Scientific Reports,
Journal Year:
2014,
Volume and Issue:
4(1)
Published: July 10, 2014
Protein
misfolding
and
aggregation
are
associated
with
more
than
twenty
diseases,
such
as
neurodegenerative
diseases
metabolic
diseases.
The
amyloid
oligomers
fibrils
may
induce
cell
membrane
disruption
lead
to
apoptosis.
A
great
number
of
studies
have
focused
on
discovery
inhibitors
which
prevent
or
treat
amyloidosis
Polyphenols
been
extensively
studied
a
class
inhibitors,
several
polyphenols
under
clinical
trials
anti-neurodegenerative
drugs.
As
oxidative
intermediates
natural
polyphenols,
quinones
widely
exist
in
medicinal
plants
food.
In
this
study,
we
used
insulin
an
model
test
the
anti-amyloid
effects
four
simple
anthraquinone
derivatives
from
rhubarb,
traditional
herbal
medicine
for
treating
Alzheimer's
disease.
Our
results
demonstrated
that
all
eight
show
inhibitory
different
extent
oligomerization,
especially
1,4-benzoquinone
1,4-naphthoquinone.
Significantly
attenuated
reduced
amount
hemolysis
levels
were
found
after
treatments,
indicating
inhibit
forming
toxic
oligomeric
species.
suggest
potential
action
native
preventing
protein
quinone
skeleton
thus
be
further
explored
designing
effective
anti-amyloidosis
compounds.
Chemical Society Reviews,
Journal Year:
2015,
Volume and Issue:
44(13), P. 4400 - 4414
Published: Jan. 1, 2015
The
potent
redox
activity
of
copper
is
required
for
sustaining
life.
Mismanagement
its
cellular
pools,
however,
can
result
in
oxidative
stress
and
damage
connected
to
aging,
neurodegenerative
diseases,
metabolic
disorders.
Therefore,
homeostasis
tightly
regulated
by
cells
tissues.
Whereas
other
transition
metal
ions
are
commonly
thought
as
static
cofactors
buried
within
protein
active
sites,
emerging
data
points
the
presence
additional
loosely
bound,
labile
pools
that
participate
dynamic
signalling
pathways.
Against
this
backdrop,
we
review
advances
sensing
understanding
their
functions
using
synthetic
fluorescent
indicators.
Following
brief
introductions
considerations
sensor
design,
survey
available
probes
evaluate
properties
context
utility
effective
biological
screening
tools.
We
emphasize
need
combined
chemical
evaluation
these
reagents,
well
value
complementing
probe
with
techniques
characterizing
different
systems.
This
holistic
approach
will
maximize
exciting
opportunities
related
technologies
study
discovery
novel
biology
metals.
Chemical Reviews,
Journal Year:
2018,
Volume and Issue:
119(2), P. 1221 - 1322
Published: Aug. 10, 2018
Neurodegenerative
diseases
pose
a
substantial
socioeconomic
burden
on
society.
Unfortunately,
the
aging
world
population
and
lack
of
effective
cures
foreshadow
negative
outlook.
Although
large
amount
research
has
been
dedicated
to
elucidating
pathologies
neurodegenerative
diseases,
their
principal
causes
remain
elusive.
Metal
ion
dyshomeostasis,
proteopathy,
oxidative
stress,
neurotransmitter
deficiencies
are
pathological
features
shared
across
multiple
disorders.
In
addition,
these
factors
proposed
be
interrelated
upon
disease
progression.
Thus,
development
multifunctional
compounds
capable
simultaneously
interacting
with
several
components
suggested
as
solution
undertake
complex
diseases.
this
review,
we
outline
discuss
possible
therapeutic
targets
in
Alzheimer's
disease,
Parkinson's
amyotrophic
lateral
sclerosis
molecules,
previously
designed
or
discovered
potential
drug
candidates
for
disorders
emphasis
multifunctionality.
underrepresented
areas
discussed
indicate
new
directions.
Biomolecules,
Journal Year:
2014,
Volume and Issue:
4(1), P. 252 - 267
Published: Feb. 25, 2014
While
the
toxicity
of
metals
and
metalloids,
like
arsenic,
cadmium,
mercury,
lead
chromium,
is
undisputed,
underlying
molecular
mechanisms
are
not
entirely
clear.
General
consensus
holds
that
proteins
prime
targets;
heavy
interfere
with
physiological
activity
specific,
particularly
susceptible
proteins,
either
by
forming
a
complex
functional
side
chain
groups
or
displacing
essential
metal
ions
in
metalloproteins.
Recent
studies
have
revealed
an
additional
mode
action
targeted
at
non-native
state;
certain
metalloids
been
found
to
inhibit
vitro
refolding
chemically
denatured
protein
folding
vivo
cause
aggregation
nascent
living
cells.
Apparently,
unfolded
motile
backbone
chains
considerably
more
prone
engage
stable,
pluridentate
complexes
than
native
their
well-defined
3D
structure.
By
interfering
process,
profoundly
affect
homeostasis
cell
viability.
This
review
describes
how
impede
promote
aggregation,
cells
regulate
quality
control
systems
protect
themselves
from
might
contribute
misfolding
disorders.
Chemical Communications,
Journal Year:
2015,
Volume and Issue:
51(70), P. 13434 - 13450
Published: Jan. 1, 2015
Our
Feature
Article
details
the
physiological
role
of
amyloid
beta
(Aβ),
elaborates
its
toxic
effects
and
outlines
therapeutic
molecules
designed
in
last
two
years
targeting
different
aspects
Aβ
for
preventing
AD.
AIMS neuroscience,
Journal Year:
2020,
Volume and Issue:
8(1), P. 86 - 132
Published: Dec. 16, 2020
Alzheimer
disease
is
a
progressive
neurodegenerative
disorder,
mainly
affecting
older
people,
which
severely
impairs
patients'
quality
of
life.
In
the
recent
years,
number
affected
individuals
has
seen
rapid
increase.
It
estimated
that
up
to
107
million
subjects
will
be
by
2050
worldwide.
Research
in
this
area
revealed
lot
about
biological
and
environmental
underpinnings
Alzheimer,
especially
its
correlation
with
β-Amyloid
Tau
related
mechanics;
however,
precise
molecular
events
pathways
behind
are
yet
discovered.
review,
we
focus
our
attention
on
mechanics
may
lie
development.
particular,
briefly
describe
genetic
elements
discuss
specific
processes
potentially
associated
disease.
Advanced Materials,
Journal Year:
2020,
Volume and Issue:
32(51)
Published: Sept. 9, 2020
Abstract
Neurodegenerative
diseases
are
debilitating
disorders
that
feature
progressive
and
selective
loss
of
function
or
structure
anatomically
physiologically
associated
neuronal
systems.
Both
chronic
acute
neurodegenerative
with
high
morbidity
mortality
along
the
death
neurons
in
different
areas
brain;
moreover,
there
few
no
effective
curative
therapy
options
for
treating
these
disorders.
There
is
an
urgent
need
to
diagnose
disease
as
early
possible,
distinguish
between
overlapping
symptoms
will
help
decide
best
clinical
treatment.
Recently,
research,
fluorescent‐probe‐mediated
biomarker
visualization
techniques
have
been
gaining
increasing
attention
diagnosis
diseases.
A
survey
fluorescent
probes
sensing
imaging
biomarkers
provided.
These
categorized
based
on
potential
various
diseases,
their
advantages
disadvantages
discussed.
Guides
develop
new
strategies,
recognition
mechanisms,
well
ideal
features
further
improve
fluorescence
also
explored.
