Cellular uptake of nanoparticles: journey inside the cell

Chemical Society Reviews, Journal Year: 2017, Volume and Issue: 46(14), P. 4218 - 4244

Published: Jan. 1, 2017

Nanoscale materials are increasingly found in consumer goods, electronics, and pharmaceuticals. While these particles interact with the body myriad ways, their beneficial and/or deleterious effects ultimately arise from interactions at cellular subcellular level. Nanoparticles (NPs) can modulate cell fate, induce or prevent mutations, initiate cell-cell communication, structure a manner dictated largely by phenomena nano-bio interface. Recent advances chemical synthesis have yielded new nanoscale precisely defined biochemical features, emerging analytical techniques shed light on nuanced context-dependent within cells. In this review, we provide an objective comprehensive account of our current understanding uptake NPs underlying parameters controlling nano-cellular interactions, along available to follow track processes.

Language: Английский

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Silver Nanoparticles: Synthesis and Application for Nanomedicine

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(4), P. 865 - 865

Published: Feb. 17, 2019

Over the past few decades, metal nanoparticles less than 100 nm in diameter have made a substantial impact across diverse biomedical applications, such as diagnostic and medical devices, for personalized healthcare practice. In particular, silver (AgNPs) great potential broad range of applications antimicrobial agents, device coatings, drug-delivery carriers, imaging probes, optoelectronic platforms, since they discrete physical optical properties biochemical functionality tailored by size- shape-controlled AgNPs. this review, we aimed to present major routes synthesis AgNPs, including physical, chemical, biological processes, along with physiochemical characteristics We also discuss underlying intricate molecular mechanisms behind their plasmonic on mono/bimetallic structures, cellular/microbial cytotoxicity, property. Lastly, conclude review summary current AgNPs nanoscience nanomedicine future perspectives these areas.

Language: Английский

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Silver nanoparticles: Synthesis, medical applications and biosafety

Theranostics, Journal Year: 2020, Volume and Issue: 10(20), P. 8996 - 9031

Published: Jan. 1, 2020

Silver nanoparticles (AgNPs) have been one of the most attractive nanomaterials in biomedicine due to their unique physicochemical properties. In this paper, we review state-of-the-art advances AgNPs synthesis methods, medical applications and biosafety AgNPs. The methods include physical, chemical biological routes. are mainly used for antimicrobial anticancer therapy, also applied promotion wound repair bone healing, or as vaccine adjuvant, anti-diabetic agent biosensors. This summarizes action mechanisms AgNPs, which involve release silver ions (Ag+), generation reactive oxygen species (ROS), destruction membrane structure. Despite these therapeutic benefits, safety problems such potential toxicity on cells, tissue, organs should be paid enough attention. Besides, briefly introduce a new type Ag particles smaller than Ångstrom (Å, 1 Å = 0.1 nm) (AgÅPs), exhibit better activity lower compared with Finally, conclude current challenges point out future development direction

Language: Английский

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Nanotechnology: A New Opportunity in Plant Sciences

Trends in Plant Science, Journal Year: 2016, Volume and Issue: 21(8), P. 699 - 712

Published: April 30, 2016

Language: Английский

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Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Advanced Functional Materials, Journal Year: 2020, Volume and Issue: 30(22)

Published: March 17, 2020

Abstract Microbial colonization on material surfaces is ubiquitous. Biofilms derived from surface‐colonized microbes pose serious problems to the society both an economical perspective and a health concern. Incorporation of antimicrobial nanocompounds within or surface materials, by coatings, prevent microbial adhesion kill microorganisms after their attachment biofilms, represents important strategy in increasingly challenging field. Over last decade, many studies have been devoted preparing meta‐based nanomaterials that possess antibacterial, antiviral, antifungal activities combat pathogen‐related diseases. Herein, overview state‐of‐the‐art nanosized metal‐based compounds provided, including metal oxide nanoparticles as well transition nanosheets. The mechanism these nanostructures biomedical applications such catheters, implants, medical delivery systems, tissue engineering, dentistry are discussed. Their properties potential caveats cytotoxicity, diminishing efficacy, induction resistance materials incorporating reviewed provide backdrop for future research.

Language: Английский

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The Crown and the Scepter: Roles of the Protein Corona in Nanomedicine

Advanced Materials, Journal Year: 2018, Volume and Issue: 31(45)

Published: Dec. 27, 2018

Engineering nanomaterials are increasingly considered promising and powerful biomedical tools or devices for imaging, drug delivery, cancer therapies, but few have been tested in clinical trials. This wide gap between bench discoveries application is mainly due to the limited understanding of biological identity nanomaterials. When they exposed human body, nanoparticles inevitably interact with bodily fluids thereby adsorb hundreds biomolecules. A "biomolecular corona" forms on surface confers a new NPs, which determines following events: cellular uptake, immune response, biodistribution, clearance, toxicity. deep thorough effects triggered by protein corona vivo will speed up their translation clinic. To date, nearly all studies attempted characterize components coronas depending different physiochemical properties NPs. Herein, recent advances reviewed order better understand impact nanoparticle-corona nanomedicine applications. The development formation pharmacokinetics nanomedicines also highlighted. Finally, challenges opportunities toward future applications discussed.

Language: Английский

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Precise nanomedicine for intelligent therapy of cancer

Science China Chemistry, Journal Year: 2018, Volume and Issue: 61(12), P. 1503 - 1552

Published: Dec. 1, 2018

Language: Английский

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A Review of Silver Nanoparticles: Research Trends, Global Consumption, Synthesis, Properties, and Future Challenges

Journal of the Chinese Chemical Society, Journal Year: 2017, Volume and Issue: 64(7), P. 732 - 756

Published: June 8, 2017

Silver nanoparticles (AgNPs) are intensively investigated for their superior physical, chemical, and biological properties. A proper knowledge of these properties is essential to maximizing the potential applications AgNPs in several areas while minimizing risks humans environment. This paper aims critically review from perspectives research trends, global consumption, synthesis, properties, future challenges. Generally, can be synthesized using three methods, namely biological, related works as well numerous advantages disadvantages presented this review. In addition, potentially explored various applications. Future challenges on (AgNP) release into environment, scaling up production, review, suggest that topics available promote a safer more efficient use nanoparticles. Studies Malaysia have increased since Malaysian government officially established directorate nanotechnology development. calls set policies starting production utilization effects industries

Language: Английский

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Beyond PM2.5: The role of ultrafine particles on adverse health effects of air pollution

Biochimica et Biophysica Acta (BBA) - General Subjects, Journal Year: 2016, Volume and Issue: 1860(12), P. 2844 - 2855

Published: March 16, 2016

Language: Английский

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Silver Nanoparticles: Bactericidal and Mechanistic Approach against Drug Resistant Pathogens

Microorganisms, Journal Year: 2023, Volume and Issue: 11(2), P. 369 - 369

Published: Feb. 1, 2023

This review highlights the different modes of synthesizing silver nanoparticles (AgNPs) from their elemental state to particle format and mechanism action against multidrug-resistant biofilm-forming bacterial pathogens. Various studies have demonstrated that AgNPs cause oxidative stress, protein dysfunction, membrane disruption, DNA damage in bacteria, ultimately leading death. also been found alter adhesion cells prevent biofilm formation. The benefits using medicine are, some extent, counter-weighted by toxic effect on humans environment. In this review, we compiled recent demonstrating antibacterial activity AgNPs, are discussing known mechanisms Ongoing clinical trials involving briefly presented. A particular focus is placed interaction with biofilms, which a significant pathogenicity determinant. brief overview use other medical applications (e.g., diagnostics, promotion wound healing) non-medical sectors Finally, current drawbacks limitations discussed, perspectives for improved future functionalized

Language: Английский

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