Small,
Journal Year:
2023,
Volume and Issue:
19(42)
Published: June 15, 2023
With
the
advantages
of
diverse
structures,
tunable
enzymatic
activity,
and
high
stability,
nanozymes
are
widely
used
in
medicine,
chemistry,
food,
environment,
other
fields.
As
an
alternative
to
traditional
antibiotics,
attract
more
attention
from
scientific
researchers
recent
years.
Developing
nanozymes-based
antibacterial
materials
opens
up
a
new
avenue
for
bacterial
disinfection
sterilization.
In
this
review,
classification
their
mechanisms
discussed.
The
surface
composition
critical
efficacy,
which
can
be
tailored
enhance
both
binding
activity.
On
one
hand,
modification
enables
targeting
bacteria
that
improves
performance
including
biochemical
recognition,
charge,
topography.
modulated
achieve
enhanced
single
nanozyme-mediated
synergistic
multiple
nanozymes-mediated
cascade
catalytic
applications.
addition,
current
challenges
future
prospects
tailoring
applications
This
review
provide
insights
into
design
treatments.
Small Methods,
Journal Year:
2022,
Volume and Issue:
6(11)
Published: Oct. 6, 2022
Abstract
Nanozymes
refer
to
nanomaterials
that
catalyze
enzyme
substrates
into
products
under
relevant
physiological
conditions
following
kinetics.
Compared
natural
enzymes,
nanozymes
possess
the
characteristics
of
higher
stability,
easier
preparation,
and
lower
cost.
Importantly,
magnetic,
fluorescent,
electrical
properties
nanomaterials,
making
them
promising
replacements
for
enzymes
in
industrial,
biological,
medical
fields.
On
account
rapid
development
recently,
their
application
potentials
regeneration
medicine
are
gradually
being
explored.
To
highlight
achievements
field,
this
review
summarizes
catalytic
mechanism
four
types
representative
nanozymes.
Then,
strategies
improve
biocompatibility
discussed.
covers
recent
advances
tissue
including
wound
healing,
nerve
defect
repair,
bone
regeneration,
cardiovascular
disease
treatment.
In
addition,
challenges
prospects
nanozyme
researches
summarized.
ACS Omega,
Journal Year:
2023,
Volume and Issue:
8(15), P. 13492 - 13508
Published: April 6, 2023
The
clinical
applications
of
nanotechnology
are
emerging
as
widely
popular,
particularly
a
potential
treatment
approach
for
infectious
diseases.
Diseases
associated
with
multiple
drug-resistant
organisms
(MDROs)
global
concern
morbidity
and
mortality.
prevalence
infections
caused
by
antibiotic-resistant
bacterial
strains
has
increased
the
urgency
researching
developing
novel
bactericidal
medicines
or
unorthodox
methods
capable
combating
antimicrobial
resistance.
Nanomaterial-based
treatments
promising
treating
severe
because
they
bypass
antibiotic
resistance
mechanisms.
approaches,
especially
those
that
do
not
rely
on
small-molecule
antimicrobials,
display
since
can
bacteria
systems.
Nanoparticles
(NPs)
small
enough
to
pass
through
cell
membranes
pathogenic
interfere
essential
molecular
pathways.
They
also
target
biofilms
eliminate
have
proven
difficult
treat.
In
this
review,
we
described
antibacterial
mechanisms
NPs
against
parameters
involved
in
targeting
established
biofilms.
Finally,
yet
importantly,
talked
about
various
ways
be
utilized,
including
delivery
methods,
intrinsic
mixture.
Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: Aug. 23, 2023
Safe
and
efficient
antibacterial
materials
are
urgently
needed
to
combat
drug-resistant
bacteria
biofilm-associated
infections.
The
rational
design
of
nanoparticles
for
flexible
elimination
biofilms
remains
challenging.
Herein,
we
propose
the
fabrication
Janus-structured
targeting
extracellular
polymeric
substance
achieve
dispersion
or
near-infrared
(NIR)
light-activated
photothermal
biofilms,
respectively.
Asymmetrical
dextran-bismuth
selenide
(Dex-BSe)
fabricated
exploit
synergistic
effects
both
components.
Interestingly,
Janus
Dex-BSe
realize
enhanced
dispersal
over
time.
Alternatively,
taking
advantage
preferential
accumulation
at
infection
sites,
self-propelled
active
motion
induced
by
unique
structure
enhances
killing
effect.
application
biofilm
removal
NIR-triggered
eradication
in
vivo
is
demonstrated
Staphylococcus
aureus-infected
mouse
excisional
wound
model
abscess
model,
developed
nanoplatform
holds
great
promise
diverse
scenarios.
Small,
Journal Year:
2023,
Volume and Issue:
19(42)
Published: June 15, 2023
With
the
advantages
of
diverse
structures,
tunable
enzymatic
activity,
and
high
stability,
nanozymes
are
widely
used
in
medicine,
chemistry,
food,
environment,
other
fields.
As
an
alternative
to
traditional
antibiotics,
attract
more
attention
from
scientific
researchers
recent
years.
Developing
nanozymes-based
antibacterial
materials
opens
up
a
new
avenue
for
bacterial
disinfection
sterilization.
In
this
review,
classification
their
mechanisms
discussed.
The
surface
composition
critical
efficacy,
which
can
be
tailored
enhance
both
binding
activity.
On
one
hand,
modification
enables
targeting
bacteria
that
improves
performance
including
biochemical
recognition,
charge,
topography.
modulated
achieve
enhanced
single
nanozyme-mediated
synergistic
multiple
nanozymes-mediated
cascade
catalytic
applications.
addition,
current
challenges
future
prospects
tailoring
applications
This
review
provide
insights
into
design
treatments.
