Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 488, P. 151072 - 151072
Published: April 8, 2024
Language: Английский
Nature Nanotechnology, Journal Year: 2024, Volume and Issue: 19(4), P. 554 - 564
Published: Jan. 15, 2024
Abstract Bladder cancer treatment via intravesical drug administration achieves reasonable survival rates but suffers from low therapeutic efficacy. To address the latter, self-propelled nanoparticles or nanobots have been proposed, taking advantage of their enhanced diffusion and mixing capabilities in urine when compared with conventional drugs passive nanoparticles. However, translational treating bladder are underexplored. Here, we tested radiolabelled mesoporous silica-based urease-powered an orthotopic mouse model cancer. In vivo ex results demonstrated nanobot accumulation at tumour site, eightfold increase revealed by positron emission tomography vivo. Label-free optical contrast based on polarization-dependent scattered light-sheet microscopy cleared bladders confirmed penetration Treating tumour-bearing mice intravesically administered radio-iodinated for radionuclide therapy resulted a size reduction about 90%, positioning as efficient delivery nanosystems therapy.
Language: Английский
Citations
57
Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(22), P. 7707 - 7736
Published: Jan. 1, 2023
This review summarizes the strategies to engineer CDT nanocatalysts based on diverse nanocarriers, especially those with intrinsic therapeutic activities.
Language: Английский
Citations
50
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: Aug. 8, 2024
Although nanocatalytic medicine has demonstrated its advantages in tumor therapy, the outcomes heavily relie on substrate concentration and metabolic pathways are still indistinct. We discover that violet phosphorus quantum dots (VPQDs) can catalyze production of reactive oxygen species (ROS) without requiring external stimuli catalytic substrates confirmed to be (O2) hydrogen peroxide (H2O2) through computational simulation experiments. Considering short O2 H2O2 at site, we utilize calcium (CaO2) supply for VPQDs construct nanoparticles together with them, named VPCaNPs. VPCaNPs induce oxidative stress cells, particularly characterized by a significant increase hydroxyl radicals superoxide radicals, which cause substantial damage structure function ultimately leading cell apoptosis. Intriguingly, provided CaO2 degrade slowly, degradation product, phosphate, as well CaO2-generated ions, promote calcification. Antitumor immune activation less metastasis also observed administrated animals. In conclusion, our study unveils anti-tumor activity catalysts generating cytotoxic ROS products calcification, providing promising strategy treating tumors.
Language: Английский
Citations
21
Nano Today, Journal Year: 2024, Volume and Issue: 55, P. 102212 - 102212
Published: Feb. 26, 2024
Language: Английский
Citations
19
Bioactive Materials, Journal Year: 2023, Volume and Issue: 32, P. 445 - 472
Published: Oct. 26, 2023
Effective tumor treatment depends on optimizing drug penetration and accumulation in tissue while minimizing systemic toxicity. Nanomedicine has emerged as a key solution that addresses the rapid clearance of free drugs, but achieving deep into solid tumors remains elusive. This review discusses various strategies to enhance penetration, including manipulation microenvironment, exploitation both external internal stimuli, pioneering nanocarrier surface engineering, development innovative tactics for active penetration. One outstanding strategy is organelle-affinitive transfer, which exploits unique properties specific cell organelles heralds potentially transformative approach transcellular transfer Rigorous models are essential evaluate efficacy these strategies. The patient-derived xenograft (PDX) model gaining traction bridge between laboratory discovery clinical application. However, journey from bench bedside nanomedicines fraught with challenges. Future efforts should prioritize deepening our understanding nanoparticle-tumor interactions, re-evaluating EPR effect, exploring novel nanoparticle transport mechanisms.
Language: Английский
Citations
40
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 510, P. 215842 - 215842
Published: April 15, 2024
Language: Английский
Citations
14
Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(17), P. 8847 - 8877
Published: Jan. 1, 2024
Significant advances have been made in materials for biomedical applications, including tissue engineering, bioimaging, cancer treatment,
Language: Английский
Citations
13
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 19, 2025
Cancer poses a substantial threat and serious challenge to public human health, driving the promotion of sophisticated technologies for cancer therapy. While conventional chemotherapy has bottlenecks such as low delivery efficiency, strong toxic side effects, tumor enrichment barriers, magnetic micro/nanorobots (MNRs) emerge promising therapeutic candidates that provide alternative strategies MNR is kind human-made machine micro- or nanosized, reasonably designed, performs command tasks through self-actuated externally controlled propulsion mechanisms, which can be potentially applied in theranostics. Here, this review first introduces components constitute typical MNR, including body part, control function sensing part. Subsequently, elucidates representative fabrication methods construct MNRs from top-down approaches bottom-up approaches, covering injection molding, self-rolling, melt electrospinning writing, deposition, biotemplate method, lithography, assembling, 3D printing, chemical synthesis. Furthermore, focuses on multiple applications facing diagnosis treatment, encompassing imaging, quantification, drug release, synergy with therapies, cell manipulation, surgical assistance. Then, systematically elaborates biocompatibility biosafety MNRs. Finally, challenges faced by are discussed alongside future research directions. This intended scientific guidance may improve comprehension cognition theranostics platform MNRs, promoting prospering practical application development
Language: Английский
Citations
1
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 381, P. 113589 - 113589
Published: March 1, 2025
The problem of antimicrobial resistance (AMR) has caused global concern due to its great threat human health. Evidences are emerging for a critical role biofilms, one the natural protective mechanisms developed by bacteria during growth, in resisting commonly used clinical antibiotics. Advances nanomedicines with tunable physicochemical properties and unique anti-biofilm provide opportunities solving AMR risks more effectively. In this review, we summarize five "A" stages (adhesion, amplification, alienation, aging allocation) biofilm formation through which they protect internal bacteria. Aimed at characteristics emphasize design "THAT" principles (targeting, hacking, adhering transport) their interactions biofilms Furthermore, recent progresses multimodal antibacterial nanomedicines, including disruption bactericidal activity, types currently available antibiofilm contained organic inorganic outlined highlighted potential applications development preclinical research. Last but not least, offer perspective effectiveness designed address challenges associated translation.
Language: Английский
Citations
1
Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: unknown, P. 137345 - 137345
Published: March 1, 2025
Language: Английский
Citations
1