Toward Nanotechnology-Enabled Approaches against the COVID-19 Pandemic

ACS Nano, Journal Year: 2020, Volume and Issue: 14(6), P. 6383 - 6406

Published: June 10, 2020

The COVID-19 outbreak has fueled a global demand for effective diagnosis and treatment as well mitigation of the spread infection, all through large-scale approaches such specific alternative antiviral methods classical disinfection protocols. Based on an abundance engineered materials identifiable by their useful physicochemical properties versatile chemical functionalization, nanotechnology offers number to cope with this emergency. Here, multidisciplinary Perspective encompassing diverse fields virology, biology, medicine, engineering, chemistry, science, computational we outline how nanotechnology-based strategies can support fight against COVID-19, infectious diseases in general, including future pandemics. Considering what know so far about life cycle virus, envision key steps where could counter disease. First, nanoparticles (NPs) offer protocols used healthcare settings, thanks intrinsic antipathogenic and/or ability inactivate viruses, bacteria, fungi, or yeasts either photothermally via photocatalysis-induced reactive oxygen species (ROS) generation. Nanotechnology tools SARS-CoV-2 patients also be explored. In case, nanomaterials deliver drugs pulmonary system inhibit interaction between angiotensin-converting enzyme 2 (ACE2) receptors viral S protein. Moreover, concept "nanoimmunity design" help us design immune modulation, stimulating suppressing response, which would find applications context vaccine development counteracting cytokine storm, respectively. addition disease prevention therapeutic potential, important roles diagnostics, potential simple, fast, cost-effective assays monitor presence related biomarkers. summary, is critical will vital when preparing

Language: Английский

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Fluorescent-based nanosensors for selective detection of a wide range of biological macromolecules: A comprehensive review

International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 206, P. 115 - 147

Published: Feb. 26, 2022

Thanks to their unique attributes, such as good sensitivity, selectivity, high surface-to-volume ratio, and versatile optical electronic properties, fluorescent-based bioprobes have been used create highly sensitive nanobiosensors detect various biological chemical agents. These sensors are superior other analytical instrumentation techniques like gas chromatography, high-performance liquid capillary electrophoresis for being biodegradable, eco-friendly, more economical, operational, cost-effective. Moreover, several reports also highlighted application in the early detection of biomarkers associated with drug-induced organ damage liver, kidney, or lungs. In present work, we comprehensively overviewed electrochemical that employ nanomaterials (nanoparticles/colloids quantum dots, carbon nanoscaled metal-organic frameworks, etc.) a variety macromolecules based on fluorescent emission spectra. addition, most important mechanisms methods sense amino acids, protein, peptides, enzymes, carbohydrates, neurotransmitters, nucleic vitamins, ions, metals, electrolytes, blood gases, drugs (i.e., anti-inflammatory agents antibiotics), toxins, alkaloids, antioxidants, cancer biomarkers, urinary metabolites urea, uric acid, creatinine), pathogenic microorganisms were outlined compared terms selectivity sensitivity. Altogether, small dimensions capability these nanosensors sensitive, label-free, real-time sensing chemical, biological, pharmaceutical could be array-based screening in-vitro in-vivo diagnostics. Although nanoprobes widely applied determining macromolecules, unfortunately, they many challenges limitations. Efforts must made minimize limitations utilizing an emphasis commercial developments. We believe current review can foster wider incorporation nanomedicine will particular interest researchers working fluorescence technology, material chemistry, coordination polymers, related research areas.

Language: Английский

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Molecularly Imprinted Polymer Nanoparticles: An Emerging Versatile Platform for Cancer Therapy

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 60(8), P. 3858 - 3869

Published: Aug. 13, 2020

Molecularly imprinted polymers (MIPs) are chemically synthesized affinity materials with tailor-made binding cavities complementary to the template molecules in shape, size, and functionality. Recently, engineering MIP-based nanomedicines improve cancer therapy has become a rapidly growing field future research direction. Because of unique properties functions MIPs, nanoparticles (nanoMIPs) not only alternatives current nanomaterials for therapy, but also hold potential fill gaps associated biological ligand-based nanomedicines, such as immunogenicity, stability, applicability, economic viability. Here, we survey recent advances design fabrication nanoMIPs highlight their distinct features. In addition, how use these features achieve desired performance, including extended circulation, active targeting, controlled drug release anti-tumor efficacy, is discussed summarized. We expect that this minireview will inspire more advanced studies therapy.

Language: Английский

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A Review on Silver Nanoparticles: Classification, Various Methods of Synthesis, and Their Potential Roles in Biomedical Applications and Water Treatment

Water, Journal Year: 2021, Volume and Issue: 13(16), P. 2216 - 2216

Published: Aug. 14, 2021

Recent developments in nanoscience have appreciably modified how diseases are prevented, diagnosed, and treated. Metal nanoparticles, specifically silver nanoparticles (AgNPs), widely used bioscience. From time to time, various synthetic methods for the synthesis of AgNPs reported, i.e., physical, chemical, photochemical ones. However, among these, most expensive not eco-friendly. The physicochemical parameters such as temperature, use a dispersing agent, surfactant, others greatly influence quality quantity synthesized NPs ultimately affect material’s properties. Scientists worldwide trying synthesize devising that easy apply, eco-friendly, economical. Among strategies is biogenic method, where plants source reducing capping agents. In this review, we intend debate different AgNP synthesis. Although, preparation electron irradiation, optical device ablation, chemical reduction, organic procedures, methods. processes preferably used, they environment-friendly review covers comprehensive discussion on biological activities AgNPs, antimicrobial, anticancer anti-inflammatory, anti-angiogenic potentials AgNPs. water treatment disinfection has also been discussed detail.

Language: Английский

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Advances in Biosensors and Diagnostic Technologies Using Nanostructures and Nanomaterials

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(44)

Published: July 28, 2021

Abstract Nanoscale materials have unique properties that make them especially useful for biomedical diagnostic applications. Recent developments in nanoengineering resulted increasing use of nanostructures biosensors. Various types 0D, 1D, 2D, and 3D been used to improve biosensor sensitivity, selectivity, limit detection, time result, among other metrics. These integrated into electrochemical, optical, biosensors this purpose. Here, the most recent advances nanostructured are described. This includes a discussion nanoparticles, nanorods, nanofibers, nanopillars, nanowires, nanosheets, indented nanopatterns (nanoholes nanoslits), nanogaps, nanochannels, nanopores, nanofunctionalized surfaces, complex hierarchical structures their advantages applications Clinical these nanobiosensors also highlighted along with future directions diagnostics.

Language: Английский

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Recent advances in cell membrane coated metal–organic frameworks (MOFs) for tumor therapy

Journal of Materials Chemistry B, Journal Year: 2021, Volume and Issue: 9(22), P. 4459 - 4474

Published: Jan. 1, 2021

In the presented perspective, synthetic method, characterization, and research progress in tumor therapy based on CMMs have been summarized. Also prospects challenges of utilizing for discussed.

Language: Английский

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A Critical Review of the Use of Surfactant-Coated Nanoparticles in Nanomedicine and Food Nanotechnology

International Journal of Nanomedicine, Journal Year: 2021, Volume and Issue: Volume 16, P. 3937 - 3999

Published: June 1, 2021

Abstract: Surfactants, whose existence has been recognized as early 2800 BC, have had a long history with the development of human civilization. With rapid nanotechnology in latter half 20th century, breakthroughs nanomedicine and food using nanoparticles remarkable, new applications developed. The technology surfactant-coated nanoparticles, which provides functions to for use fields nanotechnology, is attracting lot attention basic research industry. This review systematically describes these “surfactant-coated nanoparticles” through various sections order: 1) surfactants, 2) application 3) nanomedicine, 4) nanotechnology. Furthermore, current progress problems recent reports discussed. Keywords: drug delivery system, targeting, science, packaging, nonionic safety assessment

Language: Английский

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Plasmonic AuPt@CuS Heterostructure with Enhanced Synergistic Efficacy for Radiophotothermal Therapy

Journal of the American Chemical Society, Journal Year: 2021, Volume and Issue: 143(39), P. 16113 - 16127

Published: Sept. 28, 2021

Integrating multifunctional nanostructures capable of radiotherapy and photothermal ablation is an emerging alternative in killing cancer cells. In this work, we report a novel plasmonic heterostructure formed by decorating AuPt nanoparticles (NPs) onto the surfaces CuS nanosheets (AuPt@CuS NSs) as highly effective nanotheranostic toward dual-modal photoacoustic/computed tomography imaging enhanced synergistic radiophotothermal therapy. These heterostructures can confer higher conversion efficiency via local electromagnetic enhancement well greater radiation dose deposition form glutathione depletion reactive oxygen species generation. As result, depth tissue penetration improved, hypoxia tumor microenvironment alleviated. With efficacy radiotherapy, be eliminated without later recurrence. It believed that these will play vital role future oncotherapy with effects under guided potential dual-modality system.

Language: Английский

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Where Is Nano Today and Where Is It Headed? A Review of Nanomedicine and the Dilemma of Nanotoxicology

ACS Nano, Journal Year: 2022, Volume and Issue: 16(7), P. 9994 - 10041

Published: June 22, 2022

Worldwide nanotechnology development and application have fueled many scientific advances, but technophilic expectations technophobic demands must be counterbalanced in parallel. Some of the burning issues today are following: (1) Where is nano today? (2) How good communication investment networks between academia/research governments? (3) Is there any spotlight for nanotechnology? Nanomedicine a particular arm within healthcare landscape, focused on diagnosis, treatment, monitoring emerging (such as coronavirus disease 2019, COVID-19) contemporary (including diabetes, cardiovascular diseases, neurodegenerative disorders, cancer) diseases. However, it may only represent bright side coin. In fact, recent past, concept nanotoxicology has emerged to address dark shadows nanomedicine. The nanomedicine field requires more nanotoxicological studies identify undesirable effects guarantee safety. Here, we provide an overall perspective central pieces giant puzzle nanotechnology. First, impact education research highlighted, followed by market trends output tendencies. next section, dilemma addressed through interplay silico, vitro, vivo models with support omics microfluidic approaches. Lastly, reflection regulatory clinical trials provided. Finally, some conclusions future perspectives proposed clearer safer translation nanomedicines from bench bedside.

Language: Английский

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Engineering of BODIPY-based theranostics for cancer therapy

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 476, P. 214908 - 214908

Published: Nov. 7, 2022

Language: Английский

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