Custom-designed
additives
play
a
crucial
role
in
achieving
desired
transformations
under
aqueous
conditions
modern
organic
synthesis.
In
micellar
catalysis,
designer
amphiphilic
molecules
create
dynamic
supramolecular
structures
that
can
dissolve
reactants
and
catalysts
conditions.
This
enables
the
to
occur
mild
without
need
for
hazardous
solvents.
Additionally,
such
as
tetra
-butyl
ammonium
chloride
or
bromides
facilitate
reactions
through
efficient
transfer
of
reactive
species
between
non-miscible
biphasic
systems.
method,
known
phase-transfer
has
been
instrumental
challenging
asymmetric
chapter
overviews
recent
advancements
these
respective
fields,
outlining
fundamental
principles
underlying
their
operational
mechanisms.
JACS Au,
Journal Year:
2024,
Volume and Issue:
4(2), P. 301 - 317
Published: Jan. 16, 2024
Water
is
considered
to
be
the
most
sustainable
and
safest
solvent.
Micellar
catalysis
a
significant
contributor
chemistry
in
water.
It
promotes
pathways
involving
water-sensitive
intermediates
transient
catalytic
species
under
micelles'
shielding
effect
while
also
replacing
costly
ligands
dipolar-aprotic
solvents.
However,
there
lack
of
critical
information
about
micellar
catalysis.
This
includes
why
it
works
better
than
traditional
organic
solvents,
specific
rules
differ
from
those
conventional
catalysis,
how
limitations
can
addressed
future.
Perspective
aims
highlight
current
gaps
our
understanding
provide
an
analysis
designer
surfactants'
origin
essential
components.
will
fundamental
including
aqueous
micelles
simultaneously
perform
multiple
functions
such
as
solvent,
ligand,
reaction
promoter.
Organic Process Research & Development,
Journal Year:
2024,
Volume and Issue:
28(4), P. 816 - 830
Published: March 14, 2024
From
the
context
of
sustainability,
contemporary
synthetic
organic
chemistry
practices
require
significant
transformation,
as
indicated
by
various
sustainability
matrices
like
atom
economy,
process
mass
intensity
(PMI),
E-factor,
and
DOZN.
These
factors
have
evidently
unveiled
inherent
inefficiencies
intrinsic
to
conventional
protocols
identified
solvents
principal
causative
agent.
In
response,
utilization
water
a
primary
reaction
medium
for
transformations
has
emerged
an
appealing
alternative.
This
approach
flourished
with
emergence
micellar
catalysis,
where
amphiphilic
molecules
alter
bulk
aqueous
medium's
solvation
properties
promote
desired
chemical
transformation
under
milder
sustainable
conditions.
After
2010,
this
technology
gained
considerable
momentum
established
foundational
framework
performing
reactions
conditions,
consequently
mitigating
dependency
on
hazardous
solvents.
perspective,
recent
advances
in
field
catalysis
will
be
discussed
industrial
applications,
along
future
directions
challenges
associated
regime.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(17), P. 2349 - 2352
Published: Jan. 1, 2024
A
sustainable
C(sp
2
)–C(sp
3
)
cross-electrophile
coupling
was
developed
between
readily
available
5-bromophthalide
and
1-benzyl-4-iodopiperidine
under
micellar
conditions,
leading
to
a
key
intermediate
of
one
our
development
compounds.
Analytical Chemistry,
Journal Year:
2023,
Volume and Issue:
95(44), P. 16407 - 16417
Published: Oct. 26, 2023
Regulation
of
the
reaction
pathways
is
a
perennial
theme
in
field
chemistry.
As
typical
chromogenic
substrate,
3,3′,5,5′-tetramethylbenzidine
(TMB)
generally
undertakes
one-electron
oxidation,
but
product
(TMBox1)
essentially
confused
complex
and
unstable,
which
significantly
hampers
clinic
bioassays
for
more
than
50
years.
Herein,
we
report
that
sodium
dodecyl
sulfate
(SDS)-based
micelles
could
drive
direct
two-electron
oxidation
TMB
to
final
stable
TMBox2.
Rather
activation
H2O2
oxidant
by
common
natural
peroxidase,
substrate
SDS
decoupled
thermodynamically
favorable
between
TMBox2
with
unreacted
TMB,
leading
an
unusual
pathway.
Mechanism
studies
demonstrated
complementary
spatial
electrostatic
isolation
effects,
caused
confined
hydrophobic
cavities
negatively
charged
outer
surfaces
micelles,
were
crucial.
Further
cascading
glucose
oxidase,
as
proof-of-concept
application,
allowed
be
reliably
measured,
even
broader
range
concentrations
without
any
conventional
strong
acid
termination.
Synthesis
of
water-stable
and
dispersible
heterogeneous
catalysts
having
high
catalytic
efficiency
is
more
challenging
compared
with
homogeneous
due
to
their
low
dispersity,
activity,
spatial
confinement
active
centers
in
bulk
water.
Herein,
we
are
describing
systematic
studies
for
the
development
microconfinement
participation
aqueous
micelles
via
temporal
surface
modification
porous
organic
polymer
derived
from
phosphine
ligands.
Detailed
investigations
using
various
techniques
such
as
transmission
electron
microscopy
(TEM),
scanning
(SEM),
tensiometry,
confocal
laser
(CLSM),
fluorescence
lifetime
imaging
(FLIM)
have
been
used
understand
role
micelles,
reagents,
materials
generation
microcolonies
Two-color
crossover
experiments
also
performed
exchange
reagents
or
vice
versa,
materials.
The
surfactant-modified
ligation
stabilization
palladium,
which
was
evidenced
by
high-resolution
(HR-TEM),
high-angle
annular
dark-field
(HAADF-STEM),
X-ray
photoelectron
spectroscopy
(XPS)
analysis.
act
confined
space
catalysis
water
showcasing
Suzuki-Miyaura
cross-coupling
reaction
a
ppm
level
Pd
loading
under
mild
conditions.
catalyst
found
be
recyclable
five
cycles;
easy
scale-up
C-C
couplings
additional
features.
Moreover,
these
data
provide
an
opportunity
revising
models
micellar
systems
that
underpin
sustainable
ACS Sustainable Chemistry & Engineering,
Journal Year:
2024,
Volume and Issue:
12(31), P. 11473 - 11479
Published: July 15, 2024
A
nonionic
surfactant
has
been
developed
from
agricultural
waste
and
its
potential
application
for
the
Ni-catalyzed
C–P
cross-coupling
reaction
in
water.
The
was
fully
characterized
by
various
spectroscopic
imaging
techniques.
size
of
micelles
morphological
changes
presence
catalysts/substrates
were
established
using
transmission
electron
microscopy
(TEM),
dynamic
light
scattering
(DLS),
confocal
microscopy.
Controlled
31P
NMR,
19F
mass
spectrometry,
X-ray
photoelectron
spectroscopy
(XPS)
analysis
revealed
possible
reactive
intermediates
mechanisms.
synthesis
shown
20
g
1
scale,
respectively.
The Journal of Physical Chemistry C,
Journal Year:
2025,
Volume and Issue:
129(18), P. 8708 - 8716
Published: March 5, 2025
Microscopic
insights
into
molecular
aggregation
have
been
obtained
using
R1,
a
model
solvatochromic
fluorophore
in
DMF–water
mixtures.
Fluorescence
quantum
yield
(ϕf)
and
lifetime
(τf)
of
R1
decrease
monotonically
up
to
rather
high
molar
ratio
water
(χH2O).
Near
invariance
the
hydrodynamic
radius,
estimated
fluorescence
correlation
spectroscopy,
assigns
this
progressive
increase
polarity
medium
not
aggregation.
An
abrupt
ϕf
beyond
critical
χH2O
marks
onset
R1.
Concomitantly,
decays
become
bimodal,
with
emergence
longer
component
associated
aggregates.
Significant
heterogeneity
is
observed
distribution
lifetimes,
indicating
existence
aggregates
different
kinds.
quenching,
upon
further
χH2O,
assigned
breakdown
smaller
ones.
A
qualitative
between
size
τf
by
imaging
microscopy.
Langmuir,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 6, 2024
In
recent
years,
the
issue
of
pharmaceutical
contaminants
in
water
bodies
has
emerged
as
a
significant
environmental
concern
owing
to
potential
negative
impacts
on
both
aquatic
ecosystems
and
human
health.
Consequently,
development
efficient
eco-friendly
methods
for
their
determination
removal
is
paramount
importance.
this
context,
surfactant
ensemble
sensor
been
explored
hard-to-sense
amphiphilic
drug,
i.e.,
amitriptyline.
Herein,
pyrene-based
amphiphile
chemoreceptor
was
synthesized
characterized
through
various
spectroscopic
techniques
such
1H,
13C
NMR,
single-crystal
XRD,
FTIR,
ES-mass
spectrometry.
Then,
dodecanoic
acid
(DA)
receptor
THF/water
solvent
system
were
used
generate
reverse
micelle-based
self-aggregates
SUPRAS
(SUPRAmolecular
Solvent).
The
structural
aspects,
morphology
size,
along
with
stability
aggregates
unfolded
microscopic
insights.
present
investigation
describes
synergistic
approach
that
combines
unique
properties
premicellar
concentration
supramolecular
promising
enhanced
amitriptyline
extraction
simultaneous
from
(LOD
=
12
nM).
To
evaluate
effectiveness
developed
real-world
scenarios,
experiments
conducted
determine
sensing
efficiency
among
pollutants
commonly
found
sources.
results
reveal
nanoensemble
exhibits
remarkable
ability,
toward
(AMT)
drug
outperforming
conventional
methods.
