ACS Omega,
Journal Year:
2023,
Volume and Issue:
8(39), P. 36065 - 36075
Published: Sept. 22, 2023
Covalent
organic
framework
(COF)
materials
have
greatly
expanded
their
range
in
a
variety
of
applications
since
the
cognitive
goal
highly
organized
and
durable
adsorbent
is
quite
rational.
The
characteristics
conjugated
are
combined
with
an
industrially
relevant
polymer
to
produce
composite
membrane
optimized
for
selectively
adsorbing
carbon
dioxide
(CO2)
gas
across
wide
temperature
range.
Additionally,
treatment
cold
atmospheric
plasma
(CAP)
that
specifically
enhanced
parent
membrane's
surface
area
by
36%
established.
Following
CAP
treatment,
accelerates
CO2
uptake
as
much
66%.
This
primarily
due
Lewis
acid-base
interaction
between
electron-deficient
atom
newly
acquired
functionalities
on
COFs@PVDF
surface.
In
particular,
C-N
bonds,
which
appear
be
higher
electron
density
site,
play
key
role
this
interaction.
Moreover,
empirical
model
proposed
here
has
confirmed
adsorption
phenomena
COF@PVDF
membrane,
closely
matches
findings
from
experimental
data
set
under
designated
operating
conditions.
As
result,
current
study
may
pave
way
future
design
work
well
refine
covalent
features,
revealing
more
sophisticated
approach
addressing
capture
problems.
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
146(1), P. 858 - 867
Published: Dec. 30, 2023
Recombinant
enzymes
have
gained
prominence
due
to
their
diverse
functionalities
and
specificity
are
often
a
greener
alternative
in
biocatalysis.
This
context
makes
purifying
recombinant
from
host
cells
other
impurities
crucial.
The
primary
goal
is
isolate
the
pure
enzyme
of
interest
ensure
its
stability
under
ambient
conditions.
Covalent
organic
frameworks
(COFs),
renowned
for
well-ordered
structure
permeability,
offer
promising
approach
histidine-tagged
(His-tagged)
enzymes.
Furthermore,
immobilizing
within
COFs
represents
growing
field
heterogeneous
In
this
study,
we
developed
flow-based
technology
utilizing
nickel-infused
covalent
framework
(Ni-TpBpy
COF)
combine
two
distinct
processes:
purification
His-tagged
immobilization
simultaneously.
Our
work
primarily
focuses
on
three
β-glucosidase,
cellobiohydrolase,
endoglucanase
as
well
proteins
with
varying
molecular
weights,
namely,
green
fluorescent
protein
(27
kDa)
BG
Rho
(88
kDa).
We
employed
Ni-TpBpy
column
matrix
showcase
versatility
our
system.
Additionally,
successfully
obtained
COF
immobilized
enzymes,
which
can
serve
catalyst
hydrolysis
p-nitrophenyl-β-d-glucopyranoside
carboxymethylcellulose.
These
demonstrated
catalytic
activity
comparable
that
free
counterparts,
added
advantages
recyclability
enhanced
conditions
an
extended
period,
ranging
60
90
days.
contrasts
do
not
maintain
effectively
over
time.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(31), P. 40371 - 40390
Published: July 29, 2024
Enzymes,
a
class
of
biocatalysts,
exhibit
remarkable
catalytic
efficiency,
specificity,
and
selectivity,
governing
many
reactions
that
are
essential
for
various
cascades
within
living
cells.
The
immobilization
structurally
flexible
enzymes
on
appropriate
supports
holds
significant
importance
in
facilitating
biomimetic
transformations
extracellular
environments.
Covalent
organic
frameworks
(COFs)
have
emerged
as
ideal
candidates
enzyme
due
to
high
surface
tunability,
diverse
chemical/structural
designs,
exceptional
stability,
metal-free
nature.
Various
techniques
been
proposed
fabricate
COF-enzyme
biocomposites,
offering
enhancements
activity
reusability
COF-immobilized
well
new
insights
into
developing
advanced
enzyme-based
applications.
In
this
review,
we
provide
comprehensive
overview
state-of-the-art
strategies
immobilizing
COFs
by
focusing
their
applicability
versatility.
These
systematically
summarized
compared
categorizing
them
postsynthesis
situ
immobilization,
where
respective
strengths
limitations
thoroughly
discussed.
Combined
with
an
critical
emerging
applications,
further
elucidate
the
multifaceted
roles
subsequent
highlighting
biofunctionality
achievable
through
COFs.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(13)
Published: Feb. 7, 2024
β-Keto-enamine-linked
2D
covalent
organic
frameworks
(COFs)
have
emerged
as
highly
robust
materials,
showing
significant
potential
for
practical
applications.
However,
the
exclusive
reliance
on
1,3,5-triformylphloroglucinol
(Tp
aldehyde)
in
design
of
such
COFs
often
results
production
non-porous
amorphous
polymers
when
combined
with
certain
amine
building
blocks.
Attempts
to
adjust
crystallinity
and
porosity
by
a
modulator
approach
are
inefficient
because
Tp
aldehyde
readily
forms
stable
β-keto-enamine-linked
monomers/oligomers
various
aromatic
amines
through
an
irreversible
keto-enol
tautomerization
process.
Our
research
employed
unique
protection-deprotection
strategy
enhance
squaramide-based
COFs.
Advanced
solid-state
NMR
studies,
including
1D
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Nov. 6, 2024
Covalent
organic
frameworks
have
emerged
as
a
thriving
family
in
the
realm
of
photocatalysis
recently,
yet
with
concerns
about
their
high
exciton
dissociation
energy
and
sluggish
charge
transfer.
Herein,
strategy
to
enhance
built-in
electric
field
series
β-keto-enamine-based
covalent
by
ionic
polarization
method
is
proposed.
The
achieved
through
distinctive
post-synthetic
quaternization
reaction
which
can
endow
separated
centers
comprising
cationic
skeleton
iodide
counter-anions.
stronger
generated
between
framework
anions
promotes
transfer
efficiency.
Moreover,
introduced
not
only
serve
lowered
H*
formation
barrier,
but
also
act
electron
extractant
suppressing
recombination
electron-hole
pairs.
Therefore,
photocatalytic
performance
shows
notable
improvement,
among
CH3I-TpPa-1
deliver
an
H2
production
rate
up
9.21
mmol
g−1
h−1
without
any
co-catalysts,
representing
42-fold
increase
compared
TpPa-1,
being
comparable
or
possibly
exceeding
current
photocatalysts
addition
Pt
co-catalysts.
(COFs)
show
great
promise
are
limited
slow
Here,
authors
report
COFs
via
polarization,
resulting
hydrogen
evolution
g-¹
h-¹
Small,
Journal Year:
2023,
Volume and Issue:
20(15)
Published: Nov. 27, 2023
Abstract
Herein,
a
series
of
imine‐linked
covalent
organic
frameworks
(COFs)
are
developed
with
advanced
ordered
mesoporous
hollow
spherical
nanomorphology
and
ultra‐large
mesopores
(4.6
nm
in
size),
named
OMHS‐COF‐M
(M
=
H,
Co,
Ni).
The
is
revealed
to
be
formed
via
an
Ostwald
ripening
mechanism
based
on
one‐step
self‐templated
strategy.
Encouraged
by
its
unique
structural
features
outstanding
photoelectrical
property,
the
OMHS‐COF‐Co
material
applied
as
photocatalyst
for
CO
2
‐to‐CO
reduction.
Remarkably,
it
delivers
impressive
production
rate
high
15
874
µmol
g
−1
h
,
large
selectivity
92.4%,
preeminent
cycling
stability.
From
in/ex
situ
experiments
density
functional
theory
(DFT)
calculations,
excellent
photoreduction
performance
ascribed
desirable
cooperation
host
abundant
isolated
Co
active
sites,
enhancing
activation,
improving
electron
transfer
kinetics
well
reducing
energy
barriers
intermediates
*COOH
generation
desorption.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 11, 2024
Abstract
Persistent
challenges
in
hydroformylation
of
olefins
include
controlling
regioselectivity,
particularly
for
short
aliphatic
and
conducting
reactions
under
ambient
conditions.
We
report
here
the
synthesis
monophosphine–Rh
complexes
on
a
typical
chelated
diphosphine
ligand
mediated
by
Zr‐MOF
through
isolating
pair
phosphorus
atoms.
demonstrate
that
single‐crystal
X‐ray
diffraction
can
elucidate
structural
transformation
Rh
catalyst
during
olefin
hydroformylation,
providing
valuable
information
active
site
reconstruction
catalysis.
The
Rh‐MOF
demonstrates
excellent
catalytic
recyclable
performance
with
linear
to
branched
ratios
up
99
:
1.
Due
framework‘s
capacity
adsorb
concentrate
gases,
occur
room
temperature
pressure,
eliminating
need
high
pressures
typically
required
homogeneous
systems.
This
study
show
Zr–MOF
be
unique
platform
synthesizing
unusual
species
cannot
exist
solutions
meaningful
chemical
transformations
pertaining
metal‐based
ACS Biomaterials Science & Engineering,
Journal Year:
2024,
Volume and Issue:
10(7), P. 4227 - 4236
Published: June 7, 2024
Anticancer
drugs
are
often
associated
with
limitations
such
as
poor
stability
in
aqueous
solutions,
limited
cell
membrane
permeability,
nonspecific
targeting,
and
irregular
drug
release
when
taken
orally.
One
possible
solution
to
these
problems
is
the
use
of
nanocarriers
molecules,
particularly
those
targeting
ability,
stimuli-responsive
properties,
high
loading
capacity.
These
can
improve
stability,
increase
cellular
uptake,
allow
specific
cancer
cells,
provide
controlled
release.
While
improving
therapeutic
efficacy
drugs,
contemporary
researchers
also
aim
reduce
their
side
effects,
that
patients
offered
a
more
effective
targeted
treatment
strategy.
Herein,
set
nine
porous
covalent
organic
frameworks
(COFs)
were
tested
delivery
nanocarriers.
Among
these,
paclitaxel
loaded
COF-3
was
most
against
proliferation
ovarian
cells.
This
study
highlights
emerging
potential
COFs
field
delivery.
Due
biocompatibility,
viable
substrate
for
release,
making
them
attractive
candidates
systems.
work
demonstrates
efficient
agents,
thereby
opening
up
new
opportunities
sarcoma
therapy.
Chemistry - A European Journal,
Journal Year:
2023,
Volume and Issue:
30(6)
Published: Dec. 11, 2023
Abstract
The
implacable
rise
of
carbon
dioxide
(CO
2
)
concentration
in
the
atmosphere
and
acute
water
stress
are
one
central
challenges
our
time.
Present‐day
chemistry
is
strongly
inclined
towards
more
sustainable
solutions.
Covalent
organic
frameworks
(COFs),
attributable
to
their
structural
designability
with
atomic
precision,
functionalizable
chemical
environment
robust
extended
architectures,
have
demonstrated
promising
performances
CO
trapping
harvesting
from
air.
In
this
Review,
we
discuss
major
developments
field
as
well
sketch
out
opportunities
shortcomings
that
remain
over
large‐scale
COF
synthesis,
device
engineering,
long‐term
performance
real
environments.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 17, 2024
Rheumatoid
arthritis
(RA)
is
a
chronic
immune
disease
characterized
by
the
infiltration
of
cells
and
proliferation
fibroblast-like
synoviocytes
(FLS)
at
joint
site,
leading
to
inflammation
destruction.
However,
available
treatment
options
targeting
both
inflammatory
proliferative
FLS
are
limited.
Herein,
this
work
presents
three
covalent
organic
frameworks
(COFs)
photothermal
composite
systems
modified
with
multi-armed
polyethylene
glycols
(PEG)
for
RA.
These
exhibit
dual
response
under
low
pH
high
reactive
oxygen
species
(ROS)
conditions
site
inflammation,
specific
focus
on
delivering
protein
drug
ribonuclease
A
(RNase
A).
Notably,
molecular
docking
studies
reveal
interaction
between
RNase
NF-κB
p65
protein,
Western
blotting
confirm
its
inhibitory
effect
activity.
In
vitro
in
vivo
experiments
verify
significant
reduction
swelling
deformities
adjuvant-induced
(AIA)
rats
after
delivered
PEG-modified
COF
ligands,
restoring
morphology
normal.
findings
underscore
promising
therapeutic
potential
COFs
RA,
highlighting
their
unique
capabilities
addressing
aspects
expanding
scope
biomedical
applications
COFs.