Ionic copolymer-modified hexagonal carbon nitride tube as a high-performance catalyst for regioselective synthesis of hexahydroquinoline frameworks

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: 699, P. 134589 - 134589

Published: Oct. 1, 2024

Language: Английский

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A simple, safe, eco‐friendly, and unique synthesis of hexahydro‐quinolines employing Fe₃O₄‐MWCNT@MnO₂ as a reusable catalyst

Applied Organometallic Chemistry, Journal Year: 2024, Volume and Issue: 38(8)

Published: May 30, 2024

This work aims to explore the catalytic potential of manganese oxide (MnO 2 ) supported on (Fe 3 O 4 ‐MWCNT) nano‐composite, which is composed iron and multi‐walled carbon nanotubes. The nano‐composite was synthesized using a simple impregnation technique. catalyst material extensively characterized variety possible analytical methods, including X‐ray diffraction (XRD), Brunauer–Emmett–Teller (BET), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), transmission (TEM), energy dispersive spectroscopy (EDS). Then, utilizing multi‐component condensation protocol comprising substituted aldehydes, cyclohexadione, ethylacetoacetate, NH OAc, efficacy Fe ‐MWCNT@MnO assessed for synthesizing novel hexahydro‐quinoline analogues. found be effective because its huge specific surface area, stability, porosity, distinctive exposed surfaces. catalyst's exhibited an exceptionally active nature, as seen by notably high turnover frequency. Herein, we present reusable method that produces outstanding product yields (93%–97%) under mild reaction conditions, ethanol green solvent. Cost‐effectiveness, environmental safety, atom efficiency are achieved nano‐composite.

Language: Английский

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Reaction under Ball-Milling: Solvent- and Metal-Free One-Pot Diastereoselective Synthesis of Tetrahydroquinoline Derivatives as Potential Antibacterial and Anticancer Agents

Synlett, Journal Year: 2024, Volume and Issue: 35(20), P. 2487 - 2495

Published: Aug. 1, 2024

Abstract A mild and efficient one-pot, three-component ball-mill-assisted reaction of aldehydes, anilines, dihydrofuran (or dihydropyran cyclohexenone) has been described for the first time in presence catalytic amount aqueous perchloric acid (8 mol%) at room temperature under organic solvent- metal-free conditions. The reactions are fast (1 h), providing products with excellent yields high diastereoselectivity. This procedure endows a simple, efficient, cost-effective method diastereoselective synthesis furano- pyrano-tetrahydroquinolines phenanthridinone derivatives, which important biological compounds. diastereomers cis configuration were isolated as major products. H–H COSY, NOESY experiments X-ray crystallographic analysis selected compounds performed to confirm isomer. synthesized tetrahydroquinolines have evaluated vitro their antibacterial anticancer activities, it was found that both prepared showed significant properties.

Language: Английский

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Novel DABCO-Derived Ionic Liquids for Liquid Desiccant Air Conditioning

ACS Sustainable Chemistry & Engineering, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 19, 2024

Language: Английский

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Exploring the Synthetic and Antioxidant Potential of 1,2‐Disubstituted Benzimidazoles Using [Et₃NH][HSO₄] Ionic Liquid Catalyst

Chemistry & Biodiversity, Journal Year: 2023, Volume and Issue: 21(6)

Published: Sept. 18, 2023

An [Et

Language: Английский

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Sulphonic Acid Functionalized Ionic Liquids as an Efficient Catalyst for the Synthesis of Digeranyl Ethers and Geranyl Phenols

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(14)

Published: April 4, 2024

Abstract An alternate synthetic approach was developed for the synthesis of digeranyl ether and naturally occurring biologically active geranyl phenols using −SO 3 H functionalized ionic liquids within 0.5–1.5 h with better yields. This further explored different activated geraniol yielding via alkylation at ambient temperature as catalyst. The synthesized were characterized Py‐IR studies to establish Brønsted acidity Hammett characteristics all four liquids. Amongst these IL‐1 exhibited beneficial catalytic activity towards excellent Reusability indicated that recycled seven times without losing which corroborated pre‐ post‐characterization IL‐1. work also highlights route cannabinoid compounds their analogues.

Language: Английский

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Triton B Catalyzed Rapid and Mild Synthetic Protocol for both Henry Reaction of Isatin and Michael Reaction of Chalcone with Nitroalkane

Synlett, Journal Year: 2024, Volume and Issue: unknown

Published: April 23, 2024

Abstract A highly efficient and general synthetic protocol for both Henry Michael reactions was developed using metal-free catalyst Triton B (benzyltrimethylammonium hydroxide) isatins chalcones, respectively. This methodology is inexpensive, the reagents are easy to handle, approach offers wide functional group tolerance of chalcones. The base less toxic, recyclable, reusable. method reduces reaction times, minimizes reagent excess, avoids chromatography, aligned with sustainable chemistry principles, offering eco-friendly applications in diverse industries.

Language: Английский

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Carbamoyl 1,4-Dihydropyridine Derivatives: Synthesis and Impressive Antidiabetic Activity

Russian Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 60(5), P. 943 - 949

Published: May 1, 2024

Language: Английский

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Screening of synthesized perimidine compounds for the assessment of antimicrobial potential: in-vitro and in-silico molecular docking and molecular dynamics simulation studies

Discover Chemistry., Journal Year: 2024, Volume and Issue: 1(1)

Published: Oct. 9, 2024

Presently, antimicrobial resistance is a major and worldwide concern due to high rate of mutation in microorganisms, widespread use, lack efficacy drugs, low drug discovery rate. Considering the importance N-heterocycles as antibiotics, perimidine derivatives 3(a–v) have been synthesized via cyclocondensation reaction 1,8-diaminonaphthalene aryl aldehydes. Further, perimidines were screened potent agents in-vitro, in-silico, ADME MD simulation studies. All 22 studied against two-gram +ve (E. coli P. aeruginosa), −ve (S. aureus B. subtilis), two fungal (A. niger S. cerevisiae) strains using ciprofloxacin fluconazole reference drugs. The in-vitro study results showed that compounds 3e, 3h, 3l, 3m most 3(a–d), 3(g–i), 3s active subtilis compared standard. Furthermore, molecular docking studies performed Dihydrofolate reductase (PDB Id: 3SRW) from aureus, DNA gyrase 4DUH) E. coli, ERG11 gene 4LXJ). Compounds 3f, 3f/3m, 3o found bind efficiently with highest binding energy − 10.6, 9.6, 11.3kcal/mol depicting potential inhibitor 3SRW, 4DUH, 4LXJ receptor protein, respectively. drug-likeness properties SwissADME program. To further validate these findings, dynamics simulations conducted evaluate their stability. From studies, it was observed all shortlisted displayed stable within site selected proteins.

Language: Английский

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Aqueous-mediated DABCO and DABCO-ionic liquid catalysed synthesis of 3-acetylcoumarins: exploration by kinetic, electrochemical and spectroscopic studies

RSC Sustainability, Journal Year: 2024, Volume and Issue: 2(12), P. 4008 - 4027

Published: Jan. 1, 2024

Efficient and eco-friendly synthesis of 3-acetylcoumarins using DABCO DABCO-ionic liquid catalyst.

Language: Английский

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