Recent Advances in Poly(vinyl alcohol)-Based Hydrogels

Polymers, Journal Year: 2024, Volume and Issue: 16(14), P. 2021 - 2021

Published: July 15, 2024

Poly(vinyl alcohol) (PVA) is a versatile synthetic polymer, used for the design of hydrogels, porous membranes and films. Its solubility in water, film- hydrogel-forming capabilities, non-toxicity, crystallinity excellent mechanical properties, chemical inertness stability towards biological fluids, superior oxygen gas barrier good printability availability (relatively low production cost) are main aspects that make PVA suitable variety applications, from biomedical pharmaceutical uses to sensing devices, packaging materials or wastewater treatment. However, pure present limited flexibility poor biocompatibility biodegradability, which restrict its use alone various applications. mixed with other polymers biomolecules (polysaccharides, proteins, peptides, amino acids etc.), as well inorganic/organic compounds, generates wide PVA’s shortcomings considerably improved, new functionalities obtained. Also, transformation brings features opens door unexpected uses. The review focused on recent advances PVA-based hydrogels.

Language: Английский

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Nanocellulose-based hydrogels as versatile materials with interesting functional properties for tissue engineering applications

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(32), P. 7692 - 7759

Published: Jan. 1, 2024

Tissue engineering has emerged as a remarkable field aiming to repair or replace damaged tissues through the use of biomimetic constructs.

Language: Английский

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Current Perspectives of Protein in Bone Tissue Engineering: Bone Structure, Ideal Scaffolds, Fabrication Techniques, Applications, Scopes, and Future Advances

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(8), P. 5082 - 5106

Published: July 15, 2024

In view of their exceptional approach, excellent inherent biocompatibility and biodegradability properties, interaction with the local extracellular matrix, protein-based polymers have received attention in bone tissue engineering, which is a multidisciplinary field that repairs regenerates fractured bones. Bone multihierarchical complex structure, it performs several essential biofunctions, including maintaining mineral balance structural support protecting soft organs. Protein-based gained interest developing ideal scaffolds as emerging biomaterials for healing regeneration, challenging to design substitutes perfect biomaterials. Several polymers, collagen, keratin, gelatin, serum albumin, etc., are potential materials due cytocompatibility, controlled biodegradability, high biofunctionalization, tunable mechanical characteristics. While numerous studies indicated encouraging possibilities proteins BTE, there still major challenges concerning stability physiological conditions, continuous release growth factors bioactive molecules. Robust derived from can be used replace broken or diseased biocompatible substitute; proteins, being biopolymers, provide engineering. Herein, recent developments protein cutting-edge engineering addressed this review within 3–5 years, focus on significant future perspectives. The first section discusses fundamentals anatomy scaffolds, second describes fabrication techniques scaffolds. third highlights importance applications BTE. Hence, development state-of-the-art has been discussed, highlighting

Language: Английский

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In Vitro Biocompatibility and Wound Healing Potential of Bilayered Scaffold With Electrospun Gentamicin‐Loaded Pullulan/PVA/Gum Arabic Nanofibers and Solvent‐Casted PLA

Journal of Applied Polymer Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

ABSTRACT Wound healing, especially for severe injuries, require dressings that absorb exudate, prevent infection, and support healing without causing trauma upon removal. Traditional single‐layered often fail to balance moisture retention protection, hindering optimal healing. To address this, a bilayered scaffold was fabricated comprising an electrospun hydrophilic sublayer of Pullulan/Polyvinyl alcohol (PVA)/Gum arabic blend loaded with Gentamicin solvent‐casted hydrophobic top layer Polylactic acid (PLA). The designed direct wound contact ease dressing removal, while the enhance mechanical properties, loss, protect against external environment. exhibited antibacterial activity Staphylococcus aureus Escherichia coli , controlled release 93.09% ± 2.63% within 48 h, best described by zero‐order model ( R 2 = 0.9850). It demonstrated swelling index 611.85% 15.05%, indicating its excellent exudate absorbing capacity. water vapor transmission rate (WVTR) porosity were 94.20 14.50 g/m /day 70.56% 0.58%, respectively, both falling permissible range Additionally, in vitro biocompatibility assays conducted on human dermal fibroblast (HDF) cells confirmed noncytotoxicity applicability applications.

Language: Английский

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Eco-friendly bio-nanocomposites: pioneering sustainable biomedical advancements in engineering

Discover Nano, Journal Year: 2024, Volume and Issue: 19(1)

Published: May 9, 2024

Biomedical nanocomposites, which are an upcoming breed of mischievous materials, have ushered in a new dimension the healthcare sector. Incorporating these materials tends to boost features this component already possesses and give might things components could not withstand alone. The biopolymer, carries nanoparticles, can simultaneously improve composite's stiffness biological characteristics, vice versa. This increases options composite number times it be used. bio-nanocomposites nanoparticles enable ecocompatibility medicine their biodegradability, they, way, ecological sustainability. outcome is improved properties its associated positive impact on environment. They broad applications antimicrobial agents, drug carriers, tissue regeneration, wound care, dentistry, bioimaging, bone filler, among others. dissertation elements emphasizes production techniques, diverse medicine, match-up issues, future-boasting prospects field. Through utilization such scientists develop more suitable for environment healthy biomedical solutions, world way improves as well.

Language: Английский

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Polydopamine reduced graphene oxide/ chitosan-based hydrogel for the therapy of diabetic wound

Materials Today Communications, Journal Year: 2024, Volume and Issue: 39, P. 109319 - 109319

Published: May 27, 2024

Language: Английский

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Metal-organic frameworks: synthesis, properties, wound dressing, challenges and scopes in advanced wound dressing

Biomedical Materials, Journal Year: 2024, Volume and Issue: 19(5), P. 052001 - 052001

Published: July 8, 2024

Abstract Wound healing is a critical but complex biological process of skin tissue repair and regeneration resulting from various systems working together at the cellular molecular levels. Quick wound problems associated with traditional techniques are being overcome multifunctional materials. Over time, this research area has drawn significant attention. Metal-organic frameworks (MOFs), owning to their peculiar physicochemical characteristics, now considered promising class well-suited porous materials for in addition other applications. This detailed literature review provides an overview latest developments MOFs We have discussed synthesis, essential biomedical properties, wound-healing mechanism, MOF-based dressing materials, The possible major challenges limitations been discussed, along conclusions future perspectives. addresses MOFs-based several angles covers most current subject. readers may discover how advanced discipline by producing more inventive, useful, successful dressings. It influences development generations biomaterials wounds.

Language: Английский

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Nano-encapsulation and characterizations of glimepiride drug with chitosan nanoparticles and its in vitro drug release kinetics and antidiabetic activity

Materials Today Communications, Journal Year: 2024, Volume and Issue: 39, P. 109333 - 109333

Published: May 23, 2024

Language: Английский

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Diaper-based wearable SERS sensing system with a silver nano dual-structure composite hydrogel for the detection of biomarkers and pH in urine

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155207 - 155207

Published: Aug. 26, 2024

Language: Английский

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Advancing wound healing by hydrogel-based dressings loaded with cell-conditioned medium: a systematic review

Stem Cell Research & Therapy, Journal Year: 2024, Volume and Issue: 15(1)

Published: Oct. 17, 2024

Wound healing represents a complex biological process, critically important in clinical practice due to its direct implication patient's recovery and quality of life. Conservative wound management frequently falls short providing an ideal environment for the optimal tissue regeneration, often resulting extended periods elevated risk infection other complications. The emerging biomaterials, particularly hydrogels, have shown substantial promise addressing these challenges by offering properties such as biocompatibility, biodegradability, ability cure environment. Recent advancements highlighted therapeutic potential integrating cell-derived conditioned medium (CM) into hydrogel matrices. Cell-derived CM rich array bioactive molecules, demonstrating significant efficacy modulating cellular activities crucial healing, including proliferation, migration, angiogenesis.

Language: Английский

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