A review of innovative design strategies: Artificial antigen presenting cells in cancer immunotherapy DOI
Rabiya Altaf, Aditya Mohan,

Naveen Palani

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 125053 - 125053

Published: Dec. 1, 2024

Language: Английский

Invasion and metastasis in cancer: molecular insights and therapeutic targets DOI Creative Commons

Yongxing Li,

Fengshuo Liu,

Qingjin Cai

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Feb. 20, 2025

The progression of malignant tumors leads to the development secondary in various organs, including bones, brain, liver, and lungs. This metastatic process severely impacts prognosis patients, significantly affecting their quality life survival rates. Research efforts have consistently focused on intricate mechanisms underlying this corresponding clinical management strategies. Consequently, a comprehensive understanding biological foundations tumor metastasis, identification pivotal signaling pathways, systematic evaluation existing emerging therapeutic strategies are paramount enhancing overall diagnostic treatment capabilities for tumors. However, current research is primarily metastasis within specific cancer types, leaving significant gaps our complex cascade, organ-specific tropism mechanisms, targeted treatments. In study, we examine sequential processes elucidate driving organ-tropic systematically analyze tumors, those tailored organ involvement. Subsequently, synthesize most recent advances technologies challenges opportunities encountered pertaining bone metastasis. Our objective offer insights that can inform future practice crucial field.

Language: Английский

Citations

3
Reprogramming the Tumor Immune Microenvironment Through Activatable Photothermal Therapy and GSH depletion Using Liposomal Gold Nanocages to Potentiate Anti‐Metastatic Immunotherapy DOI
Jiayi Li,

Kaifan Zheng,

Luping Lin

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 2, 2024

Abstract Cancer immunotherapy offers significant clinical benefits for patients with advanced or metastatic tumors. However, immunotherapeutic efficacy is often hindered by the tumor microenvironment's high redox levels, leading to variable patient outcomes. Herein, a therapeutic liposomal gold nanocage (MGL) innovatively developed based on photo‐triggered hyperthermia and releasable strategy combining glutathione (GSH) depletion remodel immune microenvironment, fostering more robust anti‐tumor response. MGL comprises thermosensitive liposome shell core loaded maleimide. The flexible promotes efficient uptake cancer cells, enabling targeted destruction through photothermal therapy while triggering immunogenic cell death maturation of antigen‐presenting cells. photoactivated release maleimide depletes intracellular GSH, increasing sensitivity oxidative stress thermal damage. Conversely, GSH reduction also diminishes immunosuppressive activity, enhances antigen presentation, activates T Moreover, decreases elevated levels heat shock proteins in further their hyperthermia. In summary, elicited systemic antitumor response depletion, facilitating an effective that reprograms microenvironment significantly inhibits primary This approach demonstrates considerable translational potential applicability.

Language: Английский

Citations

4
Bisboronic Ester-Enabled Redox-Targeted Cancer Therapy: A Cascade ROS Consumption Approach for Efficient Elimination of Cancer Cells DOI

Silin Huang,

Yue Cui,

Boqiang Wang

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

Elevated levels of reactive oxygen species (ROS) in cancer cells, arising from their altered metabolism, represent a distinctive therapeutic target. Here, we introduce the first example bisboronic esters as potent agents for rapidly disrupting redox homeostasis, selectively inducing oxidative stress to eliminate cells. Structure-activity relationship studies revealed that both electronic and steric factors significantly influence cytotoxicity, with most effective compounds achieving IC50 values low 0.63 μM. Confocal imaging confirmed rapid intracellular depletion ROS, leading severe metabolic imbalance efficient cell death. This study highlights potential boronate-based therapeutics redox-targeted therapy, which may provide promising foundation development innovative anticancer strategies.

Language: Английский

Citations

0
Improving the Efficacy of Cancer mRNA Vaccines DOI
Ameya R. Kirtane, Giovanni Traverso

The Cancer Journal, Journal Year: 2025, Volume and Issue: 31(2)

Published: March 1, 2025

mRNA vaccines consist of antigen-encoding mRNA, which produces the antigenic protein upon translation. Coupling antigen production with innate immune activation can generate a potent, antigen-specific T-cell response. Clinical reports have demonstrated ability to elicit an anticancer response against various tumor types. Here, we discuss strategies enhance potency vaccines. We provide overview existing knowledge regarding and trafficking mechanisms share optimization boost mRNA-mediated production. In addition, address methods target dendritic cells lymph nodes, key initiators Finally, review for enhancing using adjuvants compatible offer unique advantages that be utilized oncology applications. However, significant work is needed understand their underlying develop technologies improve effectiveness.

Language: Английский

Citations

0
Self-Assembled Glycopeptide as a Biocompatible mRNA Vaccine Platform Elicits Robust Antitumor Immunity DOI
Yang Zhou,

Ye Wu,

Shengjie Sun

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Since the emergence of COVID-19 pandemic, mRNA vaccines have garnered significant attention. Delivery systems affect effectiveness vaccines, yet there remains a scarcity vectors that can achieve safe and efficient delivery mRNA. We took advantage self-assembled glycopeptides (SAPs) to develop vector named Man-MPm, which was coupled with mannose manganese ions lymph node targeting STING pathway activation. The Man-MPm-based vaccine exhibited high biosafety across various administration routes, eliciting robust antigen-specific immune responses within nodes. Due elevated antitumor immunity, Man-MPm significantly suppressed tumor growth extended survival period mice in melanoma prevention treatment models as well colon cancer model. Our findings show addresses challenges safety associated by incorporating node-targeting ligand agonist onto highly biocompatible SAP, holds great potential for developing vaccines.

Language: Английский

Citations

0
Paracyclophane-based ionizable lipids for efficient mRNA delivery in vivo DOI

Shiqi Wu,

Kexin Su, Xinxin Yan

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 376, P. 395 - 401

Published: Oct. 20, 2024

Language: Английский

Citations

3
Interaction design in mRNA delivery systems DOI
Mengyao Yu, Lixin Lin, Dezhong Zhou

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 377, P. 413 - 426

Published: Nov. 26, 2024

Language: Английский

Citations

2
Advances in COVID-19 and Cancer Research DOI Open Access
Laura Franza, Rossella Cianci

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(14), P. 4143 - 4143

Published: July 16, 2024

The global health crisis caused by COVID-19 has radically changed the management of several diseases [...]

Language: Английский

Citations

0
A review of innovative design strategies: Artificial antigen presenting cells in cancer immunotherapy DOI
Rabiya Altaf, Aditya Mohan,

Naveen Palani

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 125053 - 125053

Published: Dec. 1, 2024

Language: Английский

Citations

0