Angewandte Chemie International Edition,
Journal Year:
2019,
Volume and Issue:
58(40), P. 14357 - 14364
Published: July 31, 2019
A
large
range
of
nanoparticles
have
been
developed
to
encapsulate
hydrophobic
drugs.
However,
drug
loading
is
usually
less
than
10
%
or
even
1
%.
Now,
core-shell
are
fabricated
having
exceptionally
high
up
65
(drug
weight/the
total
weight
drug-loaded
nanoparticles)
and
encapsulation
efficiencies
(>99
%)
based
on
modular
biomolecule
templating.
Bifunctional
amphiphilic
peptides
designed
not
only
stabilize
but
also
induce
biosilicification
at
the
nanodrug
particle
surface
thus
forming
drug-core
silica-shell
nanocomposites.
This
platform
technology
highly
versatile
for
encapsulating
various
cargos.
Furthermore,
lead
better
in
vitro
cytotoxic
effects
vivo
suppression
tumor
growth,
highlighting
significance
using
drug-loading
nanoparticles.
ACS Applied Bio Materials,
Journal Year:
2020,
Volume and Issue:
4(1), P. 24 - 46
Published: July 10, 2020
Over
the
past
several
decades,
rapid
advances
have
been
made
in
application
of
nanomaterials
biomedical
field
including
bioimaging
and
drug
delivery.
Owing
to
natural
biocompatibility,
diverse
design,
dynamic
self-assembly,
peptides
can
be
used
as
modules
construct
self-assembled
peptide-based
nanomaterials,
which
a
high
potential
reducing
toxicity,
improving
targeting,
enhancing
delivery
efficiency.
In
this
review,
three
typical
design
strategies
peptide
for
summarized
ex
situ
construction,
morphological
transformation,
construction
systems
(PDDs).
Drugs
loaded
by
physical
encapsulation
or
chemical
conjugation
methods,
showing
enhanced
retention
effects
at
tumor
sites
increase
uptake
rate
drugs.
Interestingly,
drug-free
also
nanomedicines
These
implicate
bright
prospect
intelligent
nanomedicine
clinical
translation.
Advanced Functional Materials,
Journal Year:
2018,
Volume and Issue:
28(50)
Published: Sept. 21, 2018
Abstract
During
the
last
decade,
peptide‐based
nanomaterials
are
recognized
as
upcoming
biomedical
materials
for
tumor
imaging
and
therapy.
The
rapid
expansion
of
peptides
peptide
derivatives
is
almost
owing
to
their
excellent
biocompatibility,
diverse
bioactivity,
potential
biodegradability,
specific
biological
recognition
ability,
easy
chemical
modification
characteristic.
present
review
outlines
development
up
now
concerning
design
applications
multifunctional
nanomaterials,
with
an
emphasis
on
variegated
therapeutic
methods.
ACS Applied Materials & Interfaces,
Journal Year:
2019,
Volume and Issue:
11(40), P. 37147 - 37155
Published: Sept. 12, 2019
Drug-loading
hydrogels
are
promising
candidates
in
the
bioengineering
research
field;
nevertheless,
hydrophobic
drug
loading
into
a
hydrophilic
carrier
system
remains
unsolved
and
is
full
of
challenges.
In
this
work,
following
potential
dual
interactions
between
peptides
aromatic
drugs,
we
developed
potent
hybrid
hydrogel
formation
method,
namely,
"peptide-/drug-directed
self-assembly".
The
were
synthesized
using
polyethylene
glycol
(PEG)-based
Fmoc-FF
peptide
polyurethane,
which
curcumin
could
be
encapsulated
through
self-assembly
with
via
π-π
stacking.
On
basis
this,
capacity
improved
to
as
high
3.3
wt
%
sustained
release.
addition,
enhanced
mechanical
properties
from
4
kPa
over
10
kPa,
similar
that
natural
soft
tissues.
Furthermore,
injectable
self-healing
since
peptide/curcumin
coassembly
was
noncovalent
reversible.
Spectroscopy
results
confirmed
existence
peptide/curcumin.
Further
vivo
experiments
effectively
demonstrated
improve
cutaneous
wound
healing
full-thickness
skin
defected
model.
This
peptide-/drug-directed
polyurethane
used
platform
for
tissue-engineering
scaffold
biomedical
application.
ACS Nano,
Journal Year:
2020,
Volume and Issue:
14(4), P. 5121 - 5134
Published: April 13, 2020
Supramolecular
nanomaterials
as
drug
carriers
have
recently
received
increasing
attention
due
to
their
intrinsic
merits
such
high
stability,
strong
inclusion
capability,
and
facile
modification
of
the
parental
structure;
however,
intelligent
ones
with
combined
capacities
long
blood
circulation,
highly
efficient
tumor
cell
uptake,
site-oriented
release
inside
cells
are
still
rather
limited.
Herein,
we
report
a
strategy
using
supramolecular
aggregation-induced
emission
(AIE)
nanodots
for
image-guided
delivery,
which
integrate
both
advantages
AIE
nanomaterials.
The
dots
prepared
by
host-guest
coassembly
matrix
metalloproteinase-2
(MMP-2)
sensitive
PEG-peptide
(PEG2000-RRRRRRRR
(R8)-PLGLAG-EKEKEKEKEKEK
(EK6))
functional
α-cyclodextrins
(α-CD)
derivatives
that
conjugated
anticancer
gemcitabine
(GEM)
far-red/near-infrared
fluorescent
rhodanine-3-acetic
acid-based
luminogen,
respectively.
realize
circulation
time
virtue
zwitterionic
stealth
peptide
EK6.
After
largely
accumulating
in
tissues
enhanced
permeability
retention
effect,
can
successively
respond
tumor-overexpressed
MMP-2
intracellular
reductive
microenvironment,
achieving
cancer
cellular
uptake
selective
GEM
within
cells,
thus
exhibit
excellent
inhibition
ability
subcutaneous
orthotopic
pancreatic
models.
Angewandte Chemie International Edition,
Journal Year:
2019,
Volume and Issue:
58(40), P. 14357 - 14364
Published: July 31, 2019
A
large
range
of
nanoparticles
have
been
developed
to
encapsulate
hydrophobic
drugs.
However,
drug
loading
is
usually
less
than
10
%
or
even
1
%.
Now,
core-shell
are
fabricated
having
exceptionally
high
up
65
(drug
weight/the
total
weight
drug-loaded
nanoparticles)
and
encapsulation
efficiencies
(>99
%)
based
on
modular
biomolecule
templating.
Bifunctional
amphiphilic
peptides
designed
not
only
stabilize
but
also
induce
biosilicification
at
the
nanodrug
particle
surface
thus
forming
drug-core
silica-shell
nanocomposites.
This
platform
technology
highly
versatile
for
encapsulating
various
cargos.
Furthermore,
lead
better
in
vitro
cytotoxic
effects
vivo
suppression
tumor
growth,
highlighting
significance
using
drug-loading
nanoparticles.
