Multi-Mimic Activities of Co3O4 Nanopolyhedrons and Application in Regulating the Content of Intracellular Hydrogen Peroxide/Oxygen DOI

Yu Zhu,

Jun Yan, Jing Liu

et al.

ACS Applied Nano Materials, Journal Year: 2022, Volume and Issue: 5(10), P. 15102 - 15114

Published: Oct. 10, 2022

Herein, Co3O4 nanopolyhedrons with multi-mimics of peroxidase (POD)-, oxidase (OXD)-, catalase (CAT)-, and glutathione (GPx)-like activities were developed utilized in the application regulating level cellular oxygen hydrogen peroxide combined polydopamine (PDA). It was found that multi-mimic can be controlled by pH OXD- POD-like best when 4 but became weak under weakly acidic or neutral conditions. Meanwhile, CAT-like activity conditions, GPx-like better conditions than According to high especially at tumor cell microenvironment, catalytically transform H2O2 into O2 without interferences from other mimic activities. After coating PDA, Co3O4@PDA good biocompatibility dispersion also catalyzed produce microenvironment efficiency. The corresponding fluorescent probes used monitor process, main mechanisms investigated through fluorescence spectra confocal microscopy. This work not only verifies multi-enzyme properties provides a nanomaterial for regulation content cells utilizing enzyme property nanomaterial. is considered concentration variation active small molecules regulated nanoenzymes may provide some basis cancer diagnosis treatment.

Language: Английский

Chiral Iron Oxide Supraparticles Enable Enantiomer‐Dependent Tumor‐Targeted Magnetic Resonance Imaging DOI
Chen Li, Jing Zhao, Xiaoqing Gao

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(49)

Published: Sept. 18, 2023

The chemical, physical and biological effects of chiral nanomaterials have inspired general interest demonstrated important advantages in fundamental science. Here, iron oxide supraparticles (Fe3 O4 SPs) modified by penicillamine (Pen) molecules with g-factor ≈2 × 10-3 at 415 nm are fabricated, these SPs act as high-quality magnetic resonance imaging (MRI) contrast agents. Therein, the transverse relaxation efficiency T2 -MRI results Fe3 a r2 relaxivity 157.39 ± 2.34 mM-1 ·S-1 for D-Fe3 136.21 1.26 L-Fe3 due to enhanced electronic transition dipole moment compared SPs. vivo MRI show that exhibit two-fold lower ratio than SPs, which enhances targeted enrichment tumor tissue, such prostate cancer, melanoma brain glioma tumors. Notably, it is found 7.7-fold higher affinity cell surface receptor cluster-of-differentiation 47 (CD47) These findings uncover highly effective agent targeting broad tumors, thus accelerating practical application deepening understanding chirality non-biological environments.

Language: Английский

Citations

18
Chirality-Dependent Copper–Diphenylalanine Assemblies with Tough Layered Structure and Enhanced Catalytic Performance DOI
Gong Zhang, Yaoyu Liang, Yuefei Wang

et al.

ACS Nano, Journal Year: 2022, Volume and Issue: 16(4), P. 6866 - 6877

Published: March 23, 2022

Chiral regulation to prepare functional materials has aroused considerable interest in recent years. However, little is known on the effect of chirality ligands metal-organic coordination assembly process. We report self-assembly diphenylalanine peptide (Phe-Phe, FF), core fragment Aβ protein, with metal copper ion (Cu2+) into assemblies chirality-encoded structures and properties. The chirality-dependent metal-dipeptide assembles different morphologies supramolecular were obtained by facile changing FF chirality. Single-crystal results indicate that (L)-FF coordinated Cu2+ a cross-chain structure five-coordinated style, while racemates (L+D)-FF crystallized an (L)-Cu2+-(D)-Cu2+ alternated four-coordinating structure, enabling higher mechanical catalytic performance. Young's modulus (L+D)-FF-Cu as high 34.36 GPa, which 2.45 times than (L)-FF-Cu. Furthermore, both them follow characteristic enzyme kinetics show activity natural laccase at same mass concentration. Specifically, calculated efficiency (kcat/KM) 1.14 (L)-FF-Cu, shows significantly enhanced stability reusability compared reveal highly could be constructed encoding molecular building blocks.

Language: Английский

Citations

28
Magneto-Optics Effects: New Trends and Future Prospects for Technological Developments DOI Creative Commons
Conrad Rizal, Hiromasa Shimizu, J. R. Mejía-Salazar

et al.

Magnetochemistry, Journal Year: 2022, Volume and Issue: 8(9), P. 94 - 94

Published: Aug. 24, 2022

Magneto-optics (MO) is an effervescent research field, with a wide range of potential industrial applications including sensing, theranostics, pharmaceutics, magnetometry, and spectroscopy, among others. This review discusses the historical development, from discovery MO effects up to most recent application trends. In addition consolidated fields magnetoplasmonic sensing modulation optical signals, we describe novel materials, phenomena, applications. We also identified emerging field all-dielectric magnetophotonics, which hold promise overcome dissipation metallic inclusions in plasmonic nanostructures. Moreover, some challenges, such as need merge magneto-chiroptical microfluidics technology, for chiral enantioseparation drugs pharmaceutical industry. Other are discussed light achievements available literature.

Language: Английский

Citations

27
Enantiomeric NIR‐II Emitting Rare‐Earth‐Doped Ag2Se Nanoparticles with Differentiated In Vivo Imaging Efficiencies DOI
Qi Ding, Jing Zhao, Hongyu Zhang

et al.

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(45)

Published: Sept. 20, 2022

Here, chiral second near-infrared (NIR-II) emitting rare-earth doped silver selenide nanoparticles (R- or S-Ag2 Se:Nd/Yd/Er NPs) were fabricated, exhibiting circular dichroism peak at 850 nm and fluorescence 1550 nm, with 145.7-fold enhanced intensity compared to the reported Ag2 Se NPs. Compared NPs, imaging efficiency of R-Ag2 NPs in living cells was significantly improved due a higher cellular uptake rate 927.7-fold affinity. Furthermore, reached tumor 2-fold faster than S type vivo. We discover that chirality leads differences affinity between cluster differentiation 44 (CD44) onto surface murine mammary carcinoma cell cause different vivo efficiency. These results reveal have high photoluminescence reflecting wide applications biomedical diagnosis.

Language: Английский

Citations

24
Fast Antioxidation Kinetics of Glutathione Intracellularly Monitored by a Dual‐Wire Nanosensor DOI Open Access

Yuting Jiao,

Yi‐Ran Kang,

Ming‐Yong Wen

et al.

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(51)

Published: Nov. 1, 2023

Abstract The glutathione (GSH) system is one of the most powerful intracellular antioxidant systems for elimination reactive oxygen species (ROS) and maintaining cellular redox homeostasis. However, rapid kinetics information (at millisecond to second level) during dynamic antioxidation process GSH remains unclear. As such, we specifically developed a novel dual‐wire nanosensor (DWNS) that can selectively synchronously measure levels ROS with high temporal resolution, applied it monitor transient generation as well in individual cancer cells. These measurements revealed peroxidase (GPx) rapidly initiated against burst sub‐second time scale, but short‐lived, ending after few seconds, while some are still present This study expected open new perspectives understanding studying imbalance‐related physiological.

Language: Английский

Citations

15
Chiral Magnetic Oxide Nanomaterials: Magnetism Meets Chirality DOI
Xing Liu, Yanli Du, Stefanos Mourdikoudis

et al.

Advanced Optical Materials, Journal Year: 2023, Volume and Issue: 11(18)

Published: April 3, 2023

Abstract Chiral magnetic oxide nanomaterials (CMONs), which combine the beneficial effects of chirality and magnetism in a single unit, have found applications biomedical, optical, electronic devices as well catalysis sensing. This is largely due to simultaneous presence properties, catalytic activity, biocompatibility optical or magneto‐optical effects, are circular polarization magnetization dependent. review summarizes key findings derived from recent research works on synthesis, CMONs. The three main approaches synthesis property tuning CMONs, namely, post‐functionalization, situ approach, assembly with soft templates, discussed. A summary some future prospects CMONs respect their synthetic routes, origin, also provided.

Language: Английский

Citations

14
Sensitive and Selective Dual‐Mode Responses to Reactive Oxygen Species by Chiral Manganese Dioxide Nanoparticles for Antiaging Skin DOI

Aihua Qu,

Qiwen Chen, Maozhong Sun

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(5)

Published: Sept. 28, 2023

Excessive accumulation of reactive oxygen species (ROS) can lead to oxidative stress and damage, which is one the important factors for aging age-related diseases. Therefore, real-time monitoring moderate elimination ROS extremely important. In this study, a ROS-responsive circular dichroic (CD) at 553 nm magnetic resonance imaging (MRI) dual-signals chiral manganese oxide (MnO

Language: Английский

Citations

14
Upconversion-based chiral nanoprobe for highly selective dual-mode sensing and bioimaging of hydrogen sulfide in vitro and in vivo DOI Creative Commons
Yang Lü,

Xu Zhao,

Dongmei Yan

et al.

Light Science & Applications, Journal Year: 2024, Volume and Issue: 13(1)

Published: Aug. 1, 2024

Abstract Chiral assemblies have become one of the most active research areas due to their versatility, playing an increasingly important role in bio-detection, imaging and therapy. In this work, chiral UCNPs/Cu x OS@ZIF nanoprobes are prepared by encapsulating upconversion nanoparticles (UCNPs) Cu OS (NPs) into zeolitic imidazolate framework-8 (ZIF-8). The novel excited-state energy distribution-modulated nanostructure (NaYbF 4 @NaYF : Yb, Er) is selected as fluorescence source donor for highly efficient resonance transfer (FRET). NP employed acceptor quench luminescence (UCL) provide circular dichroism (CD) signal. Utilizing natural adsorption sorting advantages ZIF-8, designed nanoprobe can isolate influence other common disruptors, thus achieve ultra-sensitive selective UCL/CD dual-mode quantification H 2 S aqueous solution living cells. Notably, also capable vivo intra-tumoral tracking. Our work highlights multifunctional properties nanocomposites sensing opens a new vision idea preparation application nanomaterials biomedical biological analysis.

Language: Английский

Citations

4
Dual Functionality of Cobalt Oxide Nanoparticles: Exploring Their Potential as Antimicrobial and Anticancer Agents DOI
Ikhazuagbe H. Ifijen,

Emmanuel Faderin,

C. O. OKAFOR

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Language: Английский

Citations

0
Chiral Inorganic Nanomaterial‐Based Diagnosis and Treatments for Neurodegenerative Diseases DOI Open Access

Jingqi Dong,

Liguang Xu,

Aihua Qu

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 9, 2025

Chiral nanomaterials are widely investigated over recent decades due to their biocompatibility and unique chiral effects. These key properties have significantly promoted the rapid development of in bioengineering medicine. In this review, basic principles constructing along with latest progress research comprehensively summarized. Then, application for diagnosis neurodegenerative diseases (NDDs) is systematically described. addition, significant potential broad prospects treatment NDDs highlighted from several aspects, including disaggregation neurofibrils, scavenging reactive oxygen species, regulation microbial-gut-brain axis, elimination senescent cells, promotion directed differentiation neural stem cells. Finally, a perspective challenges future provided.

Language: Английский

Citations

0