Emerging Chemodynamic Nanotherapeutics for Cancer Treatment

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(22)

Published: May 16, 2024

Abstract Chemodynamic therapy (CDT) has emerged as a transformative paradigm in the realm of reactive oxygen species ‐mediated cancer therapies, exhibiting its potential sophisticated strategy for precise and effective tumor treatment. CDT primarily relies on metal ions hydrogen peroxide to initiate Fenton or Fenton‐like reactions, generating cytotoxic hydroxyl radicals. Its notable advantages treatment are demonstrated, including specificity, autonomy from external triggers, favorable side‐effect profile. Recent advancements nanomedicine devoted enhancing CDT, promising comprehensive optimization efficacy. This review systematically elucidates cutting‐edge achievements chemodynamic nanotherapeutics, exploring strategies enhanced improved microenvironment modulation, regulation energy metabolism. Moreover, detailed analysis diverse CDT‐mediated combination therapies is provided. Finally, concludes with discussion prospects intrinsic challenges application nanotherapeutics domain

Language: Английский

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Dendrimer/metal-phenolic nanocomplexes encapsulating CuO2 for targeted magnetic resonance imaging and enhanced ferroptosis/cuproptosis/chemodynamic therapy by regulating the tumor microenvironment

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 183, P. 252 - 263

Published: May 25, 2024

Language: Английский

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Metal–organic framework-based smart stimuli-responsive drug delivery systems for cancer therapy: advances, challenges, and future perspectives

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 28, 2025

Cancer treatment is currently one of the most critical healthcare issues globally. A well-designed drug delivery system can precisely target tumor tissues, improve efficacy, and reduce damage to normal tissues. Stimuli-responsive systems (SRDDSs) have shown promising application prospects. Intelligent nano responsive endogenous stimuli such as weak acidity, complex redox characteristics, hypoxia, active energy metabolism, well exogenous like high temperature, light, pressure, magnetic fields are increasingly being applied in chemotherapy, radiotherapy, photothermal therapy, photodynamic various other anticancer approaches. Metal–organic frameworks (MOFs) become candidate materials for constructing SRDDSs due their large surface area, tunable porosity structure, ease synthesis modification, good biocompatibility. This paper reviews MOF-based modes cancer therapy. It summarizes key aspects, including classification, synthesis, modifications, loading modes, stimuli-responsive mechanisms, roles different modalities. Furthermore, we address current challenges summarize potential applications artificial intelligence MOF synthesis. Finally, propose strategies enhance efficacy safety SRDDSs, ultimately aiming at facilitating clinical translation.

Language: Английский

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Metal‐Protein Hybrid Materials: Unlocking New Frontiers in Biomedical Applications

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Abstract Metal‐protein hybrid materials represent a novel class of functional that exhibit exceptional physicochemical properties and tunable structures, rendering them remarkable applications in diverse fields, including engineering, biocatalysis, biosensing, biomedicine. The design development multifunctional biocompatible metal‐protein have been the subject extensive research key aspiration for practical clinical settings. This review provides comprehensive analysis strategies, intrinsic properties, biomedical these materials, with specific emphasis on their potential cancer therapy, drug vaccine delivery, antibacterial treatments, tissue regeneration. Through rational design, stable can be synthesized using straightforward methods, enabling therapeutic, immunomodulatory, other desired functionalities. Finally, outlines existing limitations challenges associated evaluates translation, providing insights into implementation within applications.

Language: Английский

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Ti3C2Tx MXene quantum dots coated hollow manganese dioxide nanoparticles for tumor combination therapy and magnetic resonance imaging

Materials Today Chemistry, Journal Year: 2024, Volume and Issue: 39, P. 102171 - 102171

Published: June 24, 2024

Language: Английский

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Tumor Microenvironment-Activated In Situ Synthesis of Peroxynitrite for Enhanced Chemodynamic Therapy

ACS Nano, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 19, 2024

Chemodynamic therapy (CDT) can induce cancer cell death through hydroxyl radicals (·OH) generated from Fenton or Fenton-like reactions. Compared with traditional therapies, CDT effectively overcomes inevitable drug resistance and exhibits low side effects. However, clinical application still faces challenges, primarily due to insufficient ·OH generation the short-lifetime of in vivo. To address these we developed a peroxynitrite (ONOO

Language: Английский

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A multifunctional cascade enzyme system for enhanced starvation/chemodynamic combination therapy against hypoxic tumors

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 666, P. 244 - 258

Published: April 6, 2024

Language: Английский

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2D MOFs nanosheets derived from 2D LDHs as a multifunctional sensitizer for sono-photodynamic therapy-mediated tumor treatment

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159771 - 159771

Published: Jan. 1, 2025

Language: Английский

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A ferroptosis-reinforced nanocatalyst enhances chemodynamic therapy through dual H2O2 production and oxidative stress amplification

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 367, P. 892 - 904

Published: Feb. 24, 2024

Language: Английский

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Engineering Photothermal and H₂S‐Producing Living Nanomedicine by Bacteria‐Enabled Self‐Mineralization

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(34)

Published: May 14, 2024

Abstract Bacteria‐initiated cancer therapy has been demonstrated high therapeutic efficacy against cancer. However, the undesired and induced systematic inflammation storm compromise effect outcome. Herein, a thermally‐activated living nanomedicine composed of reactive biohybrid (designated as Sa@FeS) is rationally designed engineered for enhancing hydrogen sulfide (H 2 S)‐combined chemodynamic oncotherapy by biomineralizing ferrous nanoparticles (FeS NPs) onto surface Salmonella typhimurium strain (Sa) without reducing bacterial activity. Ascribed to deep penetration capability Sa, FeS NPs facilitate photothermally‐enhanced catalytic Fenton reaction decomposing endogenous H O into cytotoxic hydroxyl radicals in tumor tissues upon near infrared irradiation. Meanwhile, Sa bacteria maintain sustained S release within achieving S‐induced intracellular acidosis that favors generation oxygen species synergistically. Of note, thermally‐triggered all‐in‐one strategy effectively inhibits viability, thus risk ensuring biosafety. Therefore, nano‐bacteria system exerts thermally‐enhanced nanocatalytic gas therapies eradicate tumors, providing distinct paradigm combination synthetic biology therapy.

Language: Английский

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