Angewandte Chemie,
Journal Year:
2023,
Volume and Issue:
136(11)
Published: Dec. 12, 2023
Abstract
Organic
fluorophores
are
indispensable
tools
in
cells,
tissue
and
vivo
imaging,
have
enabled
much
progress
the
wide
range
of
biological
biomedical
fields.
However,
many
available
dyes
suffer
from
insufficient
performances,
such
as
short
absorption
emission
wavelength,
low
brightness,
poor
stability,
small
Stokes
shift,
unsuitable
permeability,
restricting
their
application
advanced
imaging
technology
complex
imaging.
Over
past
two
decades,
efforts
been
made
to
improve
these
performances
fluorophores.
Starting
with
luminescence
principle
fluorophores,
this
review
clarifies
mechanisms
performance
for
traditional
a
certain
extent,
systematically
summarizes
modified
approaches
optimizing
properties,
highlights
typical
applications
improved
sensing,
indicates
existing
problems
challenges
area.
This
not
only
proves
significance
improving
but
also
provide
theoretical
guidance
development
high‐performance
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(12)
Published: Jan. 11, 2023
Phototheranostics
have
emerged
and
flourished
as
a
promising
pattern
for
cancer
theranostics
owing
to
their
precise
photoinduced
diagnosis
therapeutic
meet
the
demands
of
precision
medicine.
The
information
effect
are
directly
determined
by
fluorescence
imaging
ability
photothermal
conversion
efficiency
(PCE)
phototheranostic
agents.
Hence,
how
balance
competitive
radiative
nonradiative
processes
agents
is
key
factor
evaluate
effect.
Herein,
molecules
named
ICRs
with
high
photostaibility
rationally
designed,
exhibiting
emission
in
second
near-infrared
window
(NIR-II,
1000-1700
nm)
PCE,
which
related
strong
donor-acceptor
(D-A)
interaction
reorganization
energy
Noteworthily,
ICR-Qu
stronger
D-A
large-sized
conjugated
unit
encapsulated
nanoparticles
exhibits
PCE
(81.1%).
In
addition,
ICR-QuNPs
used
(FLI),
photoacoustic
(PAI),
(PTI)
guide
deep-tissue
photonic
hyperthermia,
achieving
removal
inhibition
breast
cancer.
Furthermore,
combined
α-PD-1,
show
huge
potential
be
facile
efficient
tool
photo-immunotherapy.
More
importantly,
this
study
not
only
reports
an
"all-in-one"
polymethine-based
agent,
but
also
sheds
light
on
exploration
versatile
organic
future
practical
applications.
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(22), P. 12013 - 12022
Published: May 22, 2023
The
shortwave
infrared
(SWIR)
spectral
region
beyond
1200
nm
offers
optimal
tissue
penetration
depth
and
has
broad
potential
in
diagnosis,
therapy,
surgery.
Here,
we
devised
a
novel
class
of
fluorochromic
scaffold,
i.e.,
tetra-benzannulated
xanthenoid
(EC7).
EC7
absorbs/emits
maximally
at
1204/1290
CH2Cl2
exhibits
an
unparalleled
molar
absorptivity
3.91
×
105
cm–1
M–1
high
transparency
to
light
400–900
nm.
It
also
exhibited
resistance
toward
both
photobleaching
symmetry
breaking
due
its
unique
structural
rigidity.
is
feasible
for
vivo
bioimaging
particularly
suitable
couple
with
the
shorter-wavelength
analogues
high-contrast
multiplexing.
High-contrast
dual-channel
intraoperative
imaging
hepatobiliary
system
three-channel
intestine,
stomach,
vasculature
were
showcased.
benchmark
fluorochrome
facile
biomedical
exploitation
SWIR
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
63(11)
Published: Dec. 12, 2023
Abstract
Organic
fluorophores
are
indispensable
tools
in
cells,
tissue
and
vivo
imaging,
have
enabled
much
progress
the
wide
range
of
biological
biomedical
fields.
However,
many
available
dyes
suffer
from
insufficient
performances,
such
as
short
absorption
emission
wavelength,
low
brightness,
poor
stability,
small
Stokes
shift,
unsuitable
permeability,
restricting
their
application
advanced
imaging
technology
complex
imaging.
Over
past
two
decades,
efforts
been
made
to
improve
these
performances
fluorophores.
Starting
with
luminescence
principle
fluorophores,
this
review
clarifies
mechanisms
performance
for
traditional
a
certain
extent,
systematically
summarizes
modified
approaches
optimizing
properties,
highlights
typical
applications
improved
sensing,
indicates
existing
problems
challenges
area.
This
not
only
proves
significance
improving
but
also
provide
theoretical
guidance
development
high‐performance
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
52(18), P. 6344 - 6358
Published: Jan. 1, 2023
This
review
analyzes
strategies
to
convert
key
fluorophores
into
red/NIR
emitting
derivatives,
with
typical
examples
of
how
such
can
be
used
develop
molecular
probes
for
biological
analytes,
along
sensing
features.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(8)
Published: Jan. 18, 2023
Abstract
Fast
and
selective
fluorescence
imaging
for
a
biomarker
to
related‐disease
diagnosis
remains
significant
challenge
due
complex
physical
environment.
Human
carboxylesterase
(CE)
is
expected
be
potential
of
hepatocellular
carcinoma
(HCC)
improve
the
accuracy
diagnosis.
However,
existing
probes
CE
has
slow
response
rate
low
selectivity.
Herein,
amide
group
selected
as
CE‐responsive
sites
based
on
“substrate‐hydrolysis
enzymatic
reaction”
approach.
From
series
off–on
with
leave
groups
in
unit,
probe
J
screened
optimal
combination
rapid
high
selectivity
toward
CE.
requires
only
150
s
reach
maximum
at
676
nm
presence
free
from
interference
other
esterase.
Computational
docking
simulations
indicate
shortest
distance
between
active
site
.
Cell
vivo
present
that
can
turn
liver
cancer
cells
tumor
region
precisely.
Importantly,
allowed
specifically
image
orthotopic
rather
than
metastatic
distinguish
human
primary
tissue
adjacent
ones.
This
study
provides
new
tool
detection
promotes
advancements
accurate
HCC
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: March 22, 2024
Abstract
Long-wavelength,
near-infrared
small-molecule
dyes
are
attractive
in
biophotonics.
Conventionally,
they
rely
on
expanded
aromatic
structures
for
redshift,
which
comes
at
the
cost
of
application
performance
such
as
photostability,
cell
permeability,
and
functionality.
Here,
we
report
a
ground-state
antiaromatic
strategy
showcase
concise
synthesis
14
cationic
aminofluorene
with
mini
(molecular
weights:
299–504
Da)
distinct
spectra
covering
700–1600
nm.
Aminofluorene
cell-permeable
achieve
rapid
renal
clearance
via
simple
44
Da
carboxylation.
This
accelerates
optical
diagnostics
injury
by
50
min
compared
to
existing
macromolecular
approaches.
We
develop
compact
molecular
sensing
platform
vivo
intracellular
sensing,
demonstrate
versatile
applications
these
multispectral
fluorescence
optoacoustic
imaging.
find
that
aromaticity
reversal
upon
electronic
excitation,
indicated
magnetic
descriptors,
not
only
reduces
energy
bandgap
but
also
induces
strong
vibronic
coupling,
resulting
ultrafast
excited-state
dynamics
unparalleled
photostability.
These
results
support
argument
antiaromaticity
useful
design
rule
dye
development,
enabling
performances
essential
modern
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(11)
Published: Jan. 16, 2024
Abstract
Achieving
photothermal
therapy
(PTT)
at
ultralow
laser
power
density
is
crucial
for
minimizing
photo‐damage
and
allowing
higher
maximum
permissible
skin
exposure.
However,
this
requires
agents
to
possess
not
just
superior
conversion
efficiency
(PCE),
but
also
exceptional
near‐infrared
(NIR)
absorptivity.
J
‐aggregates,
exhibit
a
significant
redshift
narrower
absorption
peak
with
extinction
coefficient.
Nevertheless,
achieving
predictable
‐aggregates
through
molecular
design
remains
challenge.
In
study,
we
successfully
induced
desirable
J‐
aggregation
(λ
abs
max
:
968
nm,
ϵ:
2.96×10
5
M
−1
cm
,
λ
em
972
Φ
FL
6.2
%)
by
tuning
electrostatic
interactions
between
π‐conjugated
planes
manipulating
surface
potential
of
aromatic
ring‐fused
aza‐BODIPY
dyes.
Notably,
controlling
the
preparation
method
encapsulating
dyes
into
F‐127
polymer,
were
able
selectively
generate
H
‐/
respectively.
Furthermore,
exhibited
two
controllable
morphologies:
nanospheres
nanowires.
Importantly,
shortwave‐infrared
‐aggregated
nanoparticles
impressive
PCE
72.9
%
effectively
destroyed
cancer
cells
mice‐tumors
an
0.27
W
−2
(915
nm).
This
phototherapeutic
nano‐platform,
which
generates
behavior,
can
controllably
form
/
H‐
aggregates
selectable
aggregate
morphology,
valuable
paradigm
developing
tumor‐treatment
density.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(18)
Published: March 2, 2024
Abstract
Photoacoustic
imaging
(PAI)‐guided
photothermal
therapy
(PTT)
in
the
second
near‐infrared
(NIR‐II,
1000–1700
nm)
window
has
been
attracting
attention
as
a
promising
cancer
theranostic
platform.
Here,
it
is
reported
that
π‐extended
porphyrins
fused
with
one
or
two
nanographene
units
(NGP‐1
and
NGP‐2)
can
serve
new
class
of
NIR‐responsive
organic
agents,
displaying
absorption
extending
to
≈1000
≈1400
nm
NIR‐I
NIR‐II
windows,
respectively.
NGP‐1
NGP‐2
are
dispersed
water
through
encapsulation
into
self‐assembled
nanoparticles
(NPs),
achieving
high
conversion
efficiency
60%
69%,
respectively,
under
808
1064
laser
irradiation.
Moreover,
NIR‐II‐active
NGP‐2‐NPs
demonstrated
photoacoustic
responses,
along
photostability
biocompatibility,
enabling
PAI
efficient
PTT
vivo.
