Materials,
Journal Year:
2023,
Volume and Issue:
16(18), P. 6143 - 6143
Published: Sept. 9, 2023
This
review
article
explores
the
multiple
applications
and
potential
of
metal-organic
frameworks
(MOFs)
in
biomedical
field.
With
their
highly
versatile
tunable
properties,
MOFs
present
many
possibilities,
including
drug
delivery,
biomolecule
recognition,
biosensors,
immunotherapy.
Their
crystal
structure
allows
precise
tuning,
with
ligand
typology
metal
geometry
playing
critical
roles.
MOFs’
ability
to
encapsulate
drugs
exhibit
pH-triggered
release
makes
them
ideal
candidates
for
precision
medicine,
cancer
treatment.
They
are
also
gene
carriers
genetic
disorders
have
been
used
biosensors
as
contrast
agents
magnetic
resonance
imaging.
Despite
complexities
encountered
modulating
properties
interactions
biological
systems,
further
research
on
is
imperative.
The
primary
focus
this
provide
a
comprehensive
examination
these
applications,
highlighting
current
achievements
encountered.
Such
efforts
will
uncover
untapped
creating
innovative
tools
emphasizing
need
invest
continued
exploration
promising
Chemical Society Reviews,
Journal Year:
2022,
Volume and Issue:
51(15), P. 6307 - 6416
Published: Jan. 1, 2022
This
review
highlights
the
recent
advances
of
metalated
covalent
organic
frameworks,
including
synthetic
strategies
and
applications,
discusses
current
challenges
future
directions.
Theranostics,
Journal Year:
2022,
Volume and Issue:
13(1), P. 295 - 323
Published: Dec. 19, 2022
Cancer
remains
a
severe
threat
to
human
health.
To
date,
although
various
therapeutic
methods,
including
radiotherapy
(RT),
chemotherapy,
chemodynamic
therapy
(CDT),
phototherapy,
starvation
therapy,
and
immunotherapy,
have
entered
new
stage
of
rapid
progress
in
cancer
theranostics,
their
limited
effect
significant
side
effects
need
be
considered
carefully.
With
the
development
nanotechnology,
marriage
nanomaterials
methods
provides
practical
possibility
improve
deficiencies
therapy.
Notably,
metal-organic
frameworks
(MOFs)
composed
ions/clusters
bridging
ligands
through
coordination
bonds
been
widely
applied
deal
with
drawbacks
different
such
as
effects,
low
stability,
poor
efficacy,
owing
controllable
morphologies,
tailorable
diameters,
diverse
compositions,
tunable
porosities,
high
specific
surface
areas,
facile
functionalization,
good
biocompatibility.
This
review
summarizes
recent
advanced
developments
achievements
multifunctional
MOF-based
nanoplatforms
for
single
RT,
CDT,
phototherapy
(photodynamic
photothermal
therapy),
combination
methods.
Moreover,
prospects
challenges
used
tumor
are
also
discussed.
Journal of Materials Chemistry B,
Journal Year:
2023,
Volume and Issue:
11(25), P. 5693 - 5714
Published: Jan. 1, 2023
Cancer
is
one
of
the
greatest
challenges
in
medical
science
today
as
it
poses
a
serious
threat
to
human
life.
In
view
this,
myriad
therapeutic
strategies
are
being
developed
for
treatment
cancer.
Despite
use
various
approaches,
they
still
insufficient
The
rapid
advancement
nanotechnology
currently
offers
exciting
possibilities
creation
novel
cancer
therapy
approaches.
Metal
organic
frameworks
(MOFs)
emerging
multifunctional
nanomaterials
that
find
prospective
applications
biomedical
field
owing
their
porosity,
large
specific
surface
area,
and
diversified
structures.
Amongst
varied
categories
MOFs,
Hf(IV)-based
MOFs
have
been
since
2012
finding
new
hence
this
class
gaining
immense
attention
amongst
material
biomaterial
chemists.
Most
importantly,
Hf(IV)-MOFs
comprising
high
Z-Hf
metal
content
may
be
capable
offering
options
therapy,
nonlinear
optics,
fluorescent
sensors,
photoresponsive
devices.
review,
progress
using
radiotherapy,
chemotherapy,
immunotherapy,
phototherapeutic
techniques,
or
combination
two
more
these
techniques
explored.
This
review
also
provides
insight
regarding
current
limitations
future
prospects
therapy.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(2), P. 1289 - 1324
Published: Jan. 2, 2024
A
significant
amount
of
progress
in
nanotechnology
has
been
made
due
to
the
development
engineered
nanoparticles.
The
use
metallic
nanoparticles
for
various
biomedical
applications
extensively
investigated.
Biomedical
research
is
highly
focused
on
them
because
their
inert
nature,
nanoscale
structure,
and
similar
size
many
biological
molecules.
intrinsic
characteristics
these
particles,
including
electronic,
optical,
physicochemical,
surface
plasmon
resonance,
that
can
be
altered
by
altering
size,
shape,
environment,
aspect
ratio,
ease
synthesis,
functionalization
properties,
have
led
numerous
applications.
Targeted
drug
delivery,
sensing,
photothermal
photodynamic
therapy,
imaging
are
some
these.
promising
clinical
results
NBTXR3,
a
high-Z
radiosensitizing
nanomaterial
derived
from
hafnium,
demonstrated
translational
potential
this
metal.
This
radiosensitization
approach
leverages
dependence
energy
attenuation
atomic
number
enhance
energy-matter
interactions
conducive
radiation
therapy.
High-Z
nanoparticle
localization
tumor
issue
differentially
increases
effect
ionizing
cancer
cells
versus
nearby
healthy
ones
mitigates
adverse
effects
reducing
overall
burden.
principle
enables
material
multifunctionality
as
contrast
agents
X-ray-based
imaging.
physiochemical
properties
hafnium
(Z
=
72)
particularly
advantageous
well-placed
K-edge
absorption
high
mass
coefficient
compared
elements
human
tissue
across
ranges
leads
attenuation.
Chemical
reactivity
allows
variety
composition,
functionalization.
Nanoparticles
such
oxide
exhibit
excellent
biocompatibility
inertness
prior
incidence
with
radiation.
Additionally,
optical
electronic
applicable
biosensing,
component
coatings,
semiconductors.
wide
interest
prompted
extensive
design
synthesis
facilitate
property
fine-tuning.
review
summarizes
synthetic
methods
hafnium-based
nanomaterials
imaging,
biosensing
mechanistic
focus.
discussion
future
perspective
section
highlights
elaborates
current
challenges.
By
focusing
factors
impacting
applicational
effectiveness
examining
limitations
aims
support
researchers
expedite
translation
nanomedicine.
Materials Horizons,
Journal Year:
2023,
Volume and Issue:
10(10), P. 4059 - 4082
Published: Jan. 1, 2023
Radiotherapy
is
a
key
pillar
of
solid
cancer
treatment.
Despite
high
level
conformal
dose
deposition,
radiotherapy
limited
due
to
co-irradiation
organs
at
risk
and
subsequent
normal
tissue
toxicities.
Nanotechnology
offers
an
attractive
opportunity
for
increasing
the
efficacy
safety
radiotherapy.
Leveraging
freedom
design
growing
synthetic
capabilities
nanomaterial-community,
variety
engineered
nanomaterials
have
been
designed
investigated
as
radiosensitizers
or
radioenhancers.
While
research
so
far
has
primarily
focused
on
gold
nanoparticles
other
atomic
number
materials
increase
absorption
cross
section
tumor
tissue,
recent
studies
are
challenging
traditional
concept
high-
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(17)
Published: Jan. 3, 2024
Abstract
Hypoxia,
as
a
distinctive
feature
of
tumors,
is
closely
related
to
tumor
recurrence,
metastasis,
and
treatment
resistance.
Metal–organic
framework
(MOF)
exhibits
an
increasing
number
advantages
in
cancer
therapy
owing
its
porous
structure,
large
specific
surface
area,
tunable
function.
The
MOF
nanocomposites
constructed
by
adjusting
components
can
effectively
overcome
hypoxia
significantly
enhance
the
anti‐tumor
effect.
In
this
review,
hypoxic
characteristics
tumors
current
strategies
for
constructing
that
are
summarized,
including
delivering
O
2
or
endogenously
generating
elevate
intra‐tumor
content;
inhibiting
HIF‐1
induced
products
alleviate
hypoxia;
reducing
cellular
aerobic
respiration
decrease
consumption,
exacerbating
improve
efficacy
hypoxia‐activated
pre‐drugs.
At
same
time,
applications
applied
different
therapeutic
methods
at
present
stage
described,
finally,
challenges
opportunities
further
development
discussed.
