Natural Products from Herbal Medicine Self‐Assemble into Advanced Bioactive Materials

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: July 21, 2024

Novel biomaterials are becoming more crucial in treating human diseases. However, many materials require complex artificial modifications and synthesis, leading to potential difficulties preparation, side effects, clinical translation. Recently, significant progress has been achieved terms of direct self-assembly natural products from herbal medicine (NPHM), an important source for novel medications, resulting a wide range bioactive supramolecular including gels, nanoparticles. The NPHM-based produced renewable resources, simple prepare, have demonstrated multi-functionality slow-release, smart-responsive release, especially possess powerful biological effects treat various In this review, revealed as emerging, revolutionary, promising strategy. development, advantages, limitations NPHM, well the advantageous position materials, first reviewed. Subsequently, systematic comprehensive analysis strategies specific seven major classes NPHM is highlighted. Insights into influence structural features on formation also provided. Finally, drivers preparations summarized, emphasizing biomedical applications, future scientific challenges, opportunities, with hope igniting inspiration research applications.

Language: Английский

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Colorimetric sensing for translational applications: from colorants to mechanisms

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(15), P. 7681 - 7741

Published: Jan. 1, 2024

This review summarizes insights into colorant selection and signal mechanisms for the development of colorimetric sensing POC sensors.

Language: Английский

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Metal–phenolic network composites: from fundamentals to applications

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(22), P. 10800 - 10826

Published: Jan. 1, 2024

This review provides a guideline for the rational design of metal–phenolic network (MPN) composites—which are fabricated from MPN and one or more functional components ( e.g. , drugs, proteins)—for various applications across diverse disciplines.

Language: Английский

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Self-assembly of stabilized droplets from liquid–liquid phase separation for higher-order structures and functions

Communications Chemistry, Journal Year: 2024, Volume and Issue: 7(1)

Published: April 9, 2024

Dynamic microscale droplets produced by liquid-liquid phase separation (LLPS) have emerged as appealing biomaterials due to their remarkable features. However, the instability of limits construction population-level structures with collective behaviors. Here we first provide a brief background in context materials properties. Subsequently, discuss current strategies for stabilizing including physical and chemical modulation. We also recent development LLPS various applications such synthetic cells biomedical materials. Finally, give insights on how stabilized can self-assemble into higher-order displaying coordinated functions fully exploit potentials bottom-up biology applications.

Language: Английский

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Multifunctional Metal–Phenolic Composites Promote Efficient Periodontitis Treatment via Antibacterial and Osteogenic Properties

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(11), P. 13573 - 13584

Published: March 5, 2024

Periodontitis, a complex inflammatory disease initiated by bacterial infections, presents significant challenge in public health. The increased levels of reactive oxygen species and the subsequent exaggerated immune response associated with periodontitis often lead to alveolar bone resorption tooth loss. Herein, we develop multifunctional metal–phenolic composites (i.e., Au@MPN-BMP2) address nature periodontitis, where gold nanoparticles (AuNPs) are coated networks (MPNs) morphogenetic protein 2 (BMP2). In this design, MPNs exhibit remarkable antibacterial antioxidant properties, AuNPs BMP2 promote osteogenic differentiation marrow mesenchymal stem cells under conditions. rat model treatment Au@MPN-BMP2 leads notable therapeutic outcomes, including mitigated oxidative stress, reduced progression inflammation, prevention These results highlight multifunctionality as promising approach for addressing both microbial causative factors an overactivated response. We envision that rational design will provide versatile nanoplatforms tissue regeneration potential clinical applications.

Language: Английский

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Facile universal strategy of presenting multifunctional short peptides for customizing desired surfaces

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 2, 2025

Interfacial properties determine biomaterial performances, such as cell adhesion, signal exchange, and biomineralization, which affect the tissue repair cycle efficiency of clinical applications. Peptides, short protein sequences that have defined functionalities, are highly stable easy to synthesize enormous potential reshape interfacial properties. However, lack a universal strategy for presenting peptides on various substrates substantially hinders application peptides. In this study, we report facile customizing desired functionalities by well-known layer-by-layer (LbL) technique through assembly polyphenols with positively charged peptide-coupling functional sequences. Polyphenol–peptide interactions were elucidated in detail assembling possessing different characteristics (charged, uncharged, hydrophobic, sequence length) combination molecular dynamics simulations, isothermal titration calorimetry further revealed favorable enthalpy change due electrostatic is main driving force polyphenols. LbL coatings assembled from exhibited good substrate generalization, stability, proliferation, antioxidant properties, when prepared hollow capsules sacrificing template, significant pH ultrasound stimulation responses, could be suitable candidates drug carriers. Most importantly, utilized present molecules (such arginyl–glycyl–aspartic acid (RGD), adhesion motif; CM15, an antibacterial peptide; PEG, antifouling surface) surfaces. This study not only provides new insights into understanding regulation between proteins/peptides but also paves way toward functionalization biomaterials.

Language: Английский

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Peptide-Based Biomimetic Condensates via Liquid–Liquid Phase Separation as Biomedical Delivery Vehicles

Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(9), P. 5468 - 5488

Published: Aug. 23, 2024

Biomolecular condensates are dynamic liquid droplets through intracellular liquid-liquid phase separation that function as membraneless organelles, which highly involved in various complex cellular processes and functions. Artificial analogs formed via similar pathways can be integrated with biological complexity advanced functions have received tremendous research interest the field of synthetic biology. The coacervate droplet-based compartments partition concentrate a wide range solutes, regarded attractive candidates for mimicking phase-separation behaviors biophysical features biomolecular condensates. use peptide-based materials phase-separating components has advantages such diversity amino acid residues customized sequence design, allows programming their physicochemical properties resulting compartments. In this Perspective, we highlight recent advancements design construction biomimicry from peptides relevant to protein, specific reference molecular self-assembly separation, biorelated applications, envisage emerging biomedical delivery vehicles.

Language: Английский

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Polyphenol-stabilized coacervates for enzyme-triggered drug delivery

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Aug. 24, 2024

Abstract Stability issues in membrane-free coacervates have been addressed with coating strategies, but these approaches often compromise the permeability of coacervate. Here we report a facile approach to maintain both stability and using tannic acid then demonstrate value this enzyme-triggered drug release. First, develop size-tunable via self-assembly heparin glycosaminoglycan tyrosine arginine-based peptides. A thrombin-recognition site within peptide building block results release upon thrombin proteolysis. Notably, polyphenols are integrated nano-coacervates improve biofluids. Phenolic crosslinking at liquid-liquid interface enables exceptional structural integrity across various environments. We discover pivotal polyphenol threshold for preserving enzymatic activity alongside enhanced stability. The disassembly rate increases as function activity, thus preventing coagulation cascade. This polyphenol-based not only improves also opens way applications biomedicine, protease sensing, bio-responsive delivery.

Language: Английский

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Coacervation‐Driven Semipermeable Nanoreactors for Enzymatic Cascade‐Mediated Cancer Combination Therapy with Enhanced Efficacy

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 5, 2024

Abstract Utilizing enzyme cascades as a promising approach for targeted cancer therapies holds significant potential, yet its clinical effectiveness is substantially hindered by functional losses during delivery. Complex coacervation emerges an intriguing strategy designing nanoreactors. In this study, noteworthy achievement presented in the development of lactobionic acid‐modified tumor microenvironment (TME)‐responsive polyelectrolyte complex vesicles (HGS‐PCVs) based on bioinspired homopolypeptoids, which serve facile, intelligent, and highly efficient nanoreactor tunable glucose oxidase, hemoglobin, sorafenib (SRF) to hepatic cells. The TME‐responsive permeability HGS‐PCVs enables selective entry into their interior, triggering enzymatic cascade reaction within tumor. This intricate process generates toxic hydroxyl radicals while concurrently lowering pH. Consequently, pH shift enhances SRF release, effectively promoting ferroptosis apoptosis target Further, administration not only initiates immunogenic cell death but also plays crucial role inducing maturation dendritic cells lymph nodes. It stimulates adaptive T‐cell response, mechanism that contributes impeding growth distant tumors vivo, demonstrating potential PCVs immunotherapy.

Language: Английский

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Supramolecular Assembly of Charge-Tunable Metal–Phenolic Networks

Chemistry of Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Controlling the surface charge of nanoassembled structures enables modulation their physicochemical properties and expands applications. Metal–phenolic networks (MPNs) typically yield materials with negatively charged surfaces. Herein, MPNs tunable were prepared using biscatechol-functionalized poly(2-vinylpyridine) (P2VP) various metal ions. The first assembly route yielded P2VP–FeIII MPN capsules that displayed pH-dependent reversal (∼ −10 mV at pH 12 to 20 2) facilitated fabrication hollow superstructures. Besides catechol–metal interaction, pyridinyl nitrogen–metal coordination continuous P2VP–CoII (e.g., capsule shell thickness increased from 26 nm over 24 h). second involving concurrent quaternization P2VP produced positively (i.e., QP2VP/P2VP–FeIII capsules) provided control (12–52 nm) (6–53 mV) time (1–8 h) 70 °C. surfaces enabled bioactive fluorescent regulation cell association depending on degree positive charge. This work selection or building blocks for designing systems.

Language: Английский

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