Chemical Science, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Near-infrared light-activated photocages enable controlling molecules with tissue penetrating light.
Language: Английский
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 518, P. 216117 - 216117
Published: July 27, 2024
Language: Английский
Citations
6
Aggregate, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 18, 2024
ABSTRACT Photodynamic therapy (PDT) and photothermal (PTT) have emerged promising applications in both fundamental research clinical trials. However, it remains challenging to develop ideal photosensitizers (PSs) that concurrently integrate high photostability, large near‐infrared absorptivity, efficient therapeutic capabilities. Herein, we reported a sample engineering strategy afford benzene‐fused Cy5 dimer ( Cy‐D‐5 ) for synergistically boosting PDT/PTT applications. Intriguingly, exhibits tendency form J ‐aggregates H phosphate‐buffered saline, which show long‐wavelength absorption band bathochromically shifted 810 nm short‐wavelength hypsochromically 745 nm, respectively, when compared its behavior ethanol (778 nm). Density‐functional theory calculations combined with time‐resolved transient optical spectroscopy analysis reveal the fused low Δ E ST (0.51 eV) non‐radiative transition rates (12.6 times greater than of clinically approved PS‐indocyanine green [PS‐ ICG ]). Furthermore, demonstrates higher photosensitizing ability produce 1 O 2 , stronger conversion efficiency η = 64.4%), photostability . These properties enable achieve complete tumor ablation upon 808 laser irradiation, highlighting potential as powerful dual‐function phototherapeutic agent. This work may offer practical other existing dyes red‐shifted spectral range various phototherapy
Language: Английский
Citations
5
JACS Au, Journal Year: 2024, Volume and Issue: 4(7), P. 2687 - 2694
Published: July 5, 2024
Hydrogen sulfide (H2S) is a gaseous signaling molecule, exerting crucial regulatory functions in organelles and cellular environments. H2S exhibits high therapeutic potential synergistic effects with other drugs, its potency notably enhanced through organelle-specific targeting. Yet, the navigation of light-activated donors to specific remains absent. Here, we report first photocage that simultaneously delivers payload subcellular precision mitochondria live human cells using tissue-penetrating near-infrared light as trigger. The fluorogenic enables real-time monitoring process, demonstrate concurrent uncaging combination fluorescence microscopy mitochondria-specific fluorescent probes. We anticipate these photocages will permit precise delivery H2S-drug combinations exceptional spatiotemporal control, thereby driving harnessing known discovery novel strategies.
Language: Английский
Citations
4
Chemical Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Photocages are protecting groups that can be unmasked with light irradiation and provide spatiotemporal control over the activity of a biomolecule.
Language: Английский
Citations
0
Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)
Published: April 18, 2025
Over the past decade, field of cell therapy has rapidly expanded with aim to replace and repair damaged cells and/or tissue. Depending on disease many different types can be used as part such a therapy. Here we focused potential treatment myocardial infarction, where currently available options are not able regenerate loss healthy heart We generated good manufacturing practice (GMP)-compatible cardiomyocytes (iCMs) from transgene- xenofree induced pluripotent stem (iPSCs) that seamless adapted for clinical applications. Further protocols were established replating freezing/thawing iCMs under conditions. showed cardiac phenotype, expression specific markers absence pluripotency at RNA protein level. To ensure pure population in vivo applications, minimized risks iPSC contamination using RNA-switch technology safety. describe generation further processing xeno- transgene-free iCMs. The use GMP-compliant differentiation ab initio facilitates translation this project later stages.
Language: Английский
Citations
0
JACS Au, Journal Year: 2025, Volume and Issue: unknown
Published: May 1, 2025
Language: Английский
Citations
0
Sensors and Actuators B Chemical, Journal Year: 2025, Volume and Issue: unknown, P. 137907 - 137907
Published: May 1, 2025
Language: Английский
Citations
0
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: July 9, 2024
Cultured meat is emerging as a new type of food that can provide animal protein in sustainable way. Many previous studies employed various types scaffolds to develop cultured with similar properties slaughtered meat. However, important such flavor were not discussed, even though they determine the quality food. Flavor characteristics vary dramatically depending on amount and amino acids sugars produce volatile compounds through Maillard reaction upon cooking. In this study, flavor-switchable scaffold developed release meaty only cooking temperature mimicking By introducing switchable compound (SFC) into gelatin-based hydrogel, we fabricate functional enhance aromatic The temperature-responsive SFC stably remains during cell culture period be released at temperature. Surprisingly, fabricated exhibits pattern beef. This research suggests strategy enhanced sensorial by developing which mimic natural flavors conventional
Language: Английский
Citations
3
Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: unknown, P. 110290 - 110290
Published: July 1, 2024
Language: Английский
Citations
3
Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
A NIR light-responsive phenothiazine based phototherapeutic system for synergistic cancer treatment.
Language: Английский
Citations
0