Microchemical Journal, Journal Year: 2021, Volume and Issue: 167, P. 106305 - 106305
Published: April 19, 2021
Language: Английский
Current Medical Science, Journal Year: 2021, Volume and Issue: 41(6), P. 1037 - 1051
Published: July 9, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pathogen of disease 2019 (COVID-19), has caused more than 179 million infections and 3.8 deaths worldwide. Throughout past year, multiple vaccines have already been developed used, while some others are in process being developed. However, emergence new mutant strains SARS-CoV-2 that demonstrated immune-evading characteristics an increase infective capabilities leads to potential ineffectiveness against these variants. The purpose this review article is highlight current understanding immunological mechanisms virus vaccines, as well investigate key variants mutations driving pandemic their impacts on management guidelines. We also discussed technologies for prevention, treatment, detection SARS-CoV-2. In paper, we thoroughly reviewed provided crucial information virology, drugs used its prevention important variant strains. Our paper will be beneficial health care professionals researchers so they can a better basic sciences, clinical treatment COVID-19 during pandemic. This consists most updated available June 21, 2021.
Language: Английский
Citations
233
TrAC Trends in Analytical Chemistry, Journal Year: 2021, Volume and Issue: 145, P. 116452 - 116452
Published: Oct. 4, 2021
Language: Английский
Citations
145
Methods, Journal Year: 2021, Volume and Issue: 203, P. 431 - 446
Published: April 9, 2021
Language: Английский
Citations
120
Talanta, Journal Year: 2022, Volume and Issue: 252, P. 123773 - 123773
Published: Aug. 6, 2022
Aflatoxin B1 (AFB1) contamination in food threatens global safety, and rapid quantitative detection of AFB1 remains a challenge. Herein, novel fluorescence biosensor was developed for based on CRISPR/Cas12a MXenes. Specifically, the well-designed activator locked by dual-AFB1 aptamers, Cas12a directly linked to crRNA form inactivated complexes, MXenes efficiently adsorbed FAM fluorophore-modified single-stranded DNA (ssDNA-FAM), quenching its fluorescence. In presence AFB1, released due preferential binding aptamer then activated trans-cleavage activity indiscriminately cleave ssDNA MXenes, leading recovery signal. The fluorescent had wide range from 0.001 80 ng mL-1, limit 0.92 pg ability detect within min. More importantly, platform demonstrates excellent performance real peanut samples.
Language: Английский
Citations
94
International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 238, P. 124054 - 124054
Published: March 17, 2023
Language: Английский
Citations
84
Exploration, Journal Year: 2023, Volume and Issue: 3(1)
Published: Jan. 7, 2023
Coronavirus disease 2019 (COVID-19) pandemic has exemplified how viral growth and transmission are a significant threat to global biosecurity. The early detection treatment of infections is the top priority prevent fresh waves control pandemic. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) been identified through several conventional molecular methodologies that time-consuming require high-skill labor, apparatus, biochemical reagents but have low accuracy. These bottlenecks hamper methods from resolving COVID-19 emergency. However, interdisciplinary advances in nanomaterials biotechnology, such as nanomaterials-based biosensors, opened new avenues for rapid ultrasensitive pathogens field healthcare. Many updated namely electrochemical, field-effect transistor, plasmonic, colorimetric employ nucleic acid antigen-antibody interactions SARS-CoV-2 highly efficient, reliable, sensitive, manner. This systematic review summarizes mechanisms characteristics biosensors detection. Moreover, continuing challenges emerging trends biosensor development also discussed.
Language: Английский
Citations
52
TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: 173, P. 117654 - 117654
Published: March 13, 2024
Language: Английский
Citations
17
TrAC Trends in Analytical Chemistry, Journal Year: 2021, Volume and Issue: 143, P. 116377 - 116377
Published: June 24, 2021
Language: Английский
Citations
100
Nanomedicine, Journal Year: 2021, Volume and Issue: 16(6), P. 497 - 516
Published: March 1, 2021
COVID-19, as an emerging infectious disease, has caused significant mortality and morbidity along with socioeconomic impact. No effective treatment or vaccine been approved yet for this pandemic disease. Cutting-edge tools, especially nanotechnology, should be strongly considered to tackle virus. This review aims propose several strategies design fabricate diagnostic therapeutic agents against COVID-19 by the aid of nanotechnology. Polymeric, inorganic self-assembling materials peptide-based nanoparticles are promising tools battling well its rapid diagnosis. summarizes all exciting advances nanomaterials making toward prevention, diagnosis therapy.
Language: Английский
Citations
71
RSC Advances, Journal Year: 2021, Volume and Issue: 11(41), P. 25788 - 25794
Published: Jan. 1, 2021
The COVID-19 pandemic demonstrated the critical need for accurate and rapid testing virus detection. This has generated a high number of new methods aimed at replacing RT-PCR, which is golden standard testing. Most techniques are based on biochemistry require chemicals that often expensive supply might become scarce in large crisis. In present paper we suggest use physics leverage novel nanomaterials. We demonstrate using Surface Enhanced Raman Spectroscopy (SERS) virion particles very distinct spectroscopic signature SARS-CoV-2 can be obtained. spectra mainly composed by signals from spike (S) nucleocapsid (N) proteins. It believed clinical test SERS developed. will fast, inexpensive, reliable. also clear used analysis structural changes S N an example application nanotechnology properties nanoparticles health social related matters.
Language: Английский
Citations
70