ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(5), P. 3916 - 3968
Published: Jan. 23, 2024
Dynamic
variations
in
the
concentration
and
abnormal
distribution
of
endogenous
biomarkers
are
strongly
associated
with
multiple
physiological
pathological
states.
Therefore,
it
is
crucial
to
design
imaging
systems
capable
real-time
detection
dynamic
changes
for
accurate
diagnosis
effective
treatment
diseases.
Recently,
ratiometric
has
emerged
as
a
widely
used
technique
sensing
due
its
advantage
circumventing
limitations
inherent
conventional
intensity-dependent
signal
readout
methods
while
also
providing
built-in
self-calibration
correction.
Here,
recent
progress
probes
their
applications
outlined.
Ratiometric
classified
according
mechanisms,
photoacoustic
imaging,
optical
including
photoluminescence
self-luminescence
magnetic
resonance
dual-modal
discussed.
The
such
pH,
reactive
oxygen
species
(ROS),
nitrogen
(RNS),
glutathione
(GSH),
gas
molecules,
enzymes,
metal
ions,
hypoxia
discussed
detail.
Additionally,
this
Review
presents
an
overview
challenges
faced
field
along
future
research
directions.
Advanced Functional Materials,
Journal Year:
2020,
Volume and Issue:
30(22)
Published: March 17, 2020
Abstract
Microbial
colonization
on
material
surfaces
is
ubiquitous.
Biofilms
derived
from
surface‐colonized
microbes
pose
serious
problems
to
the
society
both
an
economical
perspective
and
a
health
concern.
Incorporation
of
antimicrobial
nanocompounds
within
or
surface
materials,
by
coatings,
prevent
microbial
adhesion
kill
microorganisms
after
their
attachment
biofilms,
represents
important
strategy
in
increasingly
challenging
field.
Over
last
decade,
many
studies
have
been
devoted
preparing
meta‐based
nanomaterials
that
possess
antibacterial,
antiviral,
antifungal
activities
combat
pathogen‐related
diseases.
Herein,
overview
state‐of‐the‐art
nanosized
metal‐based
compounds
provided,
including
metal
oxide
nanoparticles
as
well
transition
nanosheets.
The
mechanism
these
nanostructures
biomedical
applications
such
catheters,
implants,
medical
delivery
systems,
tissue
engineering,
dentistry
are
discussed.
Their
properties
potential
caveats
cytotoxicity,
diminishing
efficacy,
induction
resistance
materials
incorporating
reviewed
provide
backdrop
for
future
research.
Advanced Materials,
Journal Year:
2018,
Volume and Issue:
31(6)
Published: Dec. 17, 2018
Abstract
Photoacoustic
(PA)
imaging
as
a
fast‐developing
technique
has
great
potential
in
biomedical
and
clinical
applications.
It
is
noninvasive
modality
that
depends
on
the
light‐absorption
coefficient
of
imaged
tissue
injected
PA‐imaging
contrast
agents.
Furthermore,
PA
provides
superb
contrast,
super
spatial
resolution,
high
penetrability
sensitivity
to
functional
characteristics
by
detecting
acoustic
wave
construct
images.
In
recent
years,
series
agents
are
developed
improve
performance
Here,
progress
their
applications
outlined.
classified
according
components
function,
gold
nanocrystals,
gold‐nanocrystal
assembly,
transition‐metal
chalcogenides/MXene‐based
nanomaterials,
carbon‐based
other
inorganic
agents,
small
organic
molecules,
semiconducting
polymer
nanoparticles,
nonlinear
discussed.
The
biosensors
(in
sensing
metal
ions,
pH,
enzymes,
temperature,
hypoxia,
reactive
oxygen
species,
nitrogen
species)
bioimaging
(lymph
nodes,
vasculature,
tumors,
brain
tissue)
discussed
detail.
Finally,
an
outlook
future
research
investigation
significance
presented.
Angewandte Chemie International Edition,
Journal Year:
2020,
Volume and Issue:
59(29), P. 11717 - 11731
Published: March 5, 2020
Optical
imaging
plays
a
crucial
role
in
biomedicine.
However,
due
to
strong
light
scattering
and
autofluorescence
biological
tissue
between
650-900
nm,
conventional
optical
often
has
poor
signal-to-background
ratio
shallow
penetration
depth,
which
limits
its
ability
deep-tissue
vivo
imaging.
Second
near-infrared
fluorescence,
chemiluminescence,
photoacoustic
modalities
mitigate
these
issues
by
their
respective
advantages
of
minimized
scattering,
eliminated
external
excitation,
ultrasound
detection.
To
enable
disease
detection,
activatable
molecular
probes
(AMPs)
with
the
change
second
or
signals
response
biomarker
have
been
developed.
This
Minireview
summarizes
design
strategies,
sensing
mechanisms,
applications
AMPs.
The
potential
challenges
perspectives
AMPs
are
also
discussed.
ACS Nano,
Journal Year:
2020,
Volume and Issue:
14(3), P. 2585 - 2627
Published: Feb. 7, 2020
Nanotheranostics
is
one
of
the
biggest
scientific
breakthroughs
in
nanomedicine.
Most
currently
available
diagnosis
and
therapies
are
invasive,
time-consuming,
associated
with
severe
toxic
side
effects.
Nanotheranostics,
on
other
hand,
has
potential
to
bridge
this
gap
by
harnessing
capabilities
nanotechnology
nanomaterials
for
combined
therapeutics
diagnostics
markedly
enhanced
efficacy.
However,
nanomaterial
applications
nanotheranostics
still
its
infancy.
This
due
fact
that
each
disease
a
particular
microenvironment
well-defined
characteristics,
which
promotes
deeper
selection
criteria
meet
needs.
In
review,
we
have
outlined
how
designed
tailored
cancer
diseases
such
as
neurodegenerative,
autoimmune
(particularly
rheumatoid
arthritis),
cardiovascular
diseases.
The
penetrability
retention
biological
system,
therapeutic
strategy
used,
imaging
mode
selected
some
aspects
discussed
disease.
specific
properties
terms
feasibility,
physicochemical
challenges,
progress
clinical
trials,
toxicity,
their
future
application
translational
medicine
addressed.
Our
review
meticulously
critically
examines
various
nanomaterials,
including
graphene,
across
several
diseases,
offering
broader
perspective
emerging
field.
Advanced Materials,
Journal Year:
2019,
Volume and Issue:
32(3)
Published: March 29, 2019
Abstract
On
the
basis
of
Jablonski
diagram,
photophysical
properties
optical
agents
are
highly
associated
with
biomedical
function
and
efficacy.
Herein,
focus
is
on
organic/polymer
recent
progress
in
main
strategies
for
regulating
their
to
achieve
superior
cancer
diagnosis/phototheranostics
applications
highlighted.
Both
approaches
nanoengineering
molecular
design,
which
can
lead
optimized
effectiveness
required
function,
discussed.
Advanced Science,
Journal Year:
2020,
Volume and Issue:
7(10)
Published: April 6, 2020
The
development
of
antimicrobial
drug
resistance
among
pathogenic
bacteria
and
fungi
is
one
the
most
significant
health
issues
21st
century.
Recently,
advances
in
nanotechnology
have
led
to
nanomaterials,
particularly
metals
that
exhibit
properties.
These
metal
nanomaterials
emerged
as
promising
alternatives
traditional
therapies.
In
this
review,
a
broad
overview
their
synthesis,
properties,
interactions
with
micro-organisms
first
provided.
Secondly,
range
demonstrate
passive
properties
are
outlined
in-depth
analysis
comparison
stimuli-responsive
provided,
which
represent
next
generation
microbiocidal
nanomaterials.
stimulus
applied
activate
such
includes
light
(including
photocatalytic
photothermal)
magnetic
fields,
can
induce
hyperthermia
kinetically
driven
activation.
Broadly,
review
aims
summarize
currently
available
research
provide
future
scope
for
nanomaterial-based
technologies,
those
be
activated
through
externally
stimuli.
ACS Nano,
Journal Year:
2021,
Volume and Issue:
15(4), P. 6147 - 6191
Published: March 19, 2021
Janus
nanoparticles
(JNPs)
refer
to
the
integration
of
two
or
more
chemically
discrepant
composites
into
one
structure
system.
Studies
JNPs
have
been
significant
interest
due
their
interesting
characteristics
stemming
from
asymmetric
structures,
which
can
integrate
different
functional
properties
and
perform
synergetic
functions
simultaneously.
Herein,
we
present
recent
progress
particles,
comprehensively
detailing
fabrication
strategies
applications.
First,
classification
is
divided
three
blocks,
consisting
polymeric
composites,
inorganic
hybrid
polymeric/inorganic
composites.
Then,
are
alternately
summarized,
examining
self-assembly
strategy,
phase
separation
seed-mediated
polymerization,
microfluidic
preparation
nucleation
growth
methods,
masking
methods.
Finally,
various
intriguing
applications
presented,
including
solid
surfactants
agents,
micro/nanomotors,
biomedical
such
as
biosensing,
controlled
drug
delivery,
bioimaging,
cancer
therapy,
combined
theranostics.
Furthermore,
challenges
future
works
in
this
field
provided.
ACS Nano,
Journal Year:
2020,
Volume and Issue:
14(8), P. 9408 - 9422
Published: Aug. 10, 2020
Photoacoustic
(PA)
imaging
is
an
emerging
modality
whereby
pulsed
laser
illumination
generates
pressure
transients
that
are
detectable
using
conventional
ultrasound.
Plasmonic
nanoparticles
such
as
gold
nanorods
and
nanostars
often
used
PA
contrast
agents.
The
thermoelastic
expansion
model
best
describes
the
response
from
plasmonic
nanoparticles:
Light
absorption
causes
a
small
increase
in
temperature
leading
to
expansion.
conversion
of
optical
energy
into
waves
(po)
dependent
on
several
features:
(i)
coefficient
(μa),
(ii)
thermal
(β),
(iii)
specific
heat
capacity
(Cp)
absorbing
material,
(iv)
speed
sound
medium
(c),
(v)
fluence
(F).
Controlling
geometry,
composition,
coatings,
solvents
around
nanostructures
can
help
tune
these
variables
generate
optimum
signal.
not
limited
structures
holds
true
for
all
molecules.
Here,
we
focus
ways
engineer
enhance
nanoparticles.
Advanced Science,
Journal Year:
2022,
Volume and Issue:
9(27)
Published: July 25, 2022
Due
to
the
abuse
of
antibiotics
and
emergence
multidrug
resistant
microorganisms,
medical
devices,
related
biomaterials
are
at
high
risk
microbial
infection
during
use,
placing
a
heavy
burden
on
patients
healthcare
systems.
Metal-phenolic
networks
(MPNs),
an
emerging
organic-inorganic
hybrid
network
system
developed
gradually
in
recent
years,
have
exhibited
excellent
multifunctional
properties
such
as
anti-inflammatory,
antioxidant,
antibacterial
by
making
use
coordination
between
phenolic
ligands
metal
ions.
Further,
MPNs
received
widespread
attention
antimicrobial
infections
due
their
facile
synthesis
process,
biocompatibility,
brought
about
polyphenols
In
this
review,
different
categories
based
(nanoparticles,
coatings,
capsules,
hydrogels)
fabrication
strategies
summarized,
research
advances
applications
biomedical
fields
(e.g.,
skin
repair,
bone
regeneration,
etc.)
highlighted.
