Liposomes for Enhanced Bioavailability of Water-Insoluble Drugs: In Vivo Evidence and Recent Approaches

Pharmaceutics, Journal Year: 2020, Volume and Issue: 12(3), P. 264 - 264

Published: March 13, 2020

It has been known that a considerable number of drugs in clinical use or under development are water-insoluble with poor bioavailability (BA). The liposomal delivery system drawn attention as one the noteworthy approaches to increase dissolution and subsequently absorption gastrointestinal (GI) tract because its biocompatibility ability encapsulate hydrophobic molecules lipid domain. However, there have several drawbacks, such structural instability GI permeability across intestinal epithelia relatively large size. In addition, no formulations approved for oral date, despite success parenteral liposomes. Nevertheless, resurged rapid published studies last decade. it is discouraging most this research vitro only not many vivo data. present review focused on evidence improved BA using liposomes resolve doubts raised concerning attempted provide insight by highlighting used achievements.

Language: Английский

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Nanoparticles Targeting Macrophages as Potential Clinical Therapeutic Agents Against Cancer and Inflammation

Frontiers in Immunology, Journal Year: 2019, Volume and Issue: 10

Published: Aug. 21, 2019

With the development of nanotechnology, significant progress has been made in design and manufacture nanoparticles (NPs) for use clinical treatments. Meanwhile, recent increases our understanding central role macrophages context inflammation cancer have reinvigorated interest as a drug target. Macrophages serve an integral maintaining steady state immune system are involved processes inflammation. Thus, tailored needed to accurately target potential transform disease treatment. Herein, we firstly present brief background information NPs carriers including but not limited types nanomaterial, their biological properties advantages application. Then macrophage effector mechanisms NP-based strategies aiming at targeting by eliminating or re-educating summarized. Additionally, nano-carriers diagnosis also discussed. Finally, significance macrophage-targeting nanomedicine is highlighted, with goal facilitating future translation.

Language: Английский

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Nanoemulsions for drug delivery

Particuology, Journal Year: 2021, Volume and Issue: 64, P. 85 - 97

Published: June 8, 2021

Emulsions are liquid–liquid dispersions with one liquid phase dispersed in the other as small droplets. Nanoemulsions nano-sized emulsions sizes ranging from tens to hundreds of nanometers, and have great potential applications pharmaceutics, foods cosmetics due their attractive properties, such sizes, high surface area per unit volume, improved dispersion active hydrophobic components enhanced absorption. The article provides an overview nanoemulsions for drug delivery, starting introduction emulsion types, nanoemulsion preparation stability. Surfactants play critical roles producing stabilizing nanoemulsions. Different types surfactants summarized including molecule surfactants, particle phospholipids, peptide protein surfactants. Then nanomedicine delivery presented. Finally, clinical discussed.

Language: Английский

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Unique Properties of Surface-Functionalized Nanoparticles for Bio-Application: Functionalization Mechanisms and Importance in Application

Nanomaterials, Journal Year: 2022, Volume and Issue: 12(8), P. 1333 - 1333

Published: April 13, 2022

This review tries to summarize the purpose of steadily developing surface-functionalized nanoparticles for various bio-applications and represents a fascinating rapidly growing field research. Due their unique properties-such as novel optical, biodegradable, low-toxicity, biocompatibility, size, highly catalytic features-these materials are considered superior, it is thus vital study these systems in realistic meaningful way. However, rapid aggregation, oxidation, other problems encountered with functionalized nanoparticles, inhibiting subsequent utilization. Adequate surface modification organic inorganic compounds results improved physicochemical properties which can overcome barriers. investigates discusses iron oxide gold platinum silver silica-coated how after fabrication allow potential use wide range such nano-based imaging, gene delivery, drug loading, immunoassays. The different groups advantages functionalization applications highlighted here. In recent years, have become important broad bio-applications.

Language: Английский

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Formulation of Nanoparticles Using Mixing-Induced Nanoprecipitation for Drug Delivery

Industrial & Engineering Chemistry Research, Journal Year: 2019, Volume and Issue: 59(9), P. 4134 - 4149

Published: Dec. 18, 2019

Significant efforts have been made to fabricate drug-loaded nanoparticles for drug delivery. Nanoprecipitation is a simple and versatile method making various types of polymer with well-controlled particle size, size distribution, surface properties. This review presents critical overview three different widely used nanoprecipitation techniques, namely, traditional in bulk solutions, flash nanoprecipitation, microfluidic-based nanoprecipitation. The starts the comparison these methods summarizing their key characteristics, advantages, disadvantages. Then, synthesized using are presented including di-block copolymer natural nanoparticles. A special focus placed on comparing prepared approaches synthesis methods, loading, encapsulation efficiency, nanoparticle properties (e.g., PDI, etc.), stability. Finally, principle forming discussed fundamentally understand intricate interplay between mixing, supersaturation, nucleation, growth, aiming provide general guideline based

Language: Английский

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Liquid‐Metal‐Assisted Programmed Galvanic Engineering of Core–shell Nanohybrids for Microwave Absorption

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(34)

Published: May 17, 2023

Abstract Core–shell nanostructures have received widespread attention because of their potential usage in various technological and scientific fields. However, they still face significant challenges terms fabrication core–shell nanostructure libraries on a controlled, even programmed scale. This study proposes general approach to systematically fabricate nanohybrids using liquid‐metal Ga alloys as reconfigurable templates, the initiation local galvanic replacement reaction is demonstrated utilizing an ultrasonic system. Under agitation, hydrated gallium oxides generated liquid metal droplets, simultaneously delaminated themselves from interfaces. Subsequently, single‐metal or bimetallic components are deposited fresh smooth Ga‐based via reactions form unique metal/metal nanohybrids. Controlled quantitative regulation diversity non‐homogeneous nanoparticle shell layer composition achieved. The obtained used efficient microwave absorbers dissipate unwanted electromagnetic wave pollution. effective absorption bands (90% absorption) GaNi GaCoNi 3.92 3.8 GHz at thickness 1.4 mm, respectively. advanced strategy enables growth other sulfides by spontaneous interfacial redox for functional materials future.

Language: Английский

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Functionalized silica nanoparticles: classification, synthetic approaches and recent advances in adsorption applications

Nanoscale, Journal Year: 2021, Volume and Issue: 13(38), P. 15998 - 16016

Published: Jan. 1, 2021

Silica nanoparticles have evolved from the field of nanotechnology to different fields science and engineering. An overview silica going definitions properties, synthetic approaches applications is presented.

Language: Английский

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Towards principled design of cancer nanomedicine to accelerate clinical translation

Materials Today Bio, Journal Year: 2022, Volume and Issue: 13, P. 100208 - 100208

Published: Jan. 1, 2022

Nanotechnology in medical applications, especially oncology as drug delivery systems, has recently shown promising results. However, although these advances have been the pre-clinical stages, clinical translation of this technology is challenging. To create systems with increased treatment efficacy for translation, physicochemical characteristics nanoparticles such size, shape, elasticity (flexibility/rigidity), surface chemistry, and charge can be specified to optimize efficiency a given application. Consequently, interdisciplinary researchers focused on producing biocompatible materials, production technologies, or new formulations efficient loading, high stability. The effects design parameters studied

Language: Английский

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Organic Optoelectronic Materials: A Rising Star of Bioimaging and Phototherapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(17)

Published: Aug. 19, 2023

Abstract Recently, many organic optoelectronic materials (OOMs), especially those used in light‐emitting diodes (OLEDs), solar cells (OSCs), and field‐effect transistors (OFETs), are explored for biomedical applications including imaging photoexcited therapies. In this review, recently developed OOMs fluorescence imaging, photoacoustic photothermal therapy, photodynamic summarized. Relationships between their molecular structures, nanoaggregation photophysical mechanisms, properties various discussed. Mainly four kinds of covered: thermally activated delayed OLEDs, conjugated small molecules polymers OSCs, charge‐transfer complexes OFETs. Based on the unique optical properties, excitation light wavelength exciton dynamics, they respectively exploited suitable applications. This review is intended to serve as a bridge researchers area devices Moreover, it provides guidance selecting or modifying high‐performance uses. Current challenges future perspectives also discussed with hope inspiring further development efficient

Language: Английский

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A Library of Polyphenol‐Amino Acid Condensates for High‐Throughput Continuous Flow Production of Nanomedicines with Ultra‐High Drug Loading

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Abstract Synthesizing high drug‐loading nanomedicines remains a formidable challenge, and achieving universally applicable, continuous, large‐scale engineered production of such presents even greater difficulties. This study scalable library polyphenol‐amino acid condensates. By selecting amino acids, the enables precise customization key properties, as carrier capacity, bioactivity, other critical attributes, offering versatile range options for various application scenarios. Leveraging properties solvent‐mediated disassembly reassembly condensates achieved an ultra‐high drug loading 86% paclitaxel. For poorly soluble molecules, capacity exceeded 50%, indicating broad applicability. Furthermore, employing continuous microfluidic device, rate can reach 5 mL min −1 (36 g per day), with nanoparticle size precisely tunable polydispersity index (PDI) below 0.2. The polyphenol‐based demonstrates efficient cellular uptake and, in three distinct animal models, has been shown to enhance therapeutic efficacy paclitaxel without significant side effects. streamlined, efficient, approach using microfluidics produce loading, promising strategy nanoformulation drugs.

Language: Английский

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