Antimicrobial nanoparticles: current landscape and future challenges

RSC Pharmaceutics, Journal Year: 2024, Volume and Issue: 1(3), P. 388 - 402

Published: Jan. 1, 2024

Antimicrobial resistance poses a serious threat to global health, necessitating the exploration of innovative solutions.

Language: Английский

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Liposomal drug delivery strategies to eradicate bacterial biofilms: Challenges, recent advances, and future perspectives

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 655, P. 124046 - 124046

Published: March 29, 2024

Typical antibiotic treatments are often ineffectual against biofilm-related infections since bacteria residing within biofilms have developed various mechanisms to resist antibiotics. To overcome these limitations, antimicrobial-loaded liposomal nanoparticles a promising anti-biofilm strategy as they demonstrated improved delivery and eradication of in biofilms. Antibiotic-loaded revealed remarkably higher antibacterial activities than free drugs experimental settings. Moreover, can be used efficaciously for the combinational antibiotics other antimicrobial compounds/peptide which facilitate, instance, significant breakdown biofilm matrix, increased bacterial elimination from depletion metabolic activity pathogens. Drug-loaded liposomes mitigated recurrent considered tool address challenges associated resistance. Furthermore, it has been that surface charge polyethylene glycol modification notable impact on their activity. Future investigations should tackle persistent hurdles with development safe effective clinical application investigate novel treatments, including CRISPR-Cas gene editing, natural compounds, phages, nano-mediated approaches. Herein, we emphasize significance inhibition biofilms, challenges, recent advances, future perspectives.

Language: Английский

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A Critical Review on Sustainable Formulation of Anti-quorum Sensing Compounds Using Nanotechnology Principles Against Candida albicans

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 2, 2025

Language: Английский

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Green Nanotechnology: Naturally Sourced Nanoparticles as Antibiofilm and Antivirulence Agents Against Infectious Diseases

International Journal of Microbiology, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

The escalating threat of infectious diseases, exacerbated by antimicrobial resistance (AMR) and biofilm formation, necessitates innovative therapeutic strategies. This review presents a comprehensive exploration the potential nanoparticles synthesized from natural sources, including plant extracts, microbial products, marine compounds, as agents. These naturally derived demonstrated significant antibiofilm antivirulence effects, with specific examples revealing their capacity to reduce mass up 78% inhibit bacterial quorum sensing 65%. integration bioactive such polyphenols chitosan, facilitates nanoparticle stability enhances efficacy, while green synthesis protocols environmental risks. Notably, identifies silver using tea achieving 85% inhibition polymicrobial growth in vitro. Despite these promising results, challenges standardization scalability persist. study underscores transformative leveraging sourced sustainable alternatives conventional antimicrobials, offering quantitative insights for future application combating mono- infections.

Language: Английский

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Extracellular synthesis of silver nanoparticle using yeast extracts: antibacterial and seed priming applications

Applied Microbiology and Biotechnology, Journal Year: 2024, Volume and Issue: 108(1)

Published: Jan. 19, 2024

Language: Английский

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Investigating Biofilms: Advanced Methods for Comprehending Microbial Behavior and Antibiotic Resistance

Frontiers in Bioscience-Landmark, Journal Year: 2024, Volume and Issue: 29(4), P. 133 - 133

Published: March 29, 2024

Biofilms, which consist of microorganisms enclosed in an extracellular polymeric material (EPS), hold immense importance the fields environmental research, industry, and medicine. They play a significant role ecosystem dynamics stability, but they also pose issues such as biofouling, corrosion, pollution. Biofilms medical environments are linked to persistent infections elevated healthcare expenses. The EPS matrix plays crucial maintaining structural integrity antibiotic resistance these structures. research primarily investigates facilitating horizontal gene transfer among biofilm communities, with particular emphasis on its impact this process. process is recognized pivotal mechanism emergence resistance, underscoring function biofilms. analysis highlights financial constraints caused by biofilms several industries. Biofilm-associated sector result escalated treatment expenses extended hospitalization periods. In industrial context, have increasing maintenance product contamination, emphasizing need for efficient management solutions. This review presents most recent progress utilization sophisticated imaging tools molecular methodologies. addition conventional techniques, explores tools, DNA RNA sequencing, conjunction proteomics. These approaches essential assessing genetic metabolic mechanisms that regulate development resistance. underscores significance employing interdisciplinary methodology study By incorporating range approaches, analysis, comprehensive understanding may be achieved. approach opens up possibilities developing novel solutions address negative impacts health, environment.

Language: Английский

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Photo-catalytic and biological applications of phyto-functionalized zinc oxide nanoparticles synthesized using a polar extract of Equisetum diffusum D

RSC Advances, Journal Year: 2024, Volume and Issue: 14(31), P. 22344 - 22358

Published: Jan. 1, 2024

In this study, zinc oxide nanoparticles (ZnO NPs) were fabricated using

Language: Английский

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Bioinspired green synthesis of ZnO nanoparticles by marine-derived Streptomyces plicatus and its multifaceted biomedicinal properties

Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: 193, P. 106758 - 106758

Published: June 19, 2024

Language: Английский

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Anti-Biofouling Efficacy of Chitosan Nanocomposites in Shrimp Culture Ponds: A Green Nanotechnology Solution

Journal of environmental chemical engineering, Journal Year: 2025, Volume and Issue: unknown, P. 115577 - 115577

Published: Jan. 1, 2025

Language: Английский

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Advancing Nanotechnology: Targeting Biofilm-Forming Bacteria with Antimicrobial Peptides

BME Frontiers, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Nanotechnology offers innovative solutions for addressing the challenges posed by biofilm-forming bacteria, which are highly resistant to conventional antimicrobial therapies. This review explores integration of pharmaceutical nanotechnology with peptides (AMPs) enhance treatment biofilm-related infections. The use various nanoparticle systems-including inorganic/metallic, polymeric, lipid-based, and dendrimer nanostructures-provides promising avenues improving drug delivery, targeting, biofilm disruption. These nanocarriers facilitate penetration biofilms, down-regulate biofilm-associated genes, such as ALS1, ALS3, EFG1, HWP1, inhibit bacterial defense mechanisms through membrane disruption, reactive oxygen species generation, intracellular targeting. Furthermore, formulations NZ2114-NPs demonstrate enhanced efficacy reducing counts several orders magnitude. highlights potential combining AMPs create novel, targeted therapeutic approaches combatting infections overcoming limitations traditional treatments.

Language: Английский

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