Near-Infrared Light-Activatable DNA Tentacles for Efficient Inhibition of Tumor Metastasis by Bio-Orthogonal Cell Assembly DOI
Lingzhi Cao, Xinjian Yang, Yimei Li

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(27), P. 18046 - 18057

Published: June 27, 2024

Tumor metastasis remains a major challenge in cancer management. Among various treatment strategies, immune cell-based therapy holds great potential for inhibiting metastasis. However, its wide application is restricted by complex preparations, as well inadequate homing and controllability. Herein, we present groundbreaking approach bioorthogonally manipulating tumor-NK (natural killer) cell assembly to inhibit tumor Multiple dibenzocyclootyne (DBCO) groups decorated long single-stranded DNA were tail-modified on core–shell upconversion nanoparticles (CSUCNPs) condensed photosensitive chemical linker (PC-Linker) shield most of the DBCO groups. On one hand, light-triggered scaffolds formed cross-linked network click chemistry, effectively impeding migration. other efficient cellular facilitated effective communication between cells NK-92 cells, leading enhanced response against tumors further suppression These features make our strategy highly applicable range metastatic cancers.

Language: Английский

Magnetogenetics as a promising tool for controlling cellular signaling pathways DOI Creative Commons
Anastasiia A. Latypova, Alexey V. Yaremenko,

Nadezhda A. Pechnikova

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: June 10, 2024

Language: Английский

Citations

6
Preparation of immunomagnetic composite nanostructures with bifunctional four-arm PEG derivatives as linkers for the ultrafast enrichment of zearalenone and its metabolites DOI
Jiawei Liu,

Minli Yang,

Fengming Chen

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 472, P. 134321 - 134321

Published: April 29, 2024

Language: Английский

Citations

5
A Wurster-Type Covalent Organic Framework with Internal Electron Transfer-Enhanced Catalytic Capacity for Tumor Therapy DOI
Yang Liu, Huan Zhao, Shihuai Wang

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 24, 2024

The low immunogenicity of tumors, along with the abnormal structural and biochemical barriers tumor-associated vasculature, impedes infiltration function effector T cells at tumor site, severely inhibiting efficacy antitumor immunotherapy. In this study, a cobaloxime catalyst STING agonist (MSA-2)-coloaded Wurster-type covalent organic framework (Co-TB COF-M) internal electron transfer-enhanced catalytic capacity was developed as COF-based immune activator. covalently anchored adjusts energy band structure TB COF provides it good substrate adsorption sites, enabling to act an transmission bridge between in proton reduction reactions. This property significantly enhances sonodynamic performance. Under sono-irradiation, Co-TB COF-M can produce substantial amount reactive oxygen species (ROS) induce Gasdermin D-mediated pro-inflammatory pyroptosis, thereby effectively enhancing tumors. Furthermore, MSA-2 is specifically released response ROS minimizing off-target side effects. More importantly, COF-induced activation normalizes vasculature increases expression endothelial cell adhesion molecules, which greatly enhance cells. Thus, activator could remold microenvironment, leading increased improved for

Language: Английский

Citations

5
Mild magnetothermal enhanced nanocatalytic immunotherapy for solid tumors by immune cell activation and intratumoral infiltration DOI
Hao Fu, Lizhu Chen,

Wenming Fang

et al.

Nano Today, Journal Year: 2023, Volume and Issue: 52, P. 101987 - 101987

Published: Sept. 11, 2023

Language: Английский

Citations

13
Combined mild magnetic hyperthermia and calcium ion regulation for enhanced immunotherapy of orthotopic liver cancer DOI
Lizhu Chen, Weiwei Ren, Qunqun Bao

et al.

Nano Today, Journal Year: 2024, Volume and Issue: 56, P. 102284 - 102284

Published: April 27, 2024

Language: Английский

Citations

4
Mitochondria-loading erythrocytes transfer mitochondria to ameliorate inflammatory bone loss DOI
Shi Cheng, Zhou Lu, Wuyin Wang

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Redefining Hepatocellular Carcinoma Treatment: Nanotechnology Meets Tumor Immune Microenvironment DOI
Chen Mi, Sai Liu, Zhida Chen

et al.

Journal of drug targeting, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 47

Published: March 13, 2025

Hepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide, characterized by its complex pathogenesis and poor therapeutic outcomes. Despite recent advances in targeted molecular therapies, immune checkpoint inhibitors (ICIs), radiotherapy, conventional chemotherapy, five-year survival rate for this neoplasm remains dismally low. The progress nanotechnology has revolutionized cancer treatment years. These provide unprecedented opportunities to overcome current limitations different modalities. This review provides a comprehensive analysis how interfaces with tumor microenvironment (TIME) HCC can present new frontier interventions HCC. We critically overview latest developments nanoparticle-based delivery systems various drugs also other antitumor agents like thermal therapy radiotherapy. highlight unique ability nanoparticles modulate immunosuppressive (TME) enhance efficacy. Furthermore, we analyze emerging strategies that exploit nanoformulations biological barriers drug bioavailability treatment.

Language: Английский

Citations

0
Biomaterial-Mediated Exogenous Facile Coating of Natural Killer Cells for Enhancing Anticancer Efficacy toward Hepatocellular Carcinoma DOI
Ashok Kumar Jangid, Sungjun Kim, Hyun Jin Kim

et al.

Bioconjugate Chemistry, Journal Year: 2023, Volume and Issue: 34(10), P. 1789 - 1801

Published: Sept. 20, 2023

Natural killer (NK) cells exhibit a good therapeutic efficacy against various malignant cancer cells. However, the of plain NK is relatively low due to inadequate selectivity for Therefore, enhance targeting and anticancer cells, we have rationally designed biomaterial-mediated ex vivo surface engineering technique membrane decoration recognition ligands onto Our lipid conjugate biomaterial contains three major functional moieties: (1) 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) cell anchoring, (2) polyethylene glycol intracellular penetration blocker, (3) lactobionic acid (LBA) recognition. The was successfully applied surfaces (LBA-NK) functionalities, especially toward asialoglycoprotein receptor (ASGPR)-overexpressing hepatocellular carcinoma. Highly efficient homogeneous editing achieved with simple coating process while maintaining intrinsic properties LBA-NK showed potential ASGPR-mediated tumor binding (through LBA-ASGPR interaction) thereby significantly augmented efficacies HepG2 liver Thus, can be novel strategy treatment cancers via facilitated immune synapse interactions in comparison currently available therapies.

Language: Английский

Citations

10
Engineering nanozyme immunomodulator with magnetic targeting effect for cascade-enzyodynamic and ultrasound-reinforced metallo-immunotherapy in prostate carcinoma DOI Creative Commons
Yandong Wang, Haodong Li, Juntang Lin

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 22, 2025

Conventional immunotherapy exhibits low response rates due to the immunosuppressive tumor microenvironment (TME). To overcome this limitation, study introduces ZFPG nanoparticles (ZFPG NPs) with ZnFe2O4@Pt cores and glucose oxidase (GOx) shells. The NPs possess five-enzyme activities, good sonosensitivity, remarkable magnetic targeting properties, which facilitate sono-metallo-immunotherapy for prostate cancer treatment in male mice. Specifically, ability effectively improves their accumulation tumors while still showing enrichment liver kidneys. multienzyme cascade catalysis sonosensitivity of these deplete glutathione glucose, enhance generation utilization H2O2, thereby inducing multiple ROS bursts. Furthermore, comprehensive effects up-regulate HMOX1 promote Fe2+ lipid peroxides accumulation, immunogenic ferroptosis. This strategy facilitates anti-tumor immunity by ameliorating TME inhibiting lung metastatic progression. joint warfare offers a powerful solution address conventional limitations. Immunotherapy conventionally leads rate inadequate therapeutic efficacy. Here, authors issues developing nanozyme-based system sonosensitive magnetic-targeting capabilities mitigate body's immune response, achieving cancer.

Language: Английский

Citations

0
Nanocatalytic Anti‐Tumor Immune Regulation DOI
Mingyuan Li, Han Jiang, Ping Hu

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: 136(13)

Published: Jan. 12, 2024

Abstract Immunotherapy has brought a new dawn for human being to defeat cancer. Although existing immunotherapy regimens (CAR‐T, etc.) have made breakthroughs in the treatments of hematological cancer and few solid tumors such as melanoma, therapeutic efficacy on most is still far from satisfactory. In recent years, researches tumor based nanocatalytic materials are under rapid development, significant progresses been made. Nanocatalytic medicine demonstrated be capable overcoming limitations current clinicnal by using toxic chemodrugs, exhibits highly attractive advantages over traditional therapies, enhanced sustained durable catalytic activity, remarkably reduced harmful side‐effects without so on. Most recently, introduced immune‐regulation disease treatments, especially, immunoactivation therapies. This article presents immune‐response activations medicine‐initiated chemical reactions immunotherapy, elucidates mechanism medicines regulating anti‐tumor immunity. By reviewing research progress emerging field, this review will further highlight great potential broad prospects nanocatalysis‐based immune‐therapeutics.

Language: Английский

Citations

3