Cosmetics,
Journal Year:
2021,
Volume and Issue:
8(2), P. 39 - 39
Published: May 18, 2021
Limited
permeability
through
the
stratum
corneum
(SC)
is
a
major
obstacle
for
numerous
skin
care
products.
One
promising
approach
to
use
lipid
nanoparticles
as
they
not
only
facilitate
penetration
across
but
also
avoid
drawbacks
of
conventional
formulations.
This
review
focuses
on
solid
(SLNs),
nanostructured
nanocarriers
(NLCs),
and
nanoemulsions
(NEs)
developed
topical
transdermal
delivery
active
compounds.
A
special
emphasis
in
this
placed
composition,
preparation,
modifications,
structure
characterization,
mechanism
penetration,
recent
application
these
nanoparticles.
The
presented
data
demonstrate
potential
dermal
delivery.
Advanced Healthcare Materials,
Journal Year:
2021,
Volume and Issue:
11(5)
Published: June 24, 2021
Over
the
past
decades,
lipid-based
nanoparticle
drug
delivery
systems
(DDS)
have
caught
attention
of
researchers
worldwide,
encouraging
field
to
rapidly
develop
improved
ways
for
effective
delivery.
One
most
prominent
examples
is
liposomes,
which
are
spherical
shaped
artificial
vesicles
composed
lipid
bilayers
and
able
encapsulate
both
hydrophilic
hydrophobic
materials.
At
same
time,
biological
nanoparticles
naturally
secreted
by
cells,
called
extracellular
(EVs),
emerged
as
promising
more
complex
biocompatible
DDS.
In
this
review
paper,
differences
similarities
in
composition
evaluated,
critical
mediators
that
affect
their
pharmacokinetics
elucidate.
Different
strategies
been
assessed
tweak
liposomes
EVs
explored,
detailing
effects
on
circulation
targeting
capacity,
cytoplasmic
therapeutic
cargo.
Finally,
whether
a
hybrid
system,
consisting
combination
only
constituents
vesicles,
could
offer
best
worlds
discussed.
Through
these
topics,
novel
leads
further
research
provided
and,
importantly,
gain
insight
what
liposome
EV
can
learn
from
each
other.
Journal of Extracellular Vesicles,
Journal Year:
2022,
Volume and Issue:
11(2)
Published: Jan. 31, 2022
Abstract
Mounting
evidence
suggests
that
storage
has
an
impact
on
extracellular
vesicles
(EVs)
properties.
While
−80°C
is
a
widespread
approach,
some
authors
proposed
improved
strategies
with
conflicting
results.
Here,
we
designed
systematic
study
to
assess
the
of
and
freeze‐thaw
cycles
EVs.
We
tested
differences
among
eight
investigated
possible
fusion
phenomena
occurring
during
storage.
EVs
were
collected
from
human
plasma
murine
microglia
culture
by
size
exclusion
chromatography
ultracentrifugation,
respectively.
The
analysis
included:
concentration,
zeta
potential
(tunable
resistive
pulse
sensing),
contaminant
protein
assessment;
flow
cytometry
for
two
single
fluorescent‐tagged
populations
(GFP
mCherry),
mixed
before
preservation.
found
reduces
concentration
sample
purity
in
time‐dependent
manner.
Furthermore,
it
increases
particle
variability
modifies
potential,
shift
size‐charge
plots.
None
conditions
prevented
observed
effects.
Freeze‐thaw
lead
reduction
after
first
cycle
cycle‐dependent
increase
size.
With
cytometry,
storage,
significant
population
double‐positive
+
‐mCherry
).
This
observation
may
suggest
occurrence
Our
findings
show
samples
terms
loss,
leading
artefactual
particles.
Depending
downstream
analyses
experimental
settings,
should
probably
be
processed
fresh,
non‐archival,
majority
cases.
ACS Nano,
Journal Year:
2021,
Volume and Issue:
15(9), P. 13993 - 14021
Published: Sept. 10, 2021
Oligonucleotides
(ONs)
comprise
a
rapidly
growing
class
of
therapeutics.
In
recent
years,
the
list
FDA-approved
ON
therapies
has
expanded.
ONs
are
small
(15-30
bp)
nucleotide-based
therapeutics
which
capable
targeting
DNA
and
RNA
as
well
other
biomolecules.
can
be
subdivided
into
several
classes
based
on
their
chemical
modifications
mechanisms
target
interactions.
Historically,
largest
hindrance
to
widespread
usage
been
inability
effectively
internalize
cells
escape
from
endosomes
reach
molecular
targets
in
cytosol
or
nucleus.
While
cell
uptake
improved,
"endosomal
escape"
remains
significant
problem.
There
range
approaches
overcome
this,
this
review,
we
focus
three:
altering
structure
ONs,
formulating
synthetic,
lipid-based
nanoparticles
encapsulate
biologically
loading
extracellular
vesicles.
This
review
provides
background
design
mode
action
existing
ONs.
It
presents
most
common
classifications
fundamental
scientific
perspective
roadmap
cellular
pathways
by
trafficked.
Finally,
delves
each
above-mentioned
delivery,
highlighting
principles
behind
covering
advances.
Journal of Extracellular Vesicles,
Journal Year:
2022,
Volume and Issue:
11(10)
Published: Oct. 1, 2022
Extracellular
vesicles
(EVs)
are
lipid-membrane
enclosed
nanoparticles
that
play
significant
roles
in
health
and
disease.
EVs
abundant
body
fluids
carry
an
array
of
molecules
(proteins,
lipids,
nucleic
acids
glycans)
reflect
the
identity
activity
their
cell-of-origin.
While
advent
high
throughput
omics
technologies
has
allowed
in-depth
characterisation
EV
compositions,
how
these
molecular
species
spatially
distributed
within
structures
is
not
well
appreciated.
This
particularly
true
surface
where
a
plethora
reported
to
be
both
integral
peripherally
associated
membrane.
coronal
layer
or
'atmosphere'
surrounds
membrane
contributes
large,
highly
interactive
dynamic
area
responsible
for
facilitating
interactions
with
extracellular
environment.
The
harbours
parent
cells,
which
likely
valuable
property
context
diagnostic
liquid
biopsies.
In
this
review,
we
describe
current
understanding
mechanical,
electrostatic
properties
offer
biomarker
potential
contribute
interactome.
Journal of Extracellular Vesicles,
Journal Year:
2021,
Volume and Issue:
10(6)
Published: April 1, 2021
Abstract
Cellular,
inter‐organismal
and
cross
kingdom
communication
via
extracellular
vesicles
(EVs)
is
intensively
studied
in
basic
science
with
high
expectation
for
a
large
variety
of
bio‐technological
applications.
EVs
intrinsically
possess
many
attributes
drug
delivery
vehicle.
Beyond
the
implications
cell
biology,
academic
industrial
interests
have
increased
last
few
years.
Microalgae
constitute
sustainable
renewable
sources
bioactive
compounds
range
sectoral
applications,
including
formulation
health
supplements,
cosmetic
products
food
ingredients.
Here
we
describe
newly
discovered
subtype
derived
from
microalgae,
which
named
nanoalgosomes.
We
isolated
these
nano‐objects
cultures
microalgal
strains,
marine
photosynthetic
chlorophyte
Tetraselmis
chuii
,
using
differential
ultracentrifugation
or
tangential
flow
fractionation
focusing
on
nanosized
small
(sEVs).
explore
different
biochemical
physical
properties
show
that
nanoalgosomes
are
efficiently
taken
up
by
mammalian
lines,
confirming
potential
EVs.
This
first
detailed
description
such
membranous
nanovesicles
microalgae.
With
respect
to
other
organisms,
present
several
advantages
microalgae
natural
source,
could
easily
be
scalable
terms
nanoalgosome
production.
Theranostics,
Journal Year:
2022,
Volume and Issue:
12(11), P. 4879 - 4903
Published: Jan. 1, 2022
In
recent
decades,
extracellular
vesicles
(EVs),
as
bioactive
cell-secreted
nanoparticles
which
are
involved
in
various
physiological
and
pathological
processes
including
cell
proliferation,
immune
regulation,
angiogenesis
tissue
repair,
have
emerged
one
of
the
most
attractive
nanotherapeutics
for
regenerative
medicine.
Herein
we
provide
a
systematic
review
latest
progress
EVs
applications.
Firstly,
will
briefly
introduce
biogenesis,
function
isolation
technology
EVs.
Then,
underlying
therapeutic
mechanisms
native
unmodified
engineering
strategies
modified
entities
be
discussed.
Subsequently,
main
focus
placed
on
repair
regeneration
applications
organs
brain,
heart,
bone
cartilage,
liver
kidney,
well
skin.
More
importantly,
current
clinical
trials
medicine
also
highlighted.
Finally,
future
challenges
insightful
perspectives
currently
developed
EV-based
biomedicine
short,
opened
new
horizons
biologists,
chemists,
nanoscientists,
pharmacists,
clinicians,
making
possible
powerful
tools
therapies
Alexandria Engineering Journal,
Journal Year:
2023,
Volume and Issue:
70, P. 273 - 288
Published: March 7, 2023
In
this
work,
ZnO
nanoparticles
were
surface
modified
using
bis-(triethoxysilylpropyl)amine
(BTPA)
at
different
silane
concentrations
and
applied
as
photocatalyst
to
water
based
acrylic
film
degrade
benzene
in
gaseous
phase
under
UV/Vis
lights.
The
pure
characterized
FTIR,
TGA,
BET,
XRD,
XPS,
I-V,
photocurrent
response
photoluminescence
analysis.
results
showed
that
the
band
gap
of
decreased
from
3.21
2.98
eV
specific
area
increased
by
silanization
stoichiometric
concentration
(1X).
mechanical
properties
containing
nanocomposites
investigated.
addition
(at
3
wt%)
matrix
tensile
strength
197.9
123.3%
modulus
about
288.8
185.7%
compared
pristine
nanoparticle
films.
It
was
found
silanized
photocatalytic
degradation
20%
nano
nanocomposite.
removal
efficiency
97.28
85.39%
obtained
for
wt%
loading
content)
UV
visible
light
irradiations,
respectively.
