Porous Fe/Cu Nanoreactor with Dual Insurance Design for Precision Chemotherapy and Chemodynamic Therapy DOI
Xianyu Zhu,

Lingli Gao,

Yanbo Zheng

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Abstract Poor prognosis and chemotherapy response stem from difficulties in precise targeting the lack of effective synergistic treatments. Nanozymes show promising potential tumor chemodynamic therapy (CDT) by catalyzing hydrogen peroxide (H₂O₂) decomposition glutathione depletion microenvironment (TME). However, integrating with CDT remains challenging. In this study, a porous Fe/Cu bimetallic nanozyme carrier (FeCuNPs) is developed for co‐loading humanized 3F8 anti‐GD2 disialoganglioside antibody (3F8) novel pyridazinone‐based chemotherapeutic agent (IMB), forming nanoreactor (3F8@FeCuNPs@IMB) targeted CDT. The responds specifically to acidic TME as primary insurance, allowing controlled release IMB at site. coating on surface acts secondary minimizing drug leakage during delivery process ensuring chemotherapy. Furthermore, FeCuNPs act peroxidase‐like (POD) oxidase‐like (GSHOX) enzymes, hydroxyl radical (•OH) generation depleting excess GSH, enhancing results vitro vivo indicate that dual insurance designed 3F8@FeCuNPs@IMB offers prospect targeted, precise, combination against melanoma.

Language: Английский

A strategy of “adding fuel to the flames” enables a self-accelerating cycle of ferroptosis-cuproptosis for potent antitumor therapy DOI
Lin Huang,

Jiaoyang Zhu,

Guochao Wu

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 311, P. 122701 - 122701

Published: July 6, 2024

Language: Английский

Citations

22
Targeting cuproptosis for cancer therapy: mechanistic insights and clinical perspectives DOI Creative Commons
Chenliang Zhang, Tingting Huang, Liping Li

et al.

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: Aug. 16, 2024

Cuproptosis is a newly identified form of cell death induced by excessive copper (Cu) accumulation within cells. Mechanistically, cuproptosis results from Cu-induced aggregation dihydrolipoamide S-acetyltransferase, correlated with the mitochondrial tricarboxylic acid cycle and loss iron–sulfur cluster proteins, ultimately resulting in proteotoxic stress triggering death. Recently, has garnered significant interest tumor research due to its potential as crucial therapeutic strategy against cancer. In this review, we summarized cellular molecular mechanisms relationship other types Additionally, reviewed current drugs or strategies available induce cells, including Cu ionophores, small compounds, nanomedicine. Furthermore, targeted metabolism specific regulatory genes cancer therapy enhance sensitivity cuproptosis. Finally, discussed feasibility targeting overcome chemotherapy immunotherapy resistance suggested future directions. This study that could open new avenues for developing therapy.

Language: Английский

Citations

22
Copper-Based Biomaterials for Anti-Tumor Therapy: Recent Advances and Perspectives DOI
Shufang Zhang, Shuping Peng

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

2
Advances in cuproptosis harnessing copper-based nanomaterials for cancer therapy DOI
Yuanying Yang, Chen Dong, Xuehua Ma

et al.

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review discusses the recent developments in copper-based nanomaterials that utilize copper-induced cell death, categorized by materials systems, while highlighting limitations of current cuproptosis related nanomaterials.

Language: Английский

Citations

2
Redox-manipulating nanocarriers for anticancer drug delivery: a systematic review DOI Creative Commons
Xuan Meng,

Yongli Shen,

Huanyu Zhao

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 28, 2024

Language: Английский

Citations

17
Cuproptosis in cancer: biological implications and therapeutic opportunities DOI Creative Commons
Liping Li,

Houfeng Zhou,

Chenliang Zhang

et al.

Cellular & Molecular Biology Letters, Journal Year: 2024, Volume and Issue: 29(1)

Published: June 25, 2024

Abstract Cuproptosis, a newly identified copper (Cu)-dependent form of cell death, stands out due to its distinct mechanism that sets it apart from other known death pathways. The molecular underpinnings cuproptosis involve the binding Cu lipoylated enzymes in tricarboxylic acid cycle. This interaction triggers enzyme aggregation and proteotoxic stress, culminating death. specific has yet be fully elucidated. recognized sparked numerous investigations into role tumorigenesis cancer therapy. In this review, we summarized current knowledge on metabolism link cancer. Furthermore, delineated mechanisms roles cuproptosis-related genes Finally, offered comprehensive discussion most recent advancements ionophores nanoparticle delivery systems utilize as cutting-edge strategy for treatment.

Language: Английский

Citations

11
Apoptosis‐Sensitizing Tumor Nanomedicine by Regulating Pyroptosis‐Associated Inflammatory Cell Death DOI

Fangxue Du,

Hongxin Zhao,

Yangmeihui Song

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(44)

Published: May 25, 2024

Abstract The vigorous development of cancer nanomedicine has revolutionized traditional oncology medicine, but it is also limited by the continuous mutation cunning cells, leading to apoptosis insensitivity and therapeutic disappointment. Inflammatory‐regulated cell death (RCD), especially pyroptosis‐related death, demonstrates huge potential for sensitization due its unique biochemical characteristics. aim this research present a thorough synopsis current knowledge on pyroptosis‐associated inflammatory including pyroptosis, cuproptosis, PANoptosis, synergistic function in nano therapy. Paradigm studies death‐mediated apoptosis‐sensitizing tumor nanotherapeutics are introduced detail, coordination mechanisms based nanomaterials discussed. In addition, multi‐angle analysis future prospects pyroptosis‐sensitized various emphasized further expand application scope RCD. It believed that emerging auxiliary treatments RCD will greatly promote progress nanomedicine.

Language: Английский

Citations

9
Dual‐Release Free Iron and Breakdown of Ferroptosis Defenses to Achieve Ferroptosis Cascade Storms for Potent Antitumor Therapy DOI Open Access

Wenting Xu,

Yuzhen Yang, Lijuan Liu

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Abstract Ferroptosis is a newly identified type of regulated cell death characterized by iron‐dependent lipid peroxidation. Among the main ferroptosis‐suppressing systems, dihydroorotate dehydrogenase (DHODH)‐ ubiquinone axis closely related to mitochondria and energy metabolism, implying that protects cells from oxidative stress damage via maintenance redox homeostasis. However, ferroptosis initiation requires suitable environment breakthrough in homeostatic limitations systems. Hence, nanoparticles are rationally engineered achieve efficient induction releasing dual‐release free iron disrupting Atovaquone (ATO)‐loaded hollow mesoporous etching zeolitic imidazolate framework‐67 double‐coated oxide/calcium phosphate (Fe 3 O 4 /CaP) conjugated with polyethylene glycol. The external Fe /CaP structure enhances efficiency multiple reactive oxygen species (ROS) generation promoting stress. Still, it achieves increase content unstable pools for igniting ROS storm peroxidation spark. release ATO not only affects metabolism mitochondrial respiratory chain binding complex III but also downregulates DHODH restrict ubiquinol system disrupt Therefore, design this composite nanomedicine provides an approach inducing theoretical basis clinical anti‐tumor trials.

Language: Английский

Citations

1
Nanoparticle‐Mediated Cuproptosis and Photodynamic Synergistic Strategy: A Novel Horizon for Cancer Therapy DOI Creative Commons
Junrui Zhang,

Anren Zhang,

Yibing Guo

et al.

Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(3)

Published: Jan. 27, 2025

Photodynamic therapy (PDT) is a noninvasive cancer treatment that works by using light to stimulate the production of excessive cytotoxic reactive oxygen species (ROS), which effectively eliminates tumor cells. However, therapeutic effects PDT are often limited hypoxia, prevents effective cell elimination. The (O2) consumption during can further exacerbate leading post-treatment adverse events. This review aims explore potential cuproptosis, recently discovered copper-dependent form programmed death, enhance anticancer PDT. Cuproptosis highly dependent on mitochondrial respiration, specifically tricarboxylic acid (TCA) cycle, and increase O2 ROS levels or decrease glutathione (GSH) levels, thereby improving outcomes. discusses latest research advancements in field, detailing mechanisms regulate cuproptosis It also explores how nanoparticle (NP)-based strategies be used exploit synergistic between article examines prospects activity guided nanodelivery systems, could overcome challenges associated with hypoxia treatment. combination PDT, facilitated NP-based delivery presents promising approach effectiveness therapy. concludes discussing future directions for this therapy, highlighting need investigation into optimization improve outcomes

Language: Английский

Citations

1
Mitochondria‐targeting Bimetallic Cluster Nanozymes Alleviate Neuropathic Pain Through Scavenging ROS and Reducing Inflammation DOI Open Access
Xiaolei Cheng,

Tianjiao Xia,

Min Han

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Abstract Neuropathic pain is a significant public health concern. Inflammatory mediators and reactive oxygen species (ROS) are recognized as primary contributors to perception. In this study, mitochondria‐targeted modification of bimetallic cluster nanozyme (TPP‐Au‐Ru) developed. This TPP‐Au‐Ru exhibits high affinity for the mitochondrial matrix, effectively scavenging ROS attenuating inflammatory in both vitro vivo settings. Additionally, inhibits activation MAPK NF‐κB signaling cascades protect function. Furthermore, therapeutic dose able alleviate nociceptive symptoms up 36 h with minimal biological toxicity. Therefore, sustained delivery provides an effective long‐lasting approach neuropathic pain. innovative shows promise development more efficient interventions, potentially revolutionizing management enhancing quality life affected individuals.

Language: Английский

Citations

1