High-Order Harmonics and Photoluminescence in Azo-Phenylthiophene Derivatives DOI
S. Taboukhat, A. Aamoum, Awatef Ayadi

et al.

The Journal of Physical Chemistry C, Journal Year: 2024, Volume and Issue: 128(46), P. 19839 - 19848

Published: Nov. 7, 2024

This paper presents the linear and nonlinear optical (NLO) properties of two donor–acceptor organic materials, namely, N,N-dimethyl-4-((E)-(4-((E)-((5-phenylthiophen-2-yl)methylene)amino)phenyl)diazenyl)aniline A (E)-4-((E)-(4-nitrophenyl)diazenyl)-N-((5-phenylthiophen-2-yl)methylene)aniline B. The studied compounds differ from each other by nature substituent (donor or acceptor) on azobenzene moiety, giving rise to D−π–D D−π–A systems, respectively, for thin-film deposition process was carried out using different techniques: physical vapor (PVD) spin-coating. aim this work is elucidate influence both molecular structure technique their responses. Absorbance, photoluminescence, decay time were used measure properties, while second third harmonic generation techniques as tools comparison results obtained B indicates a much better NLO performance with value 8.18 ± 0.09 pm V–1 compound shape 1.32 0.07 structure. more detailed analysis revealed noteworthy finding: exhibited considerably elevated third-order susceptibility values in reference material, discrepancies spanning 1–2 orders magnitude. Of particular interest B, which demonstrated highest χ(3)elec equal (225.91 0.92) × 10–22 m2 V–2. research completed theoretical quantum chemical calculations, included determination dipole moments evaluation orbital frontier occupied lowest unoccupied energies. These comprehensive studies demonstrate significant potential azo-based phenylthiophene derivatives optoelectronics optics applications also show that it valuable candidate production light-emitting diodes.

Language: Английский

Multi‐Enzyme Nanoparticles as Efficient Pyroptosis and Immunogenic Cell Death Inducers for Cancer Immunotherapy DOI Creative Commons

Hekai Yang,

Guangzhao Xu, Fahui Li

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(44)

Published: Oct. 9, 2024

Abstract Immunotherapy represents a widely employed modality in clinical oncology, leveraging the activation of human immune system to target and eradicate cancer cells tumor tissues via endogenous mechanisms. However, its efficacy remains constrained by inadequate responses within “cold” microenvironment (TME). In this study, multifunctional nanoscale pyroptosis inducer with cascade enzymatic activity (IMZF), comprising superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), glutathione oxidase (GSHO x ), is dissociated acidic glutathione‐rich TME. The vigorous not only generates oxygen (O 2 ) alleviate hypoxia promote M2 M1 macrophage polarization but also yields reactive species (ROS) depletes (GSH) Functioning as an immunogenic cell death (ICD) activator inducer, IMZF synergistically triggers dendritic maturation inflammatory lymphocyte infiltration ICD‐associated pyroptosis, thereby reversing suppression TMEs. Consequently, it exerts inhibitory effects on both primary distal tumors. This platform‐based offers intelligent strategy for effectively overcoming tumors, providing promising avenue advanced immunotherapeutic interventions.

Language: Английский

Citations

7
Design strategies and applications of cyanine dyes in phototherapy DOI
Jie Yuan, Han‐xue Yang,

Wenhui Huang

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

An overview of cyanine dye-based phototherapy agents, including the design strategies, relationships between molecular structures and properties, as well applications in photodynamic therapy, photothermal multimodal combined therapy.

Language: Английский

Citations

6
Molecular Engineering of NIR-II Excitable Phototheranostic for Mitochondria-Targeted Cancer Photoimmunotherapy DOI
Qiang Kang, Fen Liu, Senyou Tan

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

The advancement of mitochondria-targeted near-infrared-II (NIR-II) excitable phototheranostics constitutes a promising strategy for improving fluorescence-image-guided cancer phototherapy. However, developing phototheranostic agents that simultaneously combine high-contrast NIR-II fluorescence imaging with effective multimodal therapeutic techniques remains substantial challenge. Herein, we reported shielding-donor-acceptor-donor-shielding structured (FCD-T) by molecular engineering strategy, followed self-assembly glutathione-responsive copolymer to form FCD-T nanoparticles. introduction functional bithiophene endows significant electron-donating properties and reduces intermolecular π-π stacking interactions. robust π-conjugation fluorene good rigidity would enhance the intramolecular charge transfer capability. Therefore, NPs exhibited an absorption peak at 1075 nm emission 1280 nm. Upon light excitation, such nanoparticles could generate excellent photothermal photodynamic performances biocompatibility. Moreover, phototherapy further facilitated mitochondrial apoptosis-related pathways, activating antitumor immunity inhibiting tumor growth single irradiation low doses.

Language: Английский

Citations

0
Development of small-molecule NIR-II photothermal agents for image-guided tumor therapy DOI
Long He, Yi Li,

Chonghua Zhang

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 533, P. 216549 - 216549

Published: Feb. 27, 2025

Language: Английский

Citations

0
Exceptional Near-Infrared II Organic Small Molecule Nanoagent for Photoacoustic/Photothermal Imaging-Guided Highly Efficient Therapy in Cancer DOI

Yidong Bin,

Lixian Huang, Jiang‐Ke Qin

et al.

Bioconjugate Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Near-infrared II (NIR-II) photoacoustic (PA)/photothermal imaging-guided tumor therapy holds great promise in precision medicine for cancer treatment. This work reports on the synthesis and application of an organic small molecule nanoagent that has exceptional PA photothermal properties near-infrared region. BCy-TPE was constructed by linking NIR-II absorbing cyanine dye BCy-Cl with a twisted tetraphenylethene unit. The synthesized exhibited intense absorption peak at 1032 nm. After encapsulation into water-dispersible nanoparticles (NPs), NPs two peaks 880 1046 Notably, under 1064 nm laser excitation, deliver remarkable conversion efficiency 92%, together superior biocompatibility, photostability, PA/photothermal imaging capability. Moreover, after intravenous administration 4T1 tumor-bearing mice treatment safe-intensity (1.0 W cm-2 nm) irradiation, temperature increased rapidly to 52 °C within 1 min tumors are completely ablated single Overall, this offers novel strategy develop superb agents highly efficient cancer.

Language: Английский

Citations

0
High-Order Harmonics and Photoluminescence in Azo-Phenylthiophene Derivatives DOI
S. Taboukhat, A. Aamoum, Awatef Ayadi

et al.

The Journal of Physical Chemistry C, Journal Year: 2024, Volume and Issue: 128(46), P. 19839 - 19848

Published: Nov. 7, 2024

This paper presents the linear and nonlinear optical (NLO) properties of two donor–acceptor organic materials, namely, N,N-dimethyl-4-((E)-(4-((E)-((5-phenylthiophen-2-yl)methylene)amino)phenyl)diazenyl)aniline A (E)-4-((E)-(4-nitrophenyl)diazenyl)-N-((5-phenylthiophen-2-yl)methylene)aniline B. The studied compounds differ from each other by nature substituent (donor or acceptor) on azobenzene moiety, giving rise to D−π–D D−π–A systems, respectively, for thin-film deposition process was carried out using different techniques: physical vapor (PVD) spin-coating. aim this work is elucidate influence both molecular structure technique their responses. Absorbance, photoluminescence, decay time were used measure properties, while second third harmonic generation techniques as tools comparison results obtained B indicates a much better NLO performance with value 8.18 ± 0.09 pm V–1 compound shape 1.32 0.07 structure. more detailed analysis revealed noteworthy finding: exhibited considerably elevated third-order susceptibility values in reference material, discrepancies spanning 1–2 orders magnitude. Of particular interest B, which demonstrated highest χ(3)elec equal (225.91 0.92) × 10–22 m2 V–2. research completed theoretical quantum chemical calculations, included determination dipole moments evaluation orbital frontier occupied lowest unoccupied energies. These comprehensive studies demonstrate significant potential azo-based phenylthiophene derivatives optoelectronics optics applications also show that it valuable candidate production light-emitting diodes.

Language: Английский

Citations

0