Activatable Janus Nanoparticles for Precise NIR‐II Bioimaging and Synergistic Cancer Therapy DOI

Jiasheng Bao,

Ruiqi Liu,

Zhouyu Yu

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(27)

Published: Feb. 25, 2024

Abstract Despite multifunctional theranostics hold vast potential in deep tissue bioimaging and tumor therapy, activatable nanomedicine with integration of precise diagnosis effective treatment is usually achieved at the cost complicated synthesis chemistries. Here, a facile way to design bioresponsive Ag 2 S‐Ag Janus probes coated by polyethylene glycol (PEG) (denoted as AAP) showed, active second near‐infrared window (NIR‐II, 1000–1700 nm). In microenvironment, part can yield hydroxyl radicals (·OH) consuming H O for high‐efficiency chemodynamic therapy (CDT), while S has impressive photothermal (PTT). The synergistic benefits from parts further boosted CDT effect AAP high conversion efficiency up 56.8%. Moreover, multiple lines evidence supported that extremely faint fluorescence be significantly activated overexpressed levels , showing bright NIR‐II emission ≈1270 nm over 5.6 × 10 3 ‐fold increase signal intensity. are easily imaging tumor‐specific identification, effectively ablate tissues inhibition rate 96.2%. This study expects probe will open new route achieve window.

Language: Английский

Doping Engineering to Modulate Lattice and Electronic Structure for Enhanced Piezocatalytic Therapy and Ferroptosis DOI Open Access
Boshi Tian, Ruixue Tian, Shaohua Liu

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(38)

Published: July 12, 2023

Piezocatalytic therapy, which generates reactive oxygen species (ROS) under mechanical force, has garnered extensive attention for its use in cancer therapy owing to deep tissue penetration depth and less O2 -dependence. However, the piezocatalytic therapeutic efficiency is limited poor piezoresponse, low separation of electron-hole pairs, complicated tumor microenvironment (TME). Herein, a biodegradable, porous Mn-doped ZnO (Mn-ZnO) nanocluster with enhanced piezoelectric effect constructed via doping engineering. Mn-doping not only induces lattice distortion increase polarization but also creates rich vacancies (OV ) suppressing recombination leading high-efficiency generation ROS ultrasound irradiation. Moreover, shows TME-responsive multienzyme-mimicking activity glutathione (GSH) depletion ability mixed valence Mn (II/III), further aggravating oxidative stress. Density functional theory calculations show that can improve performance enzyme Mn-ZnO due presence OV . Benefiting from boosting GSH ability, significantly accelerate accumulation lipid peroxide inactivate peroxidase 4 (GPX4) induce ferroptosis. The work may provide new guidance exploring novel sonosensitizers therapy.

Language: Английский

Citations

85
Self‐Destructive Copper Carriers Induce Pyroptosis and Cuproptosis for Efficient Tumor Immunotherapy Against Dormant and Recurrent Tumors DOI Open Access

Luying Qiao,

Guo‐Qing Zhu, Tengfei Jiang

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(8)

Published: Oct. 11, 2023

Abstract Activating the strong immune system is a key initiative to counteract dormant tumors and prevent recurrence. Herein, self‐destructive multienzymatically active copper‐quinone‐GOx nanoparticles (abbreviated as CQG NPs) have been designed induce harmonious balanced pyroptosis cuproptosis using “Tai Chi mindset” awaken response for suppressing recurrent tumors. This cleverly material can disrupt antioxidant defense mechanism of tumor cells by inhibiting nuclear factor‐erythroid 2‐related factor 2 (NRF2)‐quinone oxidoreductase 1 (NQO1) signaling pathway. Furthermore, combined with its excellent multienzyme activity, it activates NOD‐like receptor protein 3 (NLRP3)‐mediated pyroptosis. Meanwhile, be triggered copper ions released from disintegration NPs sensitivity cancer enhanced through depletion endogenous chelators via Michael addition reaction between glutathione (GSH) quinone ligand, oxygen production catalase‐like reaction, starvation‐induced glucose deficiency. More importantly, NPs‐induced promote immunosuppressive microenvironment (TME) remodeling, enhance infiltration into tumor, activate robust systemic immunity. Collectively, this study provides new strategy resist dormancy, recurrence, improve clinical prognosis

Language: Английский

Citations

83
Deep Insight of Design, Mechanism, and Cancer Theranostic Strategy of Nanozymes DOI Creative Commons
Lu Yang, Shuming Dong, Shili Gai

et al.

Nano-Micro Letters, Journal Year: 2023, Volume and Issue: 16(1)

Published: Nov. 21, 2023

Since the discovery of enzyme-like activity Fe

Language: Английский

Citations

65
Defect Engineering in Nanocatalysts: From Design and Synthesis to Applications DOI
Pir Muhammad, Amir Zada, Jamshaid Rashid

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(29)

Published: Feb. 13, 2024

Abstract Defect engineering is an emerging technology for tailoring nanomaterials' characteristics and catalytic performance in various applications. Recently, defect‐engineered nanoparticles have emerged as highly researched materials applications because of their exceptional redox reaction capabilities physicochemical optical properties. The properties nanomaterials can be readily adjusted by controlling the nature concentration defects within nanoparticles, avoiding need intricate design strategies. This review investigates defect nanocatalysts, including design, fabrication, Initially, categories strategies nanomaterial impacts on nanocatalysts' electronic surface properties, activity, selectivity, stability are summarized. Then, processes uses, gas sensing, hydrogen (H 2 ) evolutions, water splitting, reductions carbon dioxide (CO nitrogen to value‐aided products, pollutant degradation, biomedical (oncotherapy, antibacterial wound healing, biomolecular sensing) discussed. Finally, limitations prospective paths allowing logical optimization nanocatalytic long‐term efficient also examined. comprehensive gives unique insights into current state nanocatalysts inspires future research exploiting shortcomings improve customize performance.

Language: Английский

Citations

49
A Mild Hyperthermia Hollow Carbon Nanozyme as Pyroptosis Inducer for Boosted Antitumor Immunity DOI
Na Tao, Lei Jiao, Huihuang Li

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(22), P. 22844 - 22858

Published: Nov. 9, 2023

The immune checkpoint blockade (ICB) antibody immunotherapy has demonstrated clinical benefits for multiple cancers. However, the efficacy of in tumors is suppressed by deficient tumor immunogenicity and immunosuppressive microenvironments. Pyroptosis, a form programmed cell death, can release antigens, activate effective immunogenicity, improve efficiency ICB, but efficient pyroptosis treatment currently limited. Herein, we show mild hyperthermia-enhanced pyroptosis-mediated based on hollow carbon nanozyme, which specifically amplify oxidative stress-triggered synchronously magnify anticancer responses microenvironment. sphere modified with iron copper atoms (HCS-FeCu) enzyme-mimicking activities been engineered to induce via radical oxygen species (ROS)-Tom20-Bax-Caspase 3-gasdermin E (GSDME) signaling pathway under light activation. Both vitro vivo antineoplastic results confirm superiority HCS-FeCu nanozyme-induced pyroptosis. Moreover, photothermal-activated combining anti-PD-1 enhance antitumor immunotherapy. Theoretical calculations further indicate that photothermal stimulation generates high-energy electrons enhances interaction between surface adsorbed oxygen, facilitating molecular activation, improves ROS production efficiency. This work presents an approach effectively transforms immunologically "cold" into "hot" ones, significant implications

Language: Английский

Citations

47
Catalyzing Generation and Stabilization of Oxygen Vacancies on CeO2−x Nanorods by Pt Nanoclusters as Nanozymes for Catalytic Therapy DOI Creative Commons
Jiankang Zhang, Yu Yang,

Fengmin Qin

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(31)

Published: Sept. 14, 2023

Abstract Although CeO 2 nanomaterials have been widely explored as nanozymes for catalytic therapy, they still suffer from relatively low activities. Herein, the catalyzing generation and stabilization of oxygen vacancies on nanorods by Pt nanoclusters via H gas reduction under mild temperature (350 °C) to obtain Pt/CeO 2− x , which can serve a highly efficient nanozyme cancer is reported. The deposited atomic layer deposition technique not only catalyst generate through hydrogen spillover effect, but also stabilize generated vacancies. Meanwhile, provide anchoring sites forming strong metal‐support interactions thus preventing their agglomerations. Importantly, reduced at 350 °C (Pt/CeO ‐350R) exhibits excellent enzyme‐mimicking activity reactive species (e.g., ·OH) compared other control samples, including temperatures, achieving performance tumor‐specific therapy efficiently eliminate cells in vitro ablate tumors vivo. ‐350R originates good activities vacancy‐rich nanoclusters.

Language: Английский

Citations

43
Injectable Conductive Hydrogel with Self‐Healing, Motion Monitoring, and Bacteria Theranostics for Bioelectronic Wound Dressing DOI

Mengyao Shan,

Xin Chen,

Xiaoyang Zhang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(11)

Published: Jan. 13, 2024

Abstract Wounds at joints are difficult to treat and tend recover more slowly due the frequent motions. When using traditional hydrogel dressings, they easy crack undergo bacterial infection, match monitor irregular wounds. Integrating multiple functions within a dressing achieve intelligent wound monitoring healing remains significant challenge. In this research, multifunctional is developed based on polysaccharide biopolymer, poly(vinyl alcohol), hydroxylated graphene through dynamic borate ester bonding supramolecular interaction. The prepared not only exhibits rapid self‐healing (within 60 s), injectable, conductive motion properties, but also realizes in situ sensing killing functions. It shows excellent sensitivity 15 min) ability via changes of electrical signals photothermal therapy, avoiding emergence drug‐resistant bacteria. vivo experiments prove that can promote effectively. addition, it displays great electromechanical performance real‐time prevent re‐tearing human joints. injectable pH‐responsive with good biocompatibility demonstrates considerable potential as bioelectronic for detection, treatment, management, infected joint

Language: Английский

Citations

41
Glutathione Induced In situ Synthesis of Cu Single‐Atom Nanozymes with Anaerobic Glycolysis Metabolism Interference for Boosting Cuproptosis DOI
Wenying Zhang, Meifang Wang, Bin Liu

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(18)

Published: Feb. 23, 2024

Abstract Single‐atom nanozyme (SAzyme) has sparked increasing interest for catalytic antitumor treatment due to their more tunable and diverse active sites than natural metalloenzymes in complex physiological conditions. However, it is usually a hard task precisely conduct catalysis at tumor after intravenous injection of those SAzyme with high reactivity. Moreover, the explorations SAzymes anticancer application are still its infancy need be developed. Herein, an situ synthesis strategy Cu was constructed convert adsorbed copper ions into isolated atoms anchored by oxygen (Cu−O 2 /Cu−O 4 ) via GSH‐responsive deformability supports. Our results suggest that activation process could further facilitate dissociation consumption glutathione, thereby leading deposition cytoplasm triggering cuproptosis. peroxidase‐like activity enabled intracellular reactive species production, resulting specifically disturbance metabolism pathway. Meanwhile, exposed glucose transporter (GLUT) inhibitor phloretin (Ph) can block glycose uptake boost cuproptosis efficacy. Overall, this effectively diminished off‐target effects SACs‐induced therapies introduced promising paradigm advancing cuproptosis‐associated therapies.

Language: Английский

Citations

36
Recent advances in metal–organic frameworks for stimuli-responsive drug delivery DOI
Fei Xing, Jiawei Xu, Yuxi Zhou

et al.

Nanoscale, Journal Year: 2024, Volume and Issue: 16(9), P. 4434 - 4483

Published: Jan. 1, 2024

Metal-organic frameworks have become promising stimuli-responsive agents to release the loaded therapeutic in target site achieve more precise drug delivery due their high loading, excellent biocompatibility, and stimuli-responsiveness.

Language: Английский

Citations

30
A Copper/Ferrous‐Engineering Redox Homeostasis Disruptor for Cuproptosis/Ferroptosis Co‐Activated Nanocatalytic Therapy in Liver Cancer DOI
Xiaoling Zhang, Jiuxin Zhu,

Sihao Wang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(37)

Published: April 25, 2024

Abstract Cuproptosis and ferroptosis hold great promise for overcoming apoptotic resistance in liver cancer based on their unique metal‐driven cell death modalities. However, insufficient intracellular copper iron concentration, complicated tumor microenvironment (TME), unclear cross‐regulatory mechanisms between cuproptosis ferroptosis, severely restrict the therapeutic performance. Herein, copper‐doped hollow Prussian blue (CHP) nanozymes are rationally designed loading photosensitizer indocyanine green (ICG) O 2 ‐saturated perfluorohexane (PFH), denoted as ‐PFH@CHPI nanoparticles, to induce ferroptosis. In response specific TME, CHP can synergistically catalyze Fenton reactions consume endogenous glutathione, leading accumulation of reactive oxygen species. Upon near‐infrared irradiation, ‐PFH@CHPI‐enabled photothermal effect simultaneously accelerate catalytic trigger release photodynamic therapy promote oxidative stress. Notably, be effectively activated through Cu + ‐mediated dihydrolipoamide S‐acetyltransferase aggregation Fe–S cluster protein loss. Concurrently, tilt redox balance is favorable lipid peroxidation glutathione peroxidase 4 inactivation, resulting an augmented effect. Mechanistically, stress‐boosted jointly disrupt mitochondrial metabolism, which turn exacerbates stress, thus realizing a mutually enhanced This work may provide new guidance utilizing copper/ferrous‐engineering cuproptosis/ferroptosis synergetic therapy.

Language: Английский

Citations

29