International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 287, P. 138616 - 138616
Published: Dec. 11, 2024
Language: Английский
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 14, 2025
Abstract Molecular phototheranostic dyes are of eminent interest for oncological diagnosis and imaging‐guided phototherapy. However, it remains challenging to develop photosensitizers (PSs) that simultaneously integrate high‐contrast photoacoustic imaging efficient therapeutic capabilities. In this work, a supramolecular strategy is employed construct molecular pair agent via the direct self‐assembly two cyanines, C5TNa (anionic) Cy‐Et (cationic). The Coulombic interactions between facilitate formation complementary cyanine (C5T‐ET) creation CT‐J‐type aggregates in water. This results completely quenched fluorescence significantly enhances nonradiative deactivation (≈22 ps), leading 3.3‐fold increase photothermal conversion efficiency 7.1‐fold enhancement response compared indocyanine green (ICG). As result, J‐type aggregate demonstrates high capability remarkable antitumor efficacy vivo, highlighting its potential clinical applications. work provides strong experimental evidence superior performance enhancing photosensitization response. It believed will propel advancement controllable dye J‐aggregates contribute practical implementation phototherapy vivo.
Language: Английский
Citations
1
Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
This minireview highlights recent developments in near-infrared organic photosensitizers for photodynamic cancer therapy. The challenges and future prospects of this promising research field are also discussed.
Language: Английский
Citations
0
Angewandte Chemie International Edition, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 31, 2025
The regulation of oxidative stress in living cells is essential for maintaining cellular processes and signal transduction. However, developing straightforward strategies to activate stress-sensitive membrane channels situ poses significant challenges. In this study, we present a chemiluminescence resonance energy transfer (CRET) system based on conjugated oligomer, oligo(p-phenylenevinylene)-imidazolium (OPV-Im), designed the activation transient receptor potential melastatin 2 (TRPM2) calcium by superoxide anion (O2⋅-) without requiring external light sources. OPV-Im oligomer targeted cell efficiently, leading TRPM2 CRET process subsequent intracellular overload. This cascade resulted mitochondrial damage inhibition autophagy, ultimately inducing apoptosis. Additionally, strategy could be applied selective killing tumor that overexpress ion inhibiting growth three-dimensional (3D) spheroids. Our offers novel approach regulating channel activity compared optogenetics photodynamic therapy.
Language: Английский
Citations
0
Angewandte Chemie, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 31, 2025
Abstract The regulation of oxidative stress in living cells is essential for maintaining cellular processes and signal transduction. However, developing straightforward strategies to activate stress‐sensitive membrane channels situ poses significant challenges. In this study, we present a chemiluminescence resonance energy transfer (CRET) system based on conjugated oligomer, oligo( p ‐phenylenevinylene)‐imidazolium (OPV−Im), designed the activation transient receptor potential melastatin 2 (TRPM2) calcium by superoxide anion (O ⋅ − ) without requiring external light sources. OPV−Im oligomer targeted cell efficiently, leading TRPM2 CRET process subsequent intracellular overload. This cascade resulted mitochondrial damage inhibition autophagy, ultimately inducing apoptosis. Additionally, strategy could be applied selective killing tumor that overexpress ion inhibiting growth three‐dimensional (3D) spheroids. Our offers novel approach regulating channel activity compared optogenetics photodynamic therapy.
Language: Английский
Citations
0
Biomaterials, Journal Year: 2025, Volume and Issue: 320, P. 123235 - 123235
Published: March 4, 2025
Language: Английский
Citations
0
Small, Journal Year: 2025, Volume and Issue: unknown
Published: March 3, 2025
Abstract “Molecular science” has long been regarded as the golden rule to guide design of organic materials’ performances in past many years, but some interesting phenomena conventional aggregation‐caused fluorescence quenching and new aggregation‐induced emission reflect that properties would be changed from “molecule” “aggregate”. Therefore, “molecular theory faces certain limitations regulating performance materials at aggregation. In this work, it is discovered photosensitizer's contain reactive oxygen species, which could affected by changing molecular atoms aggregation form. The introduction selenium redshift improve species (ROS) efficiency. addition atomic effect, ROS efficiency photosensitizers after coating a polymeric shell, is, production type II singlet ( 1 O 2 ) suppressed, while I superoxide anion (O −• improved. This work discovers are relevant effect discussing deeply influence mechanism, important research significance for modulating precisely promoting development photodynamic therapy.
Language: Английский
Citations
0
Science China Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: March 3, 2025
Language: Английский
Citations
0
ACS Sensors, Journal Year: 2025, Volume and Issue: unknown
Published: March 10, 2025
High-fidelity tracking of glycogen dynamics in living biosystems is critical for exploring the biological role metabolism diseases. However, situ information on state mainly relies a glucose uptake fluorescence probe 2-NBDG, which has proven to be extremely limited owing "always-on" fluorescence, short emission wavelength, and low signal-to-noise (S/N) ratio. Herein, we first time demonstrate metabolic-activated off-on through covalently attaching molecular rotor with hydrophilic at C-2 position guarantee good miscibility complete fluorescence-off before metabolic incorporation into particles. The Glycogen-Red achieves negligible background (1/30 times than 2-NBDG) an ultrahigh S/N ratio (61-fold lighting-up near-infrared (NIR) biosynthesis. Notably, our unique characteristic bypassing washing steps, offering powerful toolbox real-time biosynthesis super-resolution mapping structures cells.
Language: Английский
Citations
0
Small, Journal Year: 2025, Volume and Issue: unknown
Published: March 17, 2025
Abstract The reactive oxygen species (ROS) amplification caused by inevitable plasma albumin encapsulation is still a challenge to circumvent the systemic adverse effects in photodynamic therapy (PDT) process. Herein, disulfide bond linked homodimer, Cy1280, which modulated accurately balance fluorescence and ROS generation exhibit weak sealed PDT effect during blood circulation, exploited. Cy1280 can be specifically internalized dispersed at tumor site via Organic Anion Transporter Proteins (OATPs) thiol‐disulfide exchange mediated synergistic uptake activated after mild sunlight irradiation (100 ± 5 Klx) sensitize neighboring cellular mitochondria execute direct protein dysfunction effect. dynamic covalent chemistry (DCC) facilitates prolonged sustained retention tumors (>336 h) demonstrates efficacy of imaging‐guided solid‐tumor tumor‐bearing BALB/C mice. This study resolves stubborn impotent penetration bulky‐sized nanoparticles high interstitial pressure with manner, long‐term circulation manipulated also improve whole body phototoxic symptom. advantageous feature provides promising candidate for overcoming off‐target phototoxicity inadequate accumulation challenges clinical translation photosensitizers (PSs).
Language: Английский
Citations
0
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161711 - 161711
Published: March 1, 2025
Language: Английский
Citations
0