Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints

Annual Review of Biochemistry, Journal Year: 2004, Volume and Issue: 73(1), P. 39 - 85

Published: June 1, 2004

▪ Abstract DNA damage is a relatively common event in the life of cell and may lead to mutation, cancer, cellular or organismic death. Damage induces several responses that enable either eliminate cope with activate programmed death process, presumably cells potentially catastrophic mutations. These response reactions include: (a) removal restoration continuity duplex; (b) activation checkpoint, which arrests cycle progression so as allow for repair prevention transmission damaged incompletely replicated chromosomes; (c) transcriptional response, causes changes transcription profile be beneficial cell; (d) apoptosis, eliminates heavily seriously deregulated cells. mechanisms include direct repair, base excision nucleotide double-strand break cross-link repair. The checkpoints employ sensor proteins, such ATM, ATR, Rad17-RFC complex, 9-1-1 detect initiate signal transduction cascades Chk1 Chk2 Ser/Thr kinases Cdc25 phosphatases. transducers p53 inactivate cyclin-dependent inhibit from G1 S (the G1/S checkpoint), replication intra-S G2 mitosis G2/M checkpoint). In this review molecular mammalian are analyzed.

Language: Английский

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Proton-Coupled Electron Transfer

Chemical Reviews, Journal Year: 2012, Volume and Issue: 112(7), P. 4016 - 4093

Published: June 18, 2012

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTProton-Coupled Electron TransferDavid R. Weinberg†§, Christopher J. Gagliardi†, Jonathan F. Hull†, Christine Fecenko Murphy‡, Caleb A. Kent†, Brittany C. Westlake∥, Amit Paul†, Daniel H. Ess†, Dewey Granville McCafferty*‡, and Thomas Meyer*†View Author Information† Department of Chemistry, University North Carolina at Chapel Hill, 27599-3290, United States‡ B219 Levine Science Research Center, Box 90354, Duke University, Durham, 27708-0354, States§ Physical Environmental Sciences, Colorado Mesa 1100 Avenue, Grand Junction, 81501-3122, States∥ The American Chemical Society, 1155 Sixteenth Street NW, Washington, District Columbia 20036, States*E-mail: [email protected]Cite this: Chem. Rev. 2012, 112, 7, 4016–4093Publication Date (Web):June 18, 2012Publication History Received19 May 2011Published online18 June 2012Published inissue 11 July 2012https://pubs.acs.org/doi/10.1021/cr200177jhttps://doi.org/10.1021/cr200177jreview-articleACS PublicationsCopyright © 2012 SocietyRequest reuse permissionsArticle Views44915Altmetric-Citations1339LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated by Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page altmetric.com with additional details score social media presence for given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Charge transfer,Oxidation,Proton coupled electron transfer,Reaction mechanisms,Redox reactions Get e-Alerts

Language: Английский

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Light Signal Transduction in Higher Plants

Annual Review of Genetics, Journal Year: 2004, Volume and Issue: 38(1), P. 87 - 117

Published: Nov. 2, 2004

Plants utilize several families of photoreceptors to fine-tune growth and development over a large range environmental conditions. The UV-A/blue light sensing phototropins mediate responses enabling optimization photosynthetic yields. initial event occurring upon photon capture is conformational change the photoreceptor that activates its protein kinase activity. cryptochromes red/far-red phytochromes coordinately control seedling establishment, entrainment circadian clock, transition from vegetative reproductive growth. In addition, seed germination shade-avoidance responses. molecular mechanisms involved include light-regulated subcellular localization photoreceptors, reorganization transcriptional program, proteolytic degradation signaling components.

Language: Английский

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Radical Initiation in the Class I Ribonucleotide Reductase: Long-Range Proton-Coupled Electron Transfer?

Chemical Reviews, Journal Year: 2003, Volume and Issue: 103(6), P. 2167 - 2202

Published: May 24, 2003

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRadical Initiation in the Class I Ribonucleotide Reductase: Long-Range Proton-Coupled Electron Transfer?JoAnne Stubbe, Daniel G. Nocera, Cyril S. Yee, and Michelle C. Y. ChangView Author Information Department of Chemistry, 77 Massachusetts Avenue, Institute Technology, Cambridge, 02139-4307 Cite this: Chem. Rev. 2003, 103, 6, 2167–2202Publication Date (Web):May 24, 2003Publication History Received16 January 2003Published online24 May inissue 1 June 2003https://pubs.acs.org/doi/10.1021/cr020421uhttps://doi.org/10.1021/cr020421uresearch-articleACS PublicationsCopyright © 2003 American Chemical SocietyRequest reuse permissionsArticle Views7657Altmetric-Citations730LEARN ABOUT THESE METRICSArticle Views are COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated by Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence for given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Charge transfer,Genetics,Monomers,Peptides proteins,Redox reactions Get e-Alerts

Language: Английский

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The Cryptochromes: Blue Light Photoreceptors in Plants and Animals

Annual Review of Plant Biology, Journal Year: 2011, Volume and Issue: 62(1), P. 335 - 364

Published: March 3, 2011

Cryptochromes are flavoprotein photoreceptors first identified in Arabidopsis thaliana, where they play key roles growth and development. Subsequently prokaryotes, archaea, many eukaryotes, cryptochromes function the animal circadian clock proposed as magnetoreceptors migratory birds. closely structurally related to photolyases, evolutionarily ancient flavoproteins that catalyze light-dependent DNA repair. Here, we review structural, photochemical, molecular properties of cry-DASH, plant, relation biological signaling mechanisms uncover common features may contribute better understanding diverse systems including man.

Language: Английский

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RadicalS-Adenosylmethionine Enzymes

Chemical Reviews, Journal Year: 2014, Volume and Issue: 114(8), P. 4229 - 4317

Published: Jan. 29, 2014

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTRadical S-Adenosylmethionine EnzymesJoan B. Broderick*, Benjamin R. Duffus, Kaitlin S. Duschene, and Eric M. ShepardView Author InformationDepartment of Chemistry Biochemistry, Montana State University, Bozeman, 59717, United States*E-mail: [email protected]Cite this: Chem. Rev. 2014, 114, 8, 4229–4317Publication Date (Web):January 29, 2014Publication History Received25 August 2013Published online29 January 2014Published inissue 23 April 2014https://doi.org/10.1021/cr4004709Copyright © 2014 American Chemical SocietyRIGHTS & PERMISSIONSACS Editors’ ChoiceArticle Views21468Altmetric-Citations467LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated by Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence for given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InReddit (28 MB) Get e-AlertsSUBJECTS:Iron,Peptides proteins,Monomers,Metal clusters,Cluster chemistry e-Alerts

Language: Английский

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Photoexcited CRY2 Interacts with CIB1 to Regulate Transcription and Floral Initiation in Arabidopsis

Science, Journal Year: 2008, Volume and Issue: 322(5907), P. 1535 - 1539

Published: Nov. 7, 2008

Cryptochromes (CRY) are photolyase-like blue-light receptors that mediate light responses in plants and animals. How plant cryptochromes act response to blue is not well understood. We report here the identification characterization of Arabidopsis CIB1 (cryptochrome-interacting basic-helix-loop-helix) protein. interacts with CRY2 (cryptochrome 2) a light-specific manner yeast cells, it acts together additional CIB1-related proteins promote CRY2-dependent floral initiation. binds G box (CACGTG) vitro higher affinity than its interaction other E-box elements (CANNTG). However, stimulates FT messenger RNA expression, chromatin DNA gene possesses various except box. propose light-dependent cryptochrome(s) represents an early photoreceptor signaling mechanism plants.

Language: Английский

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The Radical-Pair Mechanism of Magnetoreception

Annual Review of Biophysics, Journal Year: 2016, Volume and Issue: 45(1), P. 299 - 344

Published: May 24, 2016

Although it has been known for almost half a century that migratory birds can detect the direction of Earth's magnetic field, primary sensory mechanism behind this remarkable feat is still unclear. The leading hypothesis centers on radical pairs—magnetically sensitive chemical intermediates formed by photoexcitation cryptochrome proteins in retina. Our aim here to explain and physical aspects radical-pair biologists biological physicists. In doing so, we review current state knowledge magnetoreception mechanisms. We dare hope tutorial will stimulate new interdisciplinary experimental theoretical work shed much-needed additional light fascinating problem biology.

Language: Английский

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Molecular Mechanisms of Mammalian Global Genome Nucleotide Excision Repair

Chemical Reviews, Journal Year: 2005, Volume and Issue: 106(2), P. 253 - 276

Published: Dec. 27, 2005

ADVERTISEMENT RETURN TO ISSUEPREVarticleNEXTMolecular Mechanisms of Mammalian Global Genome Nucleotide Excision RepairLudovic C. J. GilletLudovic GilletInstitute for Molecular Cancer Research, University Zürich, Switzerland, and Department Pharmacological Sciences, SUNY Stony Brook, New York 11794-3400 More by Ludovic Gillet Orlando D. Schärer*Orlando SchärerInstitute Corresponding author: Tel. (631) 632-7545. Fax 632-7546. E-mail: [email protected].More SchärerCite this: Chem. Rev. 2006, 106, 2, 253–276Publication Date (Web):December 27, 2005Publication History Published online27 December 2005Published inissue 1 February 2006https://pubs.acs.org/doi/10.1021/cr040483fhttps://doi.org/10.1021/cr040483fresearch-articleACS PublicationsCopyright © 2006 American Chemical SocietyRequest reuse permissionsArticle Views4403Altmetric-Citations479LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Adducts,Aromatic compounds,Genetics,Irradiation,Lesions,Nucleic acid structure,Peptides proteins Get e-Alerts

Language: Английский

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Magnetic orientation and magnetoreception in birds and other animals

Journal of Comparative Physiology A, Journal Year: 2005, Volume and Issue: 191(8), P. 675 - 693

Published: May 11, 2005

Language: Английский

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