Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 451, P. 138621 - 138621
Published: Aug. 12, 2022
Language: Английский
Advanced Materials, Journal Year: 2021, Volume and Issue: 33(48)
Published: Sept. 27, 2021
Photodynamic therapy (PDT) has aroused great research interest in recent years owing to its high spatiotemporal selectivity, minimal invasiveness, and low systemic toxicity. However, due the hypoxic nature characteristic of many solid tumors, PDT is frequently limited therapeutic effect. Moreover, consumption O2 during may further aggravate tumor condition, which promotes proliferation, metastasis, invasion resulting poor prognosis treatment. Therefore, numerous efforts have been made increase content with goal enhancing efficacy. Herein, these strategies developed past decade are comprehensively reviewed alleviate hypoxia, including 1) delivering exogenous directly, 2) generating situ, 3) reducing cellular by inhibiting respiration, 4) regulating TME, (e.g., normalizing vasculature or disrupting extracellular matrix), 5) hypoxia-inducible factor 1 (HIF-1) signaling pathway relieve hypoxia. Additionally, -independent Type-I also discussed as an alternative strategy. By reviewing progress, it hoped that this review will provide innovative perspectives new nanomaterials designed combat hypoxia avoid associated limitation PDT.
Language: Английский
Citations
462
Acta Pharmaceutica Sinica B, Journal Year: 2021, Volume and Issue: 12(1), P. 92 - 106
Published: Aug. 14, 2021
Nanoparticulate drug delivery systems (Nano-DDSs) have emerged as possible solution to the obstacles of anticancer delivery. However, clinical outcomes and translation are restricted by several drawbacks, such low loading, premature leakage carrier-related toxicity. Recently, pure nano-assemblies (PDNAs), fabricated self-assembly or co-assembly molecules, attracted considerable attention. Their facile reproducible preparation technique helps remove bottleneck nanomedicines including quality control, scale-up production translation. Acting both carriers cargos, carrier-free PDNAs an ultra-high even 100% loading. In addition, combination therapies based on could possibly address most intractable problems in cancer treatment, tumor metastasis resistance. present review, latest development for treatment is overviewed. First, classified according composition assembly mechanisms discussed. Furthermore, co-delivery summarized, with special focus improvement therapeutic outcomes. Finally, future prospects challenges efficient therapy spotlighted.
Language: Английский
Citations
159
Theranostics, Journal Year: 2021, Volume and Issue: 11(7), P. 3278 - 3300
Published: Jan. 1, 2021
Photodynamic therapy (PDT), a non-invasive therapeutic modality, has received increasing attention owing to its high selectivity and limited side effects. Although significant clinical research progress been made in PDT, the breadth depth of application have not fully realized due limitations such as inadequate light penetration depth, non-targeting photosensitizers (PSs), tumor hypoxia. Consequently, numerous investigations put their emphasis on innovative strategies overcome aforementioned enhance effect PDT. Herein, up-to-date advances these methods for PDT are summarized by introducing design PS systems, working mechanisms examples. In addition, current challenges application, future perspectives further improvement also discussed.
Language: Английский
Citations
154
ACS Nano, Journal Year: 2020, Volume and Issue: 14(12), P. 17100 - 17113
Published: Nov. 25, 2020
Self-delivery of photosensitizer and immune modulator to tumor site is highly recommendable improve the photodynamic immunotherapy yet remains challenging. Herein, self-delivery photoimmune stimulators (designated as iPSs) are developed for sensitized immunotherapy. Carrier-free iPSs constructed by optimizing noncovalent interactions between pure drugs chlorine e6 (Ce6) NLG919, which avoid excipients-raised toxicity immunogenicity. Intravenously administrated prefer passively accumulate on tissues a robust therapy (PDT) with induction immunogenetic cell death (ICD) cascade activate cytotoxic T lymphocytes (CTLs) initiate antitumor response. Meanwhile, concomitant delivery NLG919 inhibits activation indoleamine 2,3-dioxygenase 1 (IDO-1) reverse immunosuppressive microenvironment. Ultimately, efficiently inhibit primary distant growth low system toxicity, would shed light development nanomedicine clinical transformation in precision therapy.
Language: Английский
Citations
143
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: Feb. 3, 2024
Abstract Chronic diabetic wounds are at lifelong risk of developing foot ulcers owing to severe hypoxia, excessive reactive oxygen species (ROS), a complex inflammatory microenvironment, and the potential for bacterial infection. Here we develop programmed treatment strategy employing live Haematococcus (HEA). By modulating light intensity, HEA can be perform variety functions, such as antibacterial activity, supply, ROS scavenging, immune regulation, suggesting its use in therapy. Under high intensity (658 nm, 0.5 W/cm 2 ), green (GHEA) with efficient photothermal conversion mediate wound surface disinfection. decreasing 0.1 photosynthetic system GHEA continuously produce oxygen, effectively resolving problems hypoxia promoting vascular regeneration. Continuous irradiation induces astaxanthin (AST) accumulation cells, resulting gradual transformation from red hue (RHEA). RHEA scavenges excess ROS, enhances expression intracellular antioxidant enzymes, directs polarization M2 macrophages by secreting AST vesicles via exosomes. The living hydrogel sterilize enhance cell proliferation migration promote neoangiogenesis, which could improve infected healing female mice.
Language: Английский
Citations
101
Progress in Materials Science, Journal Year: 2022, Volume and Issue: 125, P. 100919 - 100919
Published: Jan. 4, 2022
Language: Английский
Citations
94
Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 352, P. 793 - 812
Published: Nov. 11, 2022
Language: Английский
Citations
86
Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)
Published: Jan. 17, 2023
Abstract Nucleic acid drugs have the advantages of rich target selection, simple in design, good and enduring effect. They been demonstrated to irreplaceable superiority brain disease treatment, while vectors are a decisive factor therapeutic efficacy. Strict physiological barriers, such as degradation clearance circulation, blood-brain barrier, cellular uptake, endosome/lysosome release, obstruct delivery nucleic by vectors. against single inefficient treating diseases complex pathogenesis. Differences between individual patients lead severe uncertainties treatment with drugs. In this Review, we briefly summarize classification Next, discuss barriers during drug universal coping strategies introduce application methods these Subsequently, explore drug-based multidrug regimens for combination construction corresponding following, address feasibility patient stratification personalized therapy through diagnostic information from medical imaging manner introducing contrast agents into Finally, take perspective on future remaining challenges vector-based integrated diagnosis gene diseases.
Language: Английский
Citations
62
Asian Journal of Pharmaceutical Sciences, Journal Year: 2023, Volume and Issue: 18(1), P. 100775 - 100775
Published: Jan. 1, 2023
Photodynamic therapy (PDT) is applied as a robust therapeutic option for tumor, which exhibits some advantages of unique selectivity and irreversible damage to tumor cells. Among which, photosensitizer (PS), appropriate laser irradiation oxygen (O2) are three essential components PDT, but the hypoxic microenvironment (TME) restricts O2 supply in tissues. Even worse, metastasis drug resistance frequently happen under condition, further deteriorate antitumor effect PDT. To enhance PDT efficiency, critical attention has been received by relieving hypoxia, innovative strategies on this topic continue emerge. Traditionally, supplement strategy considered direct effective relieve TME, whereas it confronted with great challenges continuous supply. Recently, O2-independent provides brand new can avoid influence TME. In addition, synergize other strategies, such chemotherapy, immunotherapy, photothermal (PTT) starvation therapy, remedy inadequate hypoxia conditions. paper, we summarized latest progresses development improve efficacy against were classified into O2-dependent synergistic therapy. Furthermore, deficiencies various also discussed envisage prospects future study.
Language: Английский
Citations
56
Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(25)
Published: March 16, 2023
Abstract Sonodynamic therapy demonstrates tremendous potential in biomedicine due to its non‐invasiveness, deep tissue penetration, and spatiotemporal controllability. However, the lack of favorable nanosonosensitizers with prominent reactive oxygen species generation capability green chemical constituents remains a significant challenge for broad biomedical applications. Herein, homologous bismuth‐based nanosonosensitizer (Bi‐HJ) is designed fabricated by direct defect engineering combinational tumor therapy. Specifically, self‐derived Schottky heterojunction vacancies are concurrently constructed Bi‐HJ, which prominently promotes separation ultrasound‐triggered electron–hole pairs improves charge utilization efficiency. With porous structure, Bi‐HJ loaded metabolic regulation drug atovaquone block mitochondrial respiration oxygen‐economized sonodynamic suppression. The strong near‐infrared absorption imparted allows implementation photothermal Accordingly, rationally combines two therapeutic modalities function, as well computed tomography imaging ability, thus achieving effective theranostics vitro vivo. Therefore, this study provides new insight into fabrication without introduction other synergistically enhanced
Language: Английский
Citations
43