Discover Nano, Journal Year: 2023, Volume and Issue: 18(1)
Published: Dec. 19, 2023
The nanosystems for delivering drugs which have evolved with time, are being designed greater drug efficiency and lesser side-effects, also complemented by the advancement of numerous innovative materials. In comparison to organic nanoparticles, inorganic nanoparticles stable, a wide range physicochemical, mechanical, magnetic, optical characteristics, capability get modified using some ligands enrich their attraction towards molecules at target site, makes them appealing bio-imaging delivery applications. One strong benefits nanoparticles-drug conjugate is possibility affected cells locally, thus reducing side-effects like cytotoxicity, facilitating higher efficacy therapeutic drug. This review features direct indirect effects such gold, silver, graphene-based, hydroxyapatite, iron oxide, ZnO, CeO2 in developing effective carrier systems. article has remarked peculiarities these nanoparticle-based systems pulmonary, ocular, wound healing, antibacterial deliveries as well across Blood-Brain-Barrier (BBB) acting agents cancer theranostics. Additionally, sheds light on plausible modifications that can be carried out from researcher's perspective, could open new pathway.
Language: Английский
Citations
50
ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(3), P. 2529 - 2545
Published: Jan. 18, 2024
Antibiotic abuse has become a rising public health concern in recent years, leading to dangerous bacteria developing antibiotic resistance most medicines currently use. Traditional antimicrobial medications have been helpful the early stages of treating numerous forms serious bacterial infectious diseases; however, despite significant therapeutic benefit, there are number issues with follow-up treatment. Metal-based nanomaterials, which properties including difficulty establishing drug and advantages reduced cytotoxicity, considered promising substances. This review discusses important types metal-based nanoparticles (MNPs), such as copper, titanium, zinc oxide, etc., focus on applications gold- silver-based nanoparticles. Furthermore, advanced research progress MNPs agents stimuli-responsive metal nanoparticle strategies working under photothermal, magnetic, pH stimulation also summarized this article. In general, advancement technology, materials based will offer excellent prospects for improving applications.
Language: Английский
Citations
34
Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 162, P. 112286 - 112286
Published: March 11, 2024
Language: Английский
Citations
23
Heliyon, Journal Year: 2024, Volume and Issue: 10(3), P. e25607 - e25607
Published: Feb. 1, 2024
Ganoderma lucidum is a versatile mushroom. Polysaccharides and triterpenoids are the major bioactive compounds have been used as traditional medicinal mushrooms since ancient times. They currently nutraceuticals functional foods. G. extracts their an alternative to antioxidants antimicrobial agents. Secondary metabolites with many properties make it possible substitute that could be applied immunomodulatory, anticancer, antimicrobial, anti-oxidant, anti-inflammatory, anti-diabetic. The miraculous of secondary fascinate researchers for development production. Recent studies paid close attention different physical, genetic, biochemical, nutritional parameters potentiate production metabolites. This review effort collect biologically active constituents from reveal potential actions against diseases latest improvement in novel technique get maximum Studies going ahead determine efficacy numerous assess valuable achieved by favor antioxidant outcomes.
Language: Английский
Citations
20
ACS Omega, Journal Year: 2024, Volume and Issue: 9(31), P. 33303 - 33334
Published: July 25, 2024
The increasing occurrence of infectious diseases caused by antimicrobial resistance organisms urged the necessity to develop more potent, selective, and safe agents. unique magnetic tunable properties iron oxide nanoparticles (IONPs) make them a promising candidate for different theragnostic applications, including Though IONPs act as nonspecific agent, their activities are directly or indirectly linked with synthesis methods, synthesizing precursors, size, shapes, concentration, surface modifications. Alteration these parameters could accelerate decelerate production reactive oxygen species (ROS). An increase in ROS role disrupts bacterial cell walls, membranes, alters major biomolecules (e.g., lipids, proteins, nucleic acids), affects metabolic processes Krebs cycle, fatty acid synthesis, ATP glycolysis, mitophagy). In this review, we will investigate antibacterial activity bare surface-modified influence physiochemical on activity. Additionally, report potential mechanism IONPs' action driving
Language: Английский
Citations
16
Antibiotics, Journal Year: 2025, Volume and Issue: 14(2), P. 207 - 207
Published: Feb. 18, 2025
The rapid rise of antibiotic resistance has become a global health crisis, necessitating the development innovative strategies to combat multidrug-resistant (MDR) pathogens. Nanomaterials have emerged as promising tools in this fight, offering unique physicochemical properties that enhance efficacy, overcome mechanisms, and provide alternative therapeutic approaches. This review explores diverse nanomaterial-based used resistance, focusing on their mechanisms action practical applications. such metal nanoparticles, carbon-based nanomaterials, polymeric nanostructures exhibit antibacterial through various pathways, including generation reactive oxygen species (ROS), disruption bacterial membranes, enhancement delivery. Additionally, ability nanomaterials bypass traditional biofilm formation efflux pumps, been demonstrated numerous studies. also discusses synergistic effects observed when are combined with conventional antibiotics, leading increased susceptibility reduced required dosages. By highlighting recent advancements clinical applications nanomaterial-antibiotic combinations, paper provides comprehensive overview how reshaping future therapies. Future research directions challenges, toxicity scalability, addressed guide safer, more effective treatments.
Language: Английский
Citations
3
Molecules, Journal Year: 2023, Volume and Issue: 28(17), P. 6431 - 6431
Published: Sept. 4, 2023
The present study reports the biomimetic synthesis of silver nanoparticles (AgNPs) using a simple, cost effective and eco-friendly method. In this method, flavonoid extract Perilla frutescens (PFFE) was used as bioreduction agent for reduction metallic into nanosilver, called P. (PFFE-AgNPs). Ultraviolet–Visible (UV-Vis) spectrum showed characteristic absorption peak at 440 nm that confirmed PFFE-AgNPs. A Fourier transform infrared spectroscopic (FTIR) analysis PFFE-AgNPs revealed flavonoids are involved in capping processes. X-ray diffraction (XRD) selected area electron (SAED) patterns face-centered cubic (FCC) crystal structure transmission microscopic (TEM) indicated synthesized 20 to 70 size with spherical morphology without any aggregation. Dynamic light scattering (DLS) studies average hydrodynamic 44 nm. polydispersity index (PDI) 0.321 denotes monodispersed nature Further, highly negative surface charge or zeta potential value (−30 mV) indicates repulsion, non-aggregation, stability cytotoxic effects against cancer cell lines, including human colon carcinoma (COLO205) mouse melanoma (B16F10), IC50 concentrations 59.57 69.33 μg/mL, respectively. significant inhibition both Gram-positive (Listeria monocytogens Enterococcus faecalis) Gram-negative (Salmonella typhi Acinetobacter baumannii) bacteria pathogens. exhibited vitro antioxidant activity by quenching 1,1-diphenyl-2-picrylhydrazyl (DPPH) hydrogen peroxide (H2O2) free radicals values 72.81 92.48 µg/mL, study, we also explained plausible mechanisms biosynthesis, anticancer, antibacterial Overall, these findings suggest have multi-functional nanomaterial biomedical applications, particularly therapy infection control. However, it is important note further research needed determine safety efficacy vivo, well explore their other areas medicine.
Language: Английский
Citations
28
BioMed Research International, Journal Year: 2023, Volume and Issue: 2023(1)
Published: Jan. 1, 2023
The increasing public concern over the negative impacts of chemical fertilizers and pesticides on food security sustainability has led to exploring innovative methods that offer both environmental agricultural benefits. One such approach is using plant‐growth‐promoting bioinoculants involve bacteria, fungi, algae. These living microorganisms are applied soil, seeds, or plant surfaces can enhance development by nutrient availability defense against pathogens. However, application biofertilizers in field faced many challenges required conjunction with delivering approaches. Nanotechnology gained significant attention recent years due its numerous applications various fields, as medicine, drug development, catalysis, energy, materials. Nanoparticles small sizes large surface areas (1‐100 nm) have potential functions. In sustainable agriculture, nanochemicals shown promise agents for growth, fertilizers, pesticides. use nanomaterials being considered a solution control pests, including insects, weeds. industry, nanoparticles used antimicrobial packaging, silver particularly interesting. (Ag, Fe, Cu, Si, Al, Zn, ZnO, TiO 2 , CeO Al O 3 carbon nanotubes) been reported negatively affect growth. This review focuses effects beneficial bacteria their ability promote Implementing novel strategies biofertilizers, could be promising achieve production while reducing impacts.
Language: Английский
Citations
25
South African Journal of Botany, Journal Year: 2024, Volume and Issue: 167, P. 643 - 662
Published: March 11, 2024
Language: Английский
Citations
11
Food Chemistry, Journal Year: 2024, Volume and Issue: 450, P. 139324 - 139324
Published: April 10, 2024
Language: Английский
Citations
11