European Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
27(3)
Published: Nov. 30, 2023
Abstract
Since
the
first
report
that
1,2,4,5‐tetrazines
undergo
a
bioorthogonal
reaction
with
dienophiles
in
form
of
an
inverse
electron‐demand
Diels‐Alder
reaction,
demand
for
high‐yielding
synthetic
approaches
towards
them
grew
steadily.
Despite
this
significant
interest,
tetrazines
were
predominantly
accessed
via
Pinner
synthesis
or
other
Pinner‐like
reactions,
significantly
limiting
available
substrates.
In
particular,
unsymmetrically
substituted
s‐tetrazines
selective
conjugation
to
another
species
presented
major
challenge.
To
tackle
these
challenges,
new
and
innovative
transformations
have
been
developed
widen
scope
accessible
symmetric
unsymmetric
tetrazines.
For
instance,
Ni(II),
Zn(II),
sulphur‐catalysed
reactions
between
two
nitriles
hydrazine
developed,
which
provide
access
wide
range
(un‐)symmetric
aryl
s‐tetrazines.
Also,
amidines
orthoesters
give
alkyl
substituents,
whereas
usage
CH
2
Cl
yields
valuable
H‐monosubstituted
Methods
using
thiocarbohydrazides,
terminal
fluoroolefins,
oxetane
esters,
tosyl
hydrazones
are
among
recent
additions.
Due
high
interest
tetrazine
click‐chemistry
approaches,
some
reach
beyond
we
expect
overview
routes
aid
exploration
further
applications
Ultimately,
hope
guide
chemists
chemical
biologists
accessing
functional
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(5)
Published: Sept. 13, 2023
Efficient
utilization
of
sunlight
in
photocatalysis
is
widely
recognized
as
a
promising
solution
for
addressing
the
growing
energy
demand
and
environmental
issues
resulting
from
fossil
fuel
consumption.
Recently,
there
have
been
significant
developments
various
near-infrared
(NIR)
light-harvesting
systems
artificial
photosynthesis
photocatalytic
remediation.
This
review
provides
an
overview
most
recent
advancements
NIR
light
through
creation
novel
nanostructured
materials
molecular
photosensitizers,
well
modulating
strategies
to
enhance
processes.
A
special
focus
given
emerging
two-photon
excitation
photocatalysis.
The
unique
features
limitations
different
are
critically
evaluated.
In
particular,
it
highlights
advantages
utilizing
compared
UV-visible
irradiation
one-photon
excitation.
Ongoing
challenges
potential
solutions
future
exploration
light-responsive
also
discussed.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(10), P. 6817 - 6829
Published: March 1, 2024
-Acetyl
muramic
acid
(NAM)
probes
containing
alkyne
or
azide
groups
are
commonly
used
to
investigate
aspects
of
cell
wall
synthesis
because
their
small
size
and
ability
incorporate
into
bacterial
peptidoglycan
(PG).
However,
copper-catalyzed
alkyne-azide
cycloaddition
(CuAAC)
reactions
not
compatible
with
live
cells,
strain-promoted
(SPAAC)
reaction
rates
modest
and,
therefore,
as
desirable
for
tracking
the
temporal
alterations
growth,
remodeling,
division.
Alternatively,
tetrazine-
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(9)
Published: Jan. 18, 2024
Although
the
clearance
of
senescent
cells
has
been
proven
to
slow
down
aging
process
and
promote
anti-cancer
chemotherapy,
development
senolytics
remains
challenging.
Herein,
we
report
a
senolytic
strategy
enabled
by
cell-sensitive
bioorthogonal
tetrazine
ligation.
Our
design
is
based
on
linking
dihydrotetrazine
(Tz)
galactose
(Gal)
moiety
that
serves
both
as
recognition
for
senescence-associated
β-galactosidase
caging
group
control
activity.
Gal-Tz
enables
efficient
click-release
fluorescent
hemicyanine
doxorubicin
from
trans-cyclooctene-caged
prodrug
detect
eliminate
HeLa
A549
over
non-senescent
counterparts
with
16.44
index.
Furthermore,
leverage
selective
activation
delivery
proteolysis-targeting
chimeras
(PROTACs)
senolytics.
PROTAC
TCO-ARV-771
can
be
selectively
activated
delivered
into
induce
degradation
bromodomain-containing
protein
4.
Senolytic
PROTACs
may
offer
an
way
intervention
cell
senescence
thanks
their
unique
capacity
degrade
target
proteins
in
sub-stoichiometric
catalytic
fashion.
The
results
this
study
establish
ligation
approach
viable
removal
cells.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(47)
Published: Aug. 13, 2024
Abstract
The
field
of
bioorthogonal
chemistry
has
revolutionized
our
ability
to
interrogate
and
manipulate
biological
systems
at
the
molecular
level.
However,
range
chemical
reactions
that
can
operate
efficiently
in
environments
without
interfering
with
native
cellular
machinery,
remains
limited.
In
this
context,
rapidly
growing
area
photocatalysis
offers
a
promising
avenue
for
developing
new
type
tools.
inherent
mildness,
tunability,
chemoselectivity,
external
controllability
photocatalytic
transformations
make
them
particularly
well‐suited
applications
living
systems.
This
minireview
summarizes
recent
advances
technologies,
particular
focus
on
their
potential
enable
selective
generation
designed
products
within
biologically
relevant
or
settings.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
This
article
provides
a
comprehensive
overview
of
recent
advances
in
the
development
bioorthogonally
activated
probes
for
labelling
and
precise
situ
fluorescence
imaging
both
vitro
vivo
.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(19)
Published: April 13, 2024
The
emerging
field
of
photopharmacology
is
a
promising
chemobiological
methodology
for
optical
control
drug
activities
that
could
ultimately
solve
the
off-target
toxicity
outside
disease
location
many
drugs
treatment
given
pathology.
use
photolytic
reactions
looks
very
attractive
light-activated
release
but
requires
to
develop
sensitive
red
or
near-infrared
light
excitation
better
tissue
penetration.
This
review
will
present
concepts
triplet-triplet
annihilation
upconversion-based
photolysis
and
their
recent
in
vivo
applications
light-induced
delivery
using
photoactivatable
nanoparticles.
