Curbing Exosome Communications via Introducing Artificial Membrane Receptors for Metastatic Pancreatic Cancer Therapy DOI
Miao Deng, Rong Guo, Yang Wang

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(39)

Published: July 25, 2023

Tumor-derived exosomes (TDEs) carry various biomolecular cargos and play crucial roles in metastasis. TDEs migrate to distal organs for intercellular communication induce the formation of pre-metastatic niches (PMNs) support tumor implantation proliferation. Precise interference bioprocess is expected be efficacious suppressing However, targeting both primary challenging. Here, based on metabolic glycoengineering bio-orthogonal click chemistry, a two-step delivery strategy designed overcome this. During first step, tetraacetylated N-azidoacetyl-d-mannosamine-loaded nanoparticle responds activity cells tumor, tagging with azide groups; dibenzyl-cyclootyne-modified nanoparticles then can, as second specifically react through reaction. This not only inhibits growth pancreatic cancer models but also curbs communicative role inducing liver PMNs metastasis by tracking downregulating exosomal macrophage migration inhibitory factor.

Language: Английский

Aggregation-Induced Emission (AIE), Life and Health DOI Creative Commons
Haoran Wang, Qiyao Li, Parvej Alam

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(15), P. 14347 - 14405

Published: July 24, 2023

Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents imaging techniques currently being used to assess health treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) shown great potential biological applications due its advantages terms of brightness, biocompatibility, photostability, positive correlation concentration. This review provides a comprehensive summary AIE luminogens applied structure dynamic physiological processes, disease diagnosis treatment, detection monitoring specific analytes, followed by representative works. Discussions on critical issues perspectives future directions are also included. aims stimulate the interest researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting development fields life health.

Language: Английский

Citations

189
Bioorthogonal Guided Activation of cGAS‐STING by AIE Photosensitizer Nanoparticles for Targeted Tumor Therapy and Imaging DOI

Minhui Cui,

Dongsheng Tang, Bin Wang

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(52)

Published: Sept. 5, 2023

Abstract Photodynamic therapy (PDT) and photothermal (PTT) leverage reactive oxygen species (ROS) control local hyperthermia by photosensitizer to perturb intracellular redox equilibrium, inducing DNA damage in both mitochondria nucleus, activating the cGAS‐STING pathway, ultimately eliciting antitumor immune responses. However, current photosensitizers are encumbered limitations such as suboptimal tumor targeting, aggregation‐caused quenching (ACQ), restricted excitation emission wavelengths. Here, this work designs novel nanoparticles based on aggregation‐induced (AIE) (BODTPE) for targeted near‐infrared II fluorescence imaging (NIR‐II FLI) with enhanced PDT/PTT effects. BODTPE is employed a monomer, dibenzocyclooctyne (DBCO)‐PEG 2k ‐amine serving an end‐capping polymer, synthesize BODTPE‐containing polymer (DBD). Further, through self‐assembly, DBD mPEG‐DSPE combined form (NP‐DBD). Notably, DBCO surface of NP‐DBD can react azide groups cancer cells pretreated Ac 4 ManNAz copper‐free click reaction. This innovative formulation led accumulation within sites, phenomenon convincingly demonstrated murine models subjected N ‐azidoacetylmannosamine‐tetraacylated (Ac ManNAz) pretreatment. Significantly, exhibits multifaceted effect encompassing PDT/PTT/NIR‐II FLI upon 808 nm laser irradiation, thereby better culminating compelling inhibition augmented robust modulation.

Language: Английский

Citations

67
Boosting Checkpoint Immunotherapy with Biomaterials DOI
Lujie Liu,

Yuanwei Pan,

Chenchen Zhao

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(4), P. 3225 - 3258

Published: Feb. 6, 2023

The immune checkpoint blockade (ICB) therapy has revolutionized the field of cancer treatment, while low response rates and systemic toxicity limit its clinical outcomes. With rapid advances in nanotechnology materials science, various types biomaterials have been developed to maximize therapeutic efficacy minimizing side effects by increasing tumor antigenicity, reversing immunosuppressive microenvironment, amplifying antitumor response, reducing extratumoral distribution inhibitors as well enhancing their retention within target sites. In this review, we reviewed current design strategies for different augment ICB effectively then discussed present representative biomaterial-assisted modulation targeted delivery boost therapy. Current challenges future development prospects expanding with were also summarized. We anticipate review will be helpful developing emerging promoting application

Language: Английский

Citations

58
Reactive oxygen species-responsive polymer drug delivery systems DOI Creative Commons
Jiaxue Liu,

Boyan Jia,

Zhibo Li

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11

Published: Feb. 2, 2023

Applying reactive polymer materials sensitive to biological stimuli has recently attracted extensive research interest. The special physiological effects of oxygen species (ROS) on tumors or inflammation and the application ROS-responsive polymers as drug-delivery systems in organisms have much attention. ROS is a vital disease signal molecule, unique accumulation pathological sites may enable deliver payload (such drugs, prodrugs, gene therapy fragments) targeted fashion. In this paper, progress their recent years were summarized analyzed. was reviewed from perspective nanoparticle drug delivery systems, multi-responsive hydrogels. It expected that our work will help understand future development trends field.

Language: Английский

Citations

45
New-generation advanced PROTACs as potential therapeutic agents in cancer therapy DOI Creative Commons
Chao Wang, Yujing Zhang,

Wujun Chen

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: May 21, 2024

Abstract Proteolysis-targeting chimeras (PROTACs) technology has garnered significant attention over the last 10 years, representing a burgeoning therapeutic approach with potential to address pathogenic proteins that have historically posed challenges for traditional small-molecule inhibitors. PROTACs exploit endogenous E3 ubiquitin ligases facilitate degradation of interest (POIs) through ubiquitin–proteasome system (UPS) in cyclic catalytic manner. Despite recent endeavors advance utilization clinical settings, majority fail progress beyond preclinical phase drug development. There are multiple factors impeding market entry PROTACs, insufficiently precise favorable POIs standing out as one most formidable obstacles. Recently, there been exploration new-generation advanced including PROTAC prodrugs, biomacromolecule-PROTAC conjugates, and nano-PROTACs, improve vivo efficacy PROTACs. These improved possess capability mitigate undesirable physicochemical characteristics inherent thereby enhancing their targetability reducing off-target side effects. The will mark pivotal turning point realm targeted protein degradation. In this comprehensive review, we meticulously summarized state-of-the-art advancements achieved by these cutting-edge elucidated underlying design principles, deliberated upon prevailing encountered, provided an insightful outlook on future prospects within field.

Language: Английский

Citations

29
Bioorthogonal “Click and Release” Reaction‐Triggered Aggregation of Gold Nanoparticles Combined with Released Lonidamine for Enhanced Cancer Photothermal Therapy DOI
Xiao Yan, Ke Li,

Tian‐Qiu Xie

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(13)

Published: Feb. 2, 2024

Abstract Cancer has been the most deadly disease, and 13 million cancer casualties are estimated to occur each year by 2030. Gold nanoparticles (AuNPs)‐based photothermal therapy (PTT) attracted great interest due its high spatiotemporal controllability noninvasiveness. Due trade‐off between particle size efficiency of AuNPs, rational design is needed realize aggregation AuNPs into larger particles with desirable NIR adsorption in tumor site. Exploiting bioorthogonal “Click Release” (BCR) reaction iminosydnone cycloalkyne, can be achieved attractively accompanied release chemotherapeutic drug purposed synergizing. We synthesize iminosydnone‐lonidamine (ImLND) as a prodrug choose dibenzocyclooctyne (DBCO) trigger BCR reaction. A PEGylated AuNPs‐based two‐component nanoplatform consisting prodrug‐loaded AuNPs‐ImLND tumor‐targeting peptide RGD‐conjugated AuNPs‐DBCO‐RGD designed. In therapeutic regimen, intravenously injected first for tumor‐specific enrichment retention. Once arrival later at site, highly photothermally active nanoaggregates formed via ImLND DBCO. The simultaneous lonidamine further enhanced performance sensitizing cells PTT.

Language: Английский

Citations

26
Lipid nanoparticle-based mRNA delivery systems for cancer immunotherapy DOI Creative Commons
Jieun Han, Jaesung Lim, Chi‐Pin James Wang

et al.

Nano Convergence, Journal Year: 2023, Volume and Issue: 10(1)

Published: Aug. 7, 2023

Abstract Cancer immunotherapy, which harnesses the power of immune system, has shown immense promise in fight against malignancies. Messenger RNA (mRNA) stands as a versatile instrument this context, with its capacity to encode tumor-associated antigens (TAAs), cell receptors, cytokines, and antibodies. Nevertheless, inherent structural instability mRNA requires development effective delivery systems. Lipid nanoparticles (LNPs) have emerged significant candidates for cancer providing both protection enhanced intracellular efficiency. In review, we offer comprehensive summary recent advancements LNP-based systems, focus on strategies optimizing design mRNA-encoded therapeutics treatment. Furthermore, delve into challenges encountered field contemplate future perspectives, aiming improve safety efficacy immunotherapies. Graphical

Language: Английский

Citations

39
Stimuli-activatable PROTACs for precise protein degradation and cancer therapy DOI
Jing Gao, Lei Yang,

Shumin Lei

et al.

Science Bulletin, Journal Year: 2023, Volume and Issue: 68(10), P. 1069 - 1085

Published: April 27, 2023

Language: Английский

Citations

34
Polymerization in living organisms DOI
Dan Wu, Jiaqi Lei,

Zhankui Zhang

et al.

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(9), P. 2911 - 2945

Published: Jan. 1, 2023

This review summarizes the progress of polymerization in living organisms. Based on different biological or cellular characteristics, versatile processes are designed and their corresponding therapeutic mechanisms discussed.

Language: Английский

Citations

30
Synthesizing biomaterials in living organisms DOI
Xiangyang Zhang, Junxia Wang, Ying Zhang

et al.

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(23), P. 8126 - 8164

Published: Jan. 1, 2023

Synthesizing biomaterials from building blocks in living organisms.

Language: Английский

Citations

28