Synlett,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 23, 2024
Abstract
A
highly
efficient
and
general
synthetic
protocol
for
both
Henry
Michael
reactions
was
developed
using
metal-free
catalyst
Triton
B
(benzyltrimethylammonium
hydroxide)
isatins
chalcones,
respectively.
This
methodology
is
inexpensive,
the
reagents
are
easy
to
handle,
approach
offers
wide
functional
group
tolerance
of
chalcones.
The
base
less
toxic,
recyclable,
reusable.
method
reduces
reaction
times,
minimizes
reagent
excess,
avoids
chromatography,
aligned
with
sustainable
chemistry
principles,
offering
eco-friendly
applications
in
diverse
industries.
ChemistrySelect,
Journal Year:
2025,
Volume and Issue:
10(20)
Published: May 1, 2025
Abstract
[(DABCO)
2
C
3
H
5
OH].CoCl
4
,
a
novel
Lewis
acidic
ionic
liquid,
was
prepared
and
properly
characterized
by
variety
of
techniques,
including
Fourier
transform
infrared
(FT‐IR)
spectroscopy,
thermogravimetric
analysis
(TGA),
X‐ray
diffraction
(XRD)
pattern,
energy
dispersive
X‐ray(EDX)
analysis,
field
emission
scanning
electron
microscopy
(FESEM).
Subsequently,
the
promoting
ability
this
reagent
investigated
in
one‐pot
synthesis
2,3‐dihydroquinazolin‐4(1
)‐ones
through
green
sustainable
procedure.
Ease
preparation
reusability
short
reaction
times,
excellent
yields
obtained
compounds,
solvent‐free
nature
conditions
are
among
prominent
features
presented
protocol.
Applied Organometallic Chemistry,
Journal Year:
2024,
Volume and Issue:
38(8)
Published: May 30, 2024
This
work
aims
to
explore
the
catalytic
potential
of
manganese
oxide
(MnO
2
)
supported
on
(Fe
3
O
4
‐MWCNT)
nano‐composite,
which
is
composed
iron
and
multi‐walled
carbon
nanotubes.
The
nano‐composite
was
synthesized
using
a
simple
impregnation
technique.
catalyst
material
extensively
characterized
variety
possible
analytical
methods,
including
X‐ray
diffraction
(XRD),
Brunauer–Emmett–Teller
(BET),
thermogravimetric
analysis
(TGA),
scanning
electron
microscopy
(SEM),
transmission
(TEM),
energy
dispersive
spectroscopy
(EDS).
Then,
utilizing
multi‐component
condensation
protocol
comprising
substituted
aldehydes,
cyclohexadione,
ethylacetoacetate,
NH
OAc,
efficacy
Fe
‐MWCNT@MnO
assessed
for
synthesizing
novel
hexahydro‐quinoline
analogues.
found
be
effective
because
its
huge
specific
surface
area,
stability,
porosity,
distinctive
exposed
surfaces.
catalyst's
exhibited
an
exceptionally
active
nature,
as
seen
by
notably
high
turnover
frequency.
Herein,
we
present
reusable
method
that
produces
outstanding
product
yields
(93%–97%)
under
mild
reaction
conditions,
ethanol
green
solvent.
Cost‐effectiveness,
environmental
safety,
atom
efficiency
are
achieved
nano‐composite.
Synlett,
Journal Year:
2024,
Volume and Issue:
35(20), P. 2487 - 2495
Published: Aug. 1, 2024
Abstract
A
mild
and
efficient
one-pot,
three-component
ball-mill-assisted
reaction
of
aldehydes,
anilines,
dihydrofuran
(or
dihydropyran
cyclohexenone)
has
been
described
for
the
first
time
in
presence
catalytic
amount
aqueous
perchloric
acid
(8
mol%)
at
room
temperature
under
organic
solvent-
metal-free
conditions.
The
reactions
are
fast
(1
h),
providing
products
with
excellent
yields
high
diastereoselectivity.
This
procedure
endows
a
simple,
efficient,
cost-effective
method
diastereoselective
synthesis
furano-
pyrano-tetrahydroquinolines
phenanthridinone
derivatives,
which
important
biological
compounds.
diastereomers
cis
configuration
were
isolated
as
major
products.
H–H
COSY,
NOESY
experiments
X-ray
crystallographic
analysis
selected
compounds
performed
to
confirm
isomer.
synthesized
tetrahydroquinolines
have
evaluated
vitro
their
antibacterial
anticancer
activities,
it
was
found
that
both
prepared
showed
significant
properties.
ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(14)
Published: April 4, 2024
Abstract
An
alternate
synthetic
approach
was
developed
for
the
synthesis
of
digeranyl
ether
and
naturally
occurring
biologically
active
geranyl
phenols
using
−SO
3
H
functionalized
ionic
liquids
within
0.5–1.5
h
with
better
yields.
This
further
explored
different
activated
geraniol
yielding
via
alkylation
at
ambient
temperature
as
catalyst.
The
synthesized
were
characterized
Py‐IR
studies
to
establish
Brønsted
acidity
Hammett
characteristics
all
four
liquids.
Amongst
these
IL‐1
exhibited
beneficial
catalytic
activity
towards
excellent
Reusability
indicated
that
recycled
seven
times
without
losing
which
corroborated
pre‐
post‐characterization
IL‐1.
work
also
highlights
route
cannabinoid
compounds
their
analogues.
Discover Chemistry.,
Journal Year:
2024,
Volume and Issue:
1(1)
Published: Oct. 9, 2024
Presently,
antimicrobial
resistance
is
a
major
and
worldwide
concern
due
to
high
rate
of
mutation
in
microorganisms,
widespread
use,
lack
efficacy
drugs,
low
drug
discovery
rate.
Considering
the
importance
N-heterocycles
as
antibiotics,
perimidine
derivatives
3(a–v)
have
been
synthesized
via
cyclocondensation
reaction
1,8-diaminonaphthalene
aryl
aldehydes.
Further,
perimidines
were
screened
potent
agents
in-vitro,
in-silico,
ADME
MD
simulation
studies.
All
22
studied
against
two-gram
+ve
(E.
coli
P.
aeruginosa),
−ve
(S.
aureus
B.
subtilis),
two
fungal
(A.
niger
S.
cerevisiae)
strains
using
ciprofloxacin
fluconazole
reference
drugs.
The
in-vitro
study
results
showed
that
compounds
3e,
3h,
3l,
3m
most
3(a–d),
3(g–i),
3s
active
subtilis
compared
standard.
Furthermore,
molecular
docking
studies
performed
Dihydrofolate
reductase
(PDB
Id:
3SRW)
from
aureus,
DNA
gyrase
4DUH)
E.
coli,
ERG11
gene
4LXJ).
Compounds
3f,
3f/3m,
3o
found
bind
efficiently
with
highest
binding
energy
−
10.6,
9.6,
11.3kcal/mol
depicting
potential
inhibitor
3SRW,
4DUH,
4LXJ
receptor
protein,
respectively.
drug-likeness
properties
SwissADME
program.
To
further
validate
these
findings,
dynamics
simulations
conducted
evaluate
their
stability.
From
studies,
it
was
observed
all
shortlisted
displayed
stable
within
site
selected
proteins.
