Clinical & Translational Oncology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 20, 2024
Language: Английский
Life Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 123472 - 123472
Published: Feb. 1, 2025
Language: Английский
Citations
1
Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101613 - 101613
Published: Feb. 25, 2025
Language: Английский
Citations
1
ACS Applied Bio Materials, Journal Year: 2023, Volume and Issue: 7(1), P. 44 - 58
Published: Dec. 18, 2023
Epithelial-mesenchymal transition (EMT) is a fundamental process driving cancer metastasis, transforming non-motile cells into motile population that migrates to distant organs and forms secondary tumors. In recent years, research has revealed strong connection between exosomes the EMT. Exosomes, subpopulation of extracellular vesicles, facilitate cellular communication dynamically regulate various aspects including immune cell suppression, matrix remodeling, metastasis initiation, EMT organ-specific metastasis. Tumor-derived (TEXs) their molecular cargo, comprising proteins, lipids, nucleic acids, carbohydrates, are essential components promote in cancer. TEXs miRNAs play crucial role reprogramming tumor microenvironment, while TEX surface integrins contribute Exosome-based offers deeper understanding about an effective theranostic platform development. Additionally, therapeutic sources paving way for innovative treatment this Review, we spotlight impact, aiming inspire researchers worldwide explore fascinating field more ways.
Language: Английский
Citations
21
ACS Measurement Science Au, Journal Year: 2024, Volume and Issue: 5(1), P. 31 - 55
Published: Nov. 15, 2024
Cancer immunotherapy is an innovative way of treating cancer by stimulating individual cells to overcome cancer. Widespread biomedical studies were carried out with the aim exploring therapeutics, and this review spotlights some mechanisms in which it was developed, namely immune checkpoint inhibitors (E.G PD-1/PD-L1, CTLA-4), adoptive cell therapy (e.g., CAR T-cell therapy), vaccines. Although has shown clinical benefit a number types, including melanoma non-small-cell lung cancer, several challenges have dampened enthusiasm for approach, from differing patient response rates toxicities. Nanotechnology drug delivery systems must play role overcoming same. enables increased specificity controlled release, improved solubility bioavailability, can treat tumor specifically, localized at disease site decreases systemic toxicity. The also features advances construction lipid-based, polymeric, inorganic nanoparticles that improve stability allow cotherapeutic agents. Nanotechnology-based be used alone or combination assist improving response, gaining access microenvironment, biological barriers. Thus, nano-DDS both safe effective preclinical studies, ongoing trials they are capable increasing therapeutic index anticancer drugs. Lastly, discusses current regulatory issues advancing these technologies highlights importance further research devise appropriate methodology efficient functionalization nanotechnology individualized solutions treatment.
Language: Английский
Citations
5
Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 453 - 470
Published: Jan. 1, 2025
Language: Английский
Citations
0
Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106761 - 106761
Published: March 1, 2025
Language: Английский
Citations
0
Heliyon, Journal Year: 2024, Volume and Issue: 10(5), P. e26759 - e26759
Published: Feb. 20, 2024
osteoporosis is a skeletal disorder disease features low bone mass and poor architecture, which predisposes to increased risk of fracture. Copper death newly recognized form cell caused by excess copper ions, presumably involve in various disease. Accordingly, we intended investigate the molecular clusters related cuproptosis construct predictive model.
Language: Английский
Citations
2
Heliyon, Journal Year: 2024, Volume and Issue: 10(9), P. e30380 - e30380
Published: April 26, 2024
AimTo explore the abundance and diversity of gut microbiota in patients with lung cancer accompanied by chronic obstructive pulmonary disease (LC-COPD).MethodsThe study cohort comprised 15 LC-COPD, 49 cancer, 18 healthy control individuals. ELISA was used to detect inflammatory factors venous blood. 16S rDNA sequencing performed determine microbiota. Gas chromatography–mass spectrometry concentration short-chain fatty acids (SCFAs) feces samples.ResultsThe α-diversity index indicated that richness were lower LC-COPD compared controls. Principal component analysis revealed significant differences among three groups (P < 0.05). The linear discriminant effect size algorithm o_Lactobacillales, g_Lactobaccillus, f_Lactobaccillaceae, s_Lactobaccillus_oris, c_Bacilli, g_Anaerofustis, s_uncultured organism, s_bacterium_P1C10 species prevalent while g_Clostridium_XIVa g_Butyricicoccus cancer. Furthermore, concentrations SCFAs butyric acid, isobutyric isovaleric valeric acid tended be controls, although these intergroup not > Patients had lowest serum tumor necrosis factor (TNF)-a. There no other factors.ConclusionsThe present structure is altered, may decreased LC-COPD. In addition, TNF-a.
Language: Английский
Citations
2
International Journal of Surgery, Journal Year: 2024, Volume and Issue: 110(10), P. 6432 - 6455
Published: July 4, 2024
This review explores the application of induced pluripotent stem cells (iPSCs) in regenerative medicine. The therapeutic significance iPSC-derived cell therapy within medicine, emphasizes their reprogramming process and crucial role cellular differentiation while setting purpose scope for comprehensive exploration therapy. subsequent sections intricately examine therapy, unravelling diverse derivatives iPSCs striking a delicate balance between advantages limitations applications. Mechanisms action, revealing how seamlessly integrate into tissues, induce regeneration, contribute to disease modeling drug screening advancements is discussed. analysis extends clinical trials, shedding light on outcomes, safety considerations, ethical dimensions. Challenges concerns, including risk tumorigenesis scalability issues, are explored. focus disease-specific applications, showcasing as promising avenue various medical conditions, supported by illustrative case studies. Future directions research needs outlined, identifying areas further exploration, considerations potential enhancements that will shape future landscape therapies. In conclusion, this provides significant understanding therapy's status, contemplates implications medicine personalized treatment using iPSCs, offering perspective evolving field confines dynamic scientific frontier.
Language: Английский
Citations
2
Heliyon, Journal Year: 2024, Volume and Issue: 10(7), P. e28442 - e28442
Published: March 22, 2024
Language: Английский
Citations
1