.
disintegration
just
blocks
this
pathway
timely,
achieving
favorable
synergistic
therapy,
chemotherapy,
immunotherapy.
Chemical Science,
Journal Year:
2022,
Volume and Issue:
13(15), P. 4239 - 4269
Published: Jan. 1, 2022
Small-molecule
prodrugs
have
become
the
main
toolbox
to
improve
unfavorable
physicochemical
properties
of
potential
therapeutic
compounds
in
contemporary
anti-cancer
drug
development.
Many
approved
small-molecule
prodrugs,
however,
still
face
key
challenges
their
pharmacokinetic
(PK)
and
pharmacodynamic
(PD)
properties,
thus
severely
restricting
further
clinical
applications.
Self-assembled
emerged
as
they
could
take
advantage
benefits
both
prodrug
design
nanomedicine,
so
maximize
loading,
reduce
premature
leakage,
PK/PD
parameters
targeting
ability.
Notably,
temporally
spatially
controlled
release
drugs
at
cancerous
sites
be
achieved
by
encoding
various
activable
linkers
that
are
sensitive
chemical
or
biological
stimuli
tumor
microenvironment
(TME).
In
this
review,
we
comprehensively
summarized
recent
progress
made
development
single/multiple-stimulus-responsive
self-assembled
for
mono-
combinatorial
therapy.
A
special
focus
was
placed
on
conjugation
strategies
(polymer-drug
conjugates,
drug-drug
Journal of Materials Chemistry B,
Journal Year:
2022,
Volume and Issue:
10(37), P. 7206 - 7221
Published: Jan. 1, 2022
Thioether-based
reactive
oxygen
species
(ROS)
responsive
polymers
and
polypeptides,
with
the
ability
to
self-assemble
in
aqueous
media
disassemble
or
being
transformed
presence
of
ROS,
are
ideal
candidates
for
target
biomedical
therapies.
