Efficient Bacteria Killing by Cu2WS4 Nanocrystals with Enzyme-like Properties and Bacteria-Binding Ability DOI
Jingyang Shan, Xiao Li,

Kaili Yang

et al.

ACS Nano, Journal Year: 2019, Volume and Issue: 13(12), P. 13797 - 13808

Published: Nov. 7, 2019

Antibacterial agents with high antibacterial efficiency and bacteria-binding capability are highly desirable. Herein, we describe the successful preparation of Cu2WS4 nanocrystals (CWS NCs) excellent activity. CWS NCs small size (∼20 nm) achieve more than 5 log (>99.999%) inactivation both Staphylococcus aureus (Gram-positive) Escherichia coli (Gram-negative) at low concentration (<2 μg mL-1) or without ambient light, which is much better most reported nanomaterials (including Ag, TiO2, etc.) even widely used antibiotics (vancomycin daptomycin). mechanism study showed that have enzyme-like (oxidase peroxidase) properties selective ability, greatly facilitate production reactive oxygen species to kill bacteria. Animal experiments further indicated can effectively treat wounds infected methicillin-resistant (MRSA). This work demonstrates potential as effective nanozymes for treatment bacterial infection.

Language: Английский

Use of Synchrotron Radiation-Analytical Techniques To Reveal Chemical Origin of Silver-Nanoparticle Cytotoxicity DOI
Liming Wang, Tianlu Zhang,

Panyun Li

et al.

ACS Nano, Journal Year: 2015, Volume and Issue: 9(6), P. 6532 - 6547

Published: May 21, 2015

To predict potential medical value or toxicity of nanoparticles (NPs), it is necessary to understand the chemical transformation during intracellular processes NPs. However, a grand challenge capture high-resolution image metallic NPs in single cell and information on Here, by integrating synchrotron radiation-beam transmission X-ray microscopy (SR-TXM) SR-X-ray absorption near edge structure (SR-XANES) spectroscopy, we successfully 3D distribution silver (AgNPs) inside human monocyte (THP-1), associated with silver. The results reveal that cytotoxicity AgNPs largely due particulate from elemental (Ag0)n, Ag+ ions Ag–O–, then Ag–S– species. These provide direct evidence long-lasting debate whether nanoscale ionic form dominates nanoparticles. Further, present approach provides an integrated strategy capable exploring origins

Language: Английский

Citations

269
Antibacterial activity and mechanism of Ag–ZnO nanocomposite on S. aureus and GFP-expressing antibiotic resistant E. coli DOI
Ishita Matai, Abhay Sachdev, Poornima Dubey

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2013, Volume and Issue: 115, P. 359 - 367

Published: Dec. 19, 2013

Language: Английский

Citations

268
Ag-Based nanocomposites: synthesis and applications in catalysis DOI
Guangfu Liao, Jiasheng Fang, Qing Li

et al.

Nanoscale, Journal Year: 2019, Volume and Issue: 11(15), P. 7062 - 7096

Published: Jan. 1, 2019

Supported Ag nanocomposites and bimetallic Ag-based with various morphologies compositions engineered for representative catalytic applications are reviewed.

Language: Английский

Citations

263
A Gold/Silver Hybrid Nanoparticle for Treatment and Photoacoustic Imaging of Bacterial Infection DOI
Taeho Kim, Qiangzhe Zhang, Jin Li

et al.

ACS Nano, Journal Year: 2018, Volume and Issue: 12(6), P. 5615 - 5625

Published: May 10, 2018

Ag+ ions are a well-known antibacterial agent, and Ag nanoparticles act as reservoir of these for targeted therapy bacterial infections. However, there no tools to effectively trigger monitor the release from nanoparticles. Photoacoustic (PA) imaging is an emerging noninvasive tool, gold nanorods (AuNRs) excellent contrast agent PA imaging. In this work, we developed Au/Ag hybrid by coating AuNRs with silver (Ag), which decreased their photoacoustic signal. The as-prepared, Ag-coated Au (Au/AgNRs) stable under ambient conditions, but addition ferricyanide solution (1 mM) results in oxidative etching shell. simultaneously recovered released, signal offers monitoring localized ions. released exhibit strong bactericidal efficacy similar equivalent free (AgNO3), killed >99.99% both (Gram-positive) methicillin-resistant Staphylococcus aureus (MRSA, 32 μM equivalent) (Gram-negative) Escherichia coli (8 equivalent). theranostic potential was demonstrated pilot vivo study. Mice were inoculated MRSA Au/AgNRs subcutaneously implanted followed etching. There 730% increase (p < 0.01) pre- post-etching, counts infected tissues treated group reduced 1000-fold (log CFU/g = 4.15 vs 7.75) versus untreated control; treatment confirmed histology. We further showed that could after stimulation reactive oxygen species including hydrogen peroxide peroxynitrite. These useful

Language: Английский

Citations

258
Efficient Bacteria Killing by Cu2WS4 Nanocrystals with Enzyme-like Properties and Bacteria-Binding Ability DOI
Jingyang Shan, Xiao Li,

Kaili Yang

et al.

ACS Nano, Journal Year: 2019, Volume and Issue: 13(12), P. 13797 - 13808

Published: Nov. 7, 2019

Antibacterial agents with high antibacterial efficiency and bacteria-binding capability are highly desirable. Herein, we describe the successful preparation of Cu2WS4 nanocrystals (CWS NCs) excellent activity. CWS NCs small size (∼20 nm) achieve more than 5 log (>99.999%) inactivation both Staphylococcus aureus (Gram-positive) Escherichia coli (Gram-negative) at low concentration (<2 μg mL-1) or without ambient light, which is much better most reported nanomaterials (including Ag, TiO2, etc.) even widely used antibiotics (vancomycin daptomycin). mechanism study showed that have enzyme-like (oxidase peroxidase) properties selective ability, greatly facilitate production reactive oxygen species to kill bacteria. Animal experiments further indicated can effectively treat wounds infected methicillin-resistant (MRSA). This work demonstrates potential as effective nanozymes for treatment bacterial infection.

Language: Английский

Citations

233