Bio‐inspired Structure‐editing Fluorescent Hydrogel Actuators for Environment‐interactive Information Encryption

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(23)

Published: March 16, 2023

Abstract Many living organisms have the superb structure‐editing capacity for better adaptation in dynamic environments over course of their life cycle. However, it's still challenging to replicate such natural into artificial hydrogel actuating systems enhancing environment‐interactive functions. Herein, we learn from metamorphosis development glowing octopus construct proof‐of‐concept fluorescent actuators with life‐like by developing a universal stepwise inside‐out growth strategy. These could perform origami‐like 3D shape deformation and also enable postnatal new structures adapt additional states different visual information delivery using environment keys (e.g., temperature, pH). This study opens previously unidentified‐avenues bio‐inspired actuators/robotics extends potential uses encryption.

Language: Английский

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Model-based modular hydrogel design

Nature Reviews Bioengineering, Journal Year: 2024, Volume and Issue: 2(7), P. 575 - 587

Published: March 26, 2024

Language: Английский

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Mechanism exploration of intestinal mucus penetration of nano-Se: regulated by polysaccharides with different functional groups and molecular weights

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 524 - 536

Published: Jan. 21, 2025

Language: Английский

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Mussel-inspired cross-linking mechanisms enhance gelation and adhesion of multifunctional mucin-derived hydrogels

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(8)

Published: Feb. 19, 2025

Mucus supports human health by hydrating, lubricating, and preventing infection of wet epithelial surfaces. The beneficial material properties bioactivity mucus stem from glycoproteins called mucins, motivating the development mucin-derived hydrogels for wound dressings antifouling coatings. However, these applications require robust gelation adhesion to a wide range substrates. Inspired chemical cross-linking water-tolerant marine mussel adhesive structures, we use catechol–thiol bonding drive native mucin proteins synthetic mucin-inspired polymers, forming soft, that can be coated onto diverse dynamics systematically tuned varying hydrogel composition, polymer architecture, thiol availability, with timescales adjustable seconds hours, values elastic modulus, failure stress, debonding work spanning orders magnitude. We demonstrate functionality gels in two applications: as tissue adhesives, using porcine skin proxy skin, bioactive surface coatings prevent bacterial colonization. results highlight potential versatile platform engineering multifunctional glycoprotein repair antimicrobial engineering.

Language: Английский

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Functional microneedles for wearable electronics

Smart Medicine, Journal Year: 2023, Volume and Issue: 2(1)

Published: Feb. 1, 2023

Abstract With an ideal comfort level, sensitivity, reliability, and user‐friendliness, wearable sensors are making great contributions to daily health care, nursing early disease discovery, body monitoring. Some imparted with hierarchical uneven microstructures, such as microneedle structures, which not only facilitate the access multiple bio‐analysts in human but also improve abilities detect feeble signals. In this paper, we present promising applications latest progress of functional microneedles sensors. We begin by discussing roles sensing units, including how signals captured, converted, transmitted. introduce microneedle‐like structures power depend on triboelectric or piezoelectric effects, etc. Finally, summarize cutting‐edge microneedle‐based biophysical signal monitoring biochemical analyte detection, provide critical thinking their future perspectives.

Language: Английский

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Mucosa‐Inspired Electro‐Responsive Lubricating Supramolecular‐Covalent Hydrogel

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(46)

Published: Sept. 24, 2023

Enabling the living capability of secreting liquids dynamically triggered by external stimuli while maintaining bulk frame is a significant challenge for mucosa-inspired hydrogels. A electro-responsive hydrogel developed in this study using synergy between silk fibroin supramolecular non-covalent networks and covalent polyacrylamide polyvinyl alcohol polymer networks. The formed supramolecular-covalent exhibits partial gel-sol transition upon application an electric field, liquid layer on surface near cathode used to mimic mucus-secreting regulate lubrication. lubricating process can operate under safe voltage good reversibility. It also universal strategy construct introducing network into network. This offers promising method designing soft actuators or robots that lubrication strategy.

Language: Английский

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Diversification of Acrylamide Polymers via Direct Transamidation of Unactivated Tertiary Amides

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(2), P. 1627 - 1634

Published: Jan. 8, 2024

Postpolymerization modification offers a versatile strategy for synthesizing complex macromolecules, yet modifying acrylamide polymers like poly(N,N-dimethylacrylamide) (PDMA) is notoriously challenging due to the inherent stability and low reactivity of amide bonds. In this study, we unveil novel approach direct transamidation PDMA, leveraging recent advances in unactivated tertiary substrates. By exploiting photoiniferter polymerization, extended ultrahigh-molecular-weight (UHMW) showcasing unprecedented postpolymerization synthetic exceeding 106 g/mol. We also designed copolymers comprising both moderately reactive N-methyl-N-phenyl amides, along with less reactive, fully alkyl-substituted N,N-dimethyl amides PDMA. This disparate enabled sequential, chemoselective by initially targeting more pendant aryl nucleophilic aromatic amines, second, transamidating untouched moieties aliphatic yielding uniquely diversified copolymer. work not only broadens scope strategies pioneering but provides robust platform design intricate particularly realm UHMW polymers.

Language: Английский

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Dual-responsive nanocarriers for efficient cytosolic protein delivery and CRISPR-Cas9 gene therapy of inflammatory skin disorders

Science Advances, Journal Year: 2024, Volume and Issue: 10(16)

Published: April 17, 2024

Developing protein drugs that can target intracellular sites remains a challenge due to their inadequate membrane permeability. Efficient carriers for cytosolic delivery are required protein-based drugs, cancer vaccines, and CRISPR-Cas9 gene therapies. Here, we report screening process identify highly efficient materials from library of dual-functionalized polymers bearing both boronate lipoic acid moieties. Both ligands were found be crucial binding, endosomal escape, release. Polymers with higher grafting ratios exhibit remarkable efficacies in including enzymes, monoclonal antibodies, Cas9 ribonucleoprotein while preserving activity. Optimal polymer successfully delivered targeting

Language: Английский

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β-Triketones as Reactive Handles for Polymer Diversification via Dynamic Catalyst-Free Diketoenamine Click Chemistry

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(23), P. 16257 - 16267

Published: June 4, 2024

The spontaneous condensation of amines with β-triketones (TK), forming β,β′-diketoenamines (DKE) and releasing water as the sole byproduct, exhibits many hallmarks "click" reactions. Such characteristics render TKs a highly advantageous platform for efficient polymer diversification, even in biological contexts. Leveraging reversible addition–fragmentation chain transfer (RAFT) photoiniferter polymerization novel TK-containing vinylic monomers, we synthesized polymers containing pendent excellent control molecular weights, excess 106 g mol–1. Under mild, catalyst-free conditions, poly(β-triketone methacrylate) could be modified diverse scope plethora functional groups. high efficiency this functionalization approach was further emphasized when grafting-to poly(ethylene glycol)-amine resulting bottlebrushes weights reaching 2.0 × 107 Critically, while formed DKE linkages are stable under ambient they undergo catalyst-free, dynamic transamination at elevated temperatures, paving way associative covalent adaptable networks. Overall, introduce triketone moieties into methacrylate acrylamide polymers, establishing postpolymerization modification technique that facilitates ligation permissible conditions.

Language: Английский

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Hydrogel Derived from Decellularized Porcine Small Intestinal Submucosa as a Physical Shielding Repaired the Gut Epithelial Barrier of Murine Ulcerative Colitis

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(45)

Published: June 3, 2024

Abstract Ulcerative colitis (UC) is associated with the shedding of gut mucus. Decellularized porcine small intestinal submucosa (SIS‐ECM) contains numerous active forms extracellular matrix as well growth factors. Herein, a mucus‐mimetic hydrogel (MAG) designed barrier therapy by integrating SIS‐ECM hyaluronic acid and epigallocatechin‐3‐gallate. MAG not only presented viscoelastic behaviors G' 4000 Pa but also good thixotropy. Moreover, physical shielding effective to hinder E. coli invasion. Besides, repairing effect on injured Caco‐2 cells MAG. When biomimetic mucus rectally administrated mouse, it alleviated effectively symptoms improved colonic shorting. expression IL‐1β, IL‐6, TNF‐α at laminae propria substantially inhibited epitheliums are rearranged, tight junction proteins (ZO‐1, Occludin‐1, Claudin‐5) between them greatly upregulated after treatment. Meanwhile, secretion goblets repaired The mechanism mucosa barriers promoting proliferation differentiation stem cells. Collectively, might be promising strategy for UC.

Language: Английский

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