Toxicology Reports,
Journal Year:
2024,
Volume and Issue:
14, P. 101862 - 101862
Published: Dec. 11, 2024
Fibroblasts
are
considered
a
key
player
in
the
wound
healing
process.
Although
this
cellular
family
is
constituted
by
several
distinct
subtypes,
dermal
fibroblasts
crucial
thanks
to
their
ability
secrete
pro-regenerative
growth
factors,
extracellular
matrix
(ECM)
proteins
and
immune
anti-inflammatory
role.
Sophorolipids
(SL),
sophorosides
(SS)
glucolipids
(G),
mono-unsaturated
(C18:1)
or
saturated
(C18:0),
glycolipids
derived
from
microbial
fermentation
of
wild
type
engineered
yeast
Starmerella
bombicola,
constitute
novel
sustainable
class
bio-based
chemicals
with
interesting
physicochemical
characteristics,
which
allow
them
form
soft
diverse
structures
hydrogels
vesicles,
micelles
complex
coacervates
potential
interest
skin
regeneration
applications.
In
study,
we
first
tested
cytocompatibility
broad
set
molecules
on
normal
human
(NHDF).
Our
results
show
that,
up
an
upper
threshold
(0.1
%
w/v),
(SL-C18:1,
G-C18:1,
SSbola-C18:1,
SL-C18:0
G-C18:0)
under
study
were
able
sustain
cell
growth.
Furthermore,
selected
least
cytotoxic
SL-C18:0)
promote
measuring
gene
expression
markers
(i.e.
collagen,
elastin,
transforming
factor
β,
fibroblast
…)
using
qPCR.
Unfortunately,
none
these
modulated
involved
tissue
repair.
However,
aims
encourage
community
test
for
high-end
biomedical
Biosurfactants
prepared
natural
amphiphiles
growing
importance,
goal
replacing
synthetic
surfactants
commercial
formulations.
cytotoxicity
profile
still
poorly
known,
especially
new
like
single-glucose
lipids
bolaform
sophorolipids.
This
wants
contribute
all
those
applications,
could
be
developed
biosurfactants
contact
(cosmetics,
healing).
We
five
structurally-related
(C18:1
C18:0
sophorolipids,
C18:1
lipids,
di-sophoroside)
against
(NHDF)
evaluate
metabolic
activity
toxic
among
them.
To
best
our
knowledge,
molecules,
general,
was
never
NHDF.
Journal of Sol-Gel Science and Technology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 28, 2025
Abstract
A
rapid
development
strategy
was
successfully
implemented
to
create
a
suEPSR111459pramolecular
metallogel
comprising
Mn(II)
(referred
as
MnA-TA)
and
Zn(II)
ZnA-TA)
ions.
These
gels
were
formed
using
L-(+)-tartaric
acid
low
molecular
weight
gelator
in
DMF
medium
at
ambient
conditions.
Rheological
analysis
employed
assess
the
mechanical
stability
of
synthesized
MnA-TA
ZnA-TA
metallogel.
The
results
revealed
gel’s
impressive
resilience
when
subjected
various
angular
frequencies
levels
oscillator
stress.
exploration
metallogel’s
distinct
morphological
patterns
conducted
FESEM
images.
that
exhibited
flake-like
hierarchical
network
structure,
while
demonstrated
diamond-shaped
architecture.
EDX
utilized
for
elemental
mapping,
confirming
presence
primary
chemical
constituents
metallogels.
formation
nature
gel
materials
examined
through
FT-IR
spectroscopy
PXRD
analysis.
metallogels
semiconducting
properties,
confirmed
by
optical
band-gap
measurements.
Furthermore,
metal-semiconductor
junction-based
device
fabricated
combining
Al
metal
with
Mn(II)-
Zn(II)-metallogels.
displayed
nonlinear
charge
transport
behavior,
resembling
Schottky
diode,
evidenced
its
I-V
characteristic.
This
indicates
potential
use
sandwich-like
configuration
ITO/MnA-TA
metallogel/Al
ITO/ZnA-TA
advanced
electronic
devices
based
on
supramolecular
Notably,
direct
utilization
tartaric
Mn(II)/Zn(II)
sources
presents
an
innovative
approach,
highlighting
their
suitability
fabrication.
study
delves
into
multifunctional
applications
metallogels,
providing
valuable
insights
researchers
field
material
science.
Graphical
Soft Matter,
Journal Year:
2022,
Volume and Issue:
19(3), P. 378 - 393
Published: Dec. 23, 2022
Low-molecular
weight
gelators
(LMWGs)
are
small
molecules
(Mw
<
∼1
kDa),
which
form
self-assembled
fibrillar
network
(SAFiN)
hydrogels
in
water
when
triggered
by
an
external
stimulus.
A
great
majority
of
SAFiN
gels
involve
entangled
fibers,
analogy
to
a
polymer
good
solvent.
In
some
rare
cases,
combination
attractive
van
der
Waals
and
repulsive
electrostatic
forces
drives
the
formation
bundles
with
suprafibrillar
hexagonal
order.
this
work,
unexpected
micelle-to-fiber
transition
is
Ca2+
or
Ag+
ions
added
micellar
solution
novel
glycolipid
surfactant,
whereas
salt-induced
fibrillation
not
common
for
surfactants.
The
resulting
SAFiN,
forms
hydrogel
above
0.5
wt%,
has
"nano-fishnet"
structure,
characterized
fibrous
both
fibers
β-sheet-like
rafts,
generally
observed
silk
fibroin,
actin
mineral
imogolite
nanotubes,
but
known
SAFiNs.
raft
domains
cryo-TEM
SAXS
seem
contribute
stability
gels.
Furthermore,
obtained
fermentation
from
natural
resources
(glucose,
rapeseed
oil),
thus
showing
that
naturally
engineered
compounds
can
have
unprecedented
properties,
compared
wide
range
chemically
derived
amphiphiles.
The Journal of Physical Chemistry B,
Journal Year:
2022,
Volume and Issue:
126(49), P. 10528 - 10542
Published: Dec. 7, 2022
Biological
amphiphiles
are
molecules
with
a
rich
phase
behavior.
Micellar,
vesicular,
and
even
fibrillar
phases
can
be
found
for
the
same
molecule
by
applying
change
in
pH
or
selecting
appropriate
metal
ion.
The
behavior
paves
way
toward
broad
class
of
soft
materials,
from
carriers
to
hydrogels.
present
work
contributes
understanding
fibrillation
microbial
glycolipid,
glucolipid
G-C18:1,
produced
Starmerella
bombicola
ΔugtB1
characterized
micellar
at
alkaline
vesicular
acidic
pH.
Fibrillation
prompt
hydrogelation
is
triggered
adding
either
earth,
Ca2+,
transition
metal,
Ag+,
Fe2+,
Al3+,
ions
G-C18:1
solution.
A
specifically
designed
apparatus
coupled
synchrotron
SAXS
beamline
allows
performing
simultaneous
cation-
pH-resolved
situ
monitoring
morphological
evolution
spheroidal
micelles
crystalline
fibers,
when
Ca2+
employed,
wormlike
aggregates,
Fe2+
Al3+
solutions
employed.
fast
reactivity
Ag+
crystallinity
Ca2+-induced
fibers
suggest
that
driven
direct
metal–ligand
interactions,
while
shape
elongated
rather
charge
screening
between
lipid
hydroxylated
cation
species.
Soft Matter,
Journal Year:
2022,
Volume and Issue:
19(3), P. 366 - 377
Published: Dec. 12, 2022
Low-molecular
weight
gelators
(LMWGs)
are
small
molecules
(Mw
<
∼1
kDa),
which
form
self-assembled
fibrillar
network
(SAFiN)
hydrogels
in
water.
A
great
majority
of
SAFiN
gels
described
by
an
entangled
fibers,
analogy
to
a
polymer
good
solvent.
Here,
fibrillation
biobased
glycolipid
bolaamphiphile
is
triggered
Ca2+
or
Ag+
ions
added
its
diluted
micellar
phase.
The
resulting
SAFiN,
forms
hydrogel
above
0.5
wt%,
has
"nano-fishnet"
structure,
characterized
fibrous
both
fibers
and
β-sheet-like
rafts,
generally
observed
for
silk
fibroin,
actin
mineral
imogolite
nanotubes,
but
not
known
SAFiN.
This
work
focuses
on
the
strength
SAFIN
gels,
their
fast
recovery
after
applying
mechanical
stimulus
(strain)
unusual
resistance
temperature,
studied
coupling
rheology
angle
X-ray
scattering
(rheo-SAXS)
using
synchrotron
radiation.
Ca2+-based
maintains
properties
up
55
°C,
while
Ag+-based
gel
shows
constant
elastic
modulus
70
without
appearance
any
gel-to-sol
transition
temperature.
Furthermore,
obtained
fermentation
from
natural
resources
(glucose
rapeseed
oil),
thus
showing
that
naturally
engineered
compounds
can
have
unprecedented
properties,
when
compared
wide
range
chemically
derived
amphiphiles.
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(27), P. 5470 - 5510
Published: Jan. 1, 2024
The
synthesis
of
carbohydrate-derived
self-assembling
systems
and
the
properties
resulting
stimulus-responsive
materials
via
bottom-up
approaches
are
reviewed.
