Biosensors and Bioelectronics X, Journal Year: 2024, Volume and Issue: unknown, P. 100556 - 100556
Published: Oct. 1, 2024
Language: Английский
Biosensors, Journal Year: 2024, Volume and Issue: 14(7), P. 356 - 356
Published: July 22, 2024
The steady progress in consumer electronics, together with improvement microflow techniques, nanotechnology, and data processing, has led to implementation of cost-effective, user-friendly portable devices, which play the role not only gadgets but also diagnostic tools. Moreover, numerous smart devices monitor patients' health, some them are applied point-of-care (PoC) tests as a reliable source evaluation patient's condition. Current practices still based on laboratory tests, preceded by collection biological samples, then tested clinical conditions trained personnel specialistic equipment. In practice, collecting passive/active physiological behavioral from patients real time feeding artificial intelligence (AI) models can significantly improve decision process regarding diagnosis treatment procedures via omission conventional sampling while excluding pathologists. A combination novel methods digital traditional biomarker detection portable, autonomous, miniaturized revolutionize medical diagnostics coming years. This article focuses comparison modern techniques AI machine learning (ML). presented technologies will bypass laboratories start being commercialized, should lead or substitution current Their application PoC settings technology accessible every patient appears be possibility. Research this field is expected intensify Technological advancements sensors biosensors anticipated enable continuous real-time analysis various omics fields, fostering early disease intervention strategies. integration health platforms would predictive personalized healthcare, emphasizing importance interdisciplinary collaboration related scientific fields.
Language: Английский
Citations
27
ACS Applied Electronic Materials, Journal Year: 2025, Volume and Issue: 7(3), P. 1209 - 1216
Published: Jan. 30, 2025
Large-scale graphene films enable the integration of field-effect transistor (GFET) arrays onto chips. However, transfer characteristics display variability across array. This significant statistical variation in quality combined with lack standardized protocols poses a major challenge to commercialization. In this study, we present rapid, extensive, and high-resolution inspection technique using slit-scanning Raman microscopy. imaging all GFETs was performed before conducting electrical measurements. The G-band 2D-band peak positions were used determine hole carrier density (nH) GFETs. Variations nH values correlated VDP values, which is critical parameter FET performance, validating approach as an method. Moreover, peaks tracked 100 at different processing stages, revealing that spatial variations originated during wet-transfer process. method vital for scalable manufacturing devices.
Language: Английский
Citations
1
Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: March 9, 2025
Early and precise diagnosis of neurodegenerative disorders like Alzheimer's (AD) Parkinson's (PD) is crucial for slowing their progression enhancing patient outcomes. Exosomal microRNAs (miRNAs) are emerging as promising biomarkers due to ability reflect the diseases' pathology, yet low abundance poses significant detection hurdles. This review article delves into burgeoning field electrochemical biosensors, designed exosomal miRNA biomarkers. Electrochemical biosensors offer a compelling solution, combining sensitivity required detect low-abundance with specificity needed discern profiles distinctive neural pathological states. We explore operational principles these including transduction mechanisms that facilitate detection. The also summarizes advancements in nanotechnology, signal enhancement, bioreceptor anchoring, microfluidic integration improve sensor accuracy. evidence use disease analyzed, focusing on clinical impact, diagnostic precision, obstacles faced practical applications. Their potential point-of-care testing regulatory considerations market entry discussed. Looking toward future, highlights forthcoming innovations might revolutionize early processes. impressive sensitivity, specificity, compatibility, track become instrumental diseases, possibly transforming care prognosis.
Language: Английский
Citations
1
Plasmonics, Journal Year: 2025, Volume and Issue: unknown
Published: March 14, 2025
Language: Английский
Citations
1
Applied Physics Express, Journal Year: 2025, Volume and Issue: 18(2), P. 025003 - 025003
Published: Jan. 31, 2025
Abstract We investigate the effect of gate-source current ( I GS ) on variations in Dirac point voltage V DP electrolyte-gated graphene field-effect transistor (EG-GFET) arrays through a time-resolved analysis and an equivalent circuit model. Source/drain electrodes exposed to electrolyte induce substantial capacitive prolonged charging duration electric double-layer capacitance, which leads position-dependent variation relative gate electrode. The electrode-passivation alleviates by significantly reducing associated time. These findings offer critical insights for design integrated EG-GFET arrays.
Language: Английский
Citations
0
ACS Sensors, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 31, 2025
Epithelial cell adhesion molecule (EpCAM) was considered to be an important marker of multiple tumors, and its high expression is closely related the early diagnosis treatment tumors. At present, metal oxide semiconductors have become a key component biosensor bioelectronics technology. Tin shows great potential for development because nontoxic, nonpolluting, low price, excellent electrical properties. In this study, novel SnO2 solution-gated thin film transistor (SGTFT) specific detection EpCAM successfully developed using prepared by sol-gel method as channel material. By selecting optimal thickness 100 nm material, transconductance value (gm) reached 1432 μS, threshold voltage (Vth) remained stable at 0.288 V. order achieve qualitative quantitative EpCAM, films were subjected chemical fix aptamer. Through recognition between aptamer gate changes triggered regulate current device. FE-SEM, EIS, XPS, performance tests employed track measure modification process. Based on optimizations described above, SGTFT exhibited sensitivity (14.6 mV·dec-1), limit (LOD) down 24.4 pg/mL, calibration curves in range 0.02 ng/mL-500 ng/mL sensing. The SnO2-SGTFT anticipated provide new highly sensitive platform health monitoring disease diagnosis.
Language: Английский
Citations
0
ACS Sensors, Journal Year: 2025, Volume and Issue: unknown
Published: March 19, 2025
With the goal of impacting patient quality life and outcomes, sensor science offers significant potential to revolutionize healthcare by providing advances in detection molecular biomarkers for personalized clinical technologies. The community has achieved technical advancements that can impact diagnostics, health monitoring, disease treatment; however, many innovations remain confined laboratory, failing bridge translational gap between research real-world applications. This perspective presents a new direction community, where development centers on needs experiences primary beneficiaries: patients. We provide guidelines resources researchers engage with patients early continuously throughout process inform specifications better align technologies needs, improving their adoption impact. also present examples implementing patient-centered approach planning engagement research. In design impactful sensors patients, must expand focus beyond embrace approach, which will likely lead opportunities collaboration evolution community.
Language: Английский
Citations
0
Biosensors, Journal Year: 2025, Volume and Issue: 15(5), P. 269 - 269
Published: April 24, 2025
Colloidal quantum dots (QDs) and graphene hybrids have emerged as promising platforms for optoelectronic biosensing applications due to their unique photophysical electronic properties. This study investigates the fundamental mechanism underlying photoluminescence (PL) quenching recovery in graphene–QD hybrid systems using single-layer field-effect transistors (SLG-FETs) time-resolved (TRPL) spectroscopy. We demonstrate that PL its are primarily driven by charge transfer, evidenced an unchanged fluorescence lifetime upon quenching. Density functional theory calculations reveal a significant redistribution at interface, corroborating experimental observations. also provide simple analytical mechanical model differentiate transfer-induced from resonance energy transfer. Furthermore, we leverage transfer ultrasensitive detect biomarkers such immunoglobulin G (IgG) femtomolar concentrations. The sensor’s electrical response, characterized systematic shifts Dirac point of SLG-FETs, confirms role analyte-induced modulation recovery. Our findings framework designing next-generation graphene-based biosensors with exceptional sensitivity specificity.
Language: Английский
Citations
0
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: April 29, 2025
With the increasing limitations of conventional computing techniques, particularly von Neumann bottleneck, brain's seamless integration memory and processing through synapses offers a valuable model for technological innovation. Inspired by biological synapse facilitating adaptive, low-power computation modulating signal transmission via ionic conduction, iontronic synaptic devices have emerged as one most promising candidates neuromorphic computing. Meanwhile, atomic-scale thickness tunable electronic properties van der Waals two-dimensional (2D) materials enable possibility designing highly integrated, energy-efficient that closely replicate plasticity. This review comprehensively analyzes advancements in based on 2D materials, focusing electron-ion interactions both transistors memristors. The challenges material stability, scalability, device are evaluated, along with potential solutions future research directions. By highlighting these developments, this insights into advancing systems.
Language: Английский
Citations
0
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(52)
Published: Nov. 20, 2024
Due to their ultra-high sensitivity, solution-gated graphene-based field-effect transistors (SG-GFET) have been proposed for applications in bio-sensing. However, challenges regarding the functionalization of GFETs prevented clinical diagnostics so far. Here GFET sensors based on van der Waals (vdW) heterostructures single-layer graphene layered with a molecular ≈1 nm thick carbon nanomembrane (CNM) are presented. The CNM acts as an ultrathin interposer between channel and analyte allows bio-functionalization without impairing properties including its charge carrier mobility. To achieve specificity reliability detection biomarkers real patient samples, incorporates biostable aptamers non-natural l-configuration hydrophilic polyethylene glycol avoiding non-specific adsorption. A rapid (≈5 min) clinically relevant inflammatory mediator CXCL8/IL-8 within concentration range 0.5 - 500 pM (5 5000 pg ml-1) is demonstrated nasal swab samples collected from patients respiratory tract infections. This may aid early-stage infectious diseases making reported approach promising development future medical tools.
Language: Английский
Citations
2