Gels,
Journal Year:
2022,
Volume and Issue:
8(4), P. 205 - 205
Published: March 24, 2022
Recently,
hydrogels
have
been
investigated
for
the
controlled
release
of
bioactive
molecules,
such
as
living
cell
encapsulation
and
matrices.
Due
to
their
remote
controllability
quick
response,
are
widely
used
various
applications,
including
drug
delivery.
The
rate
extent
which
drugs
reach
targets
highly
dependent
on
carriers
in
delivery
systems;
therefore
demand
biodegradable
intelligent
is
progressively
increasing.
nature
hydrogel
has
created
much
interest
its
use
systems.
first
part
this
review
focuses
emerging
fabrication
strategies
hydrogel,
physical
chemical
cross-linking,
well
radiation
cross-linking.
second
describes
applications
fields,
In
end,
an
overview
application
prepared
from
several
natural
polymers
presented.
ACS Nano,
Journal Year:
2021,
Volume and Issue:
15(8), P. 12687 - 12722
Published: Aug. 10, 2021
Hydrogels,
due
to
their
excellent
biochemical
and
mechnical
property,
have
shown
attractive
advantages
in
the
field
of
wound
dressings.
However,
a
comprehensive
review
functional
hydrogel
as
dressing
is
still
lacking.
This
work
first
summarizes
skin
healing
process
relates
evaluation
parameters
then
reviews
advanced
functions
dressings
such
antimicrobial
adhesion
hemostasis,
anti-inflammatory
anti-oxidation,
substance
delivery,
self-healing,
stimulus
response,
conductivity,
recently
emerged
monitoring
feature,
strategies
adopted
achieve
these
are
all
classified
discussed.
Furthermore,
applications
for
treatment
different
types
wounds
incisional
excisional
summarized.
Chronic
also
mentioned,
focus
attention
on
infected
wounds,
burn
diabetic
Finally,
future
directions
further
proposed.
Advanced Drug Delivery Reviews,
Journal Year:
2021,
Volume and Issue:
171, P. 240 - 256
Published: Feb. 7, 2021
Supramolecular
binding
motifs
are
increasingly
employed
in
the
design
of
biomaterials.
The
ability
to
rationally
engineer
specific
yet
reversible
associations
into
polymer
networks
with
supramolecular
chemistry
enables
injectable
or
sprayable
hydrogels
that
can
be
applied
via
minimally
invasive
administration.
In
this
review,
we
highlight
two
main
areas
where
being
used
drug
delivery
systems:
engineering
network
mechanics
and
tailoring
drug–material
affinity.
Throughout,
many
established
emerging
chemistries
useful
for
applications.
Advanced Functional Materials,
Journal Year:
2020,
Volume and Issue:
30(52)
Published: Oct. 1, 2020
Abstract
Wound
management
remains
a
major
concern
in
clinical
care.
Conventional
dressings
and
hydrogels
delivering
drugs
or
cells
can
drive
wound
healing.
However,
these
approaches
are
limited
either
by
unnecessary
bleeding
tissue
tearing,
sophisticated
fabrication,
high
cost,
drug‐related
side
effects.
Herein,
novel
bioinspired
glycopeptide
hydrogel
is
rationally
designed
to
mimic
the
glycoprotein
components
nanofibrous
architecture
of
cutaneous
extracellular
matrix
(ECM)
for
self‐accelerating
healing
regulating
macrophage
polarization
without
any
additional
therapeutic
agents.
The
hydrogel,
termed
as
GM‐peptide
hybrid
(GP
gel
),
established
self‐assembly
β‐sheet
Q11
peptide‐grafted
glucomannan,
with
structure,
water
content,
porosity,
self‐healing
properties.
It
observed
that
GP
displays
remarkable
capability
polarizing
primary
macrophages
M2‐type
phenotype
vitro
vivo
inducing
activation
mannose
receptors
through
ERK/STAT6
pathway.
unprecedentedly
expedites
closure
rate
regeneration
epidermis
tissues
full‐thickness
skin
excision
models
drugs,
exogenous
cytokines,
seeded
cells.
More
significantly,
could
promote
angiogenesis
repaired
tissues.
Collectively,
such
ECM‐mimicking
provides
highly
effective
treatment
approach
wounds
may
serve
promising
scaffold
regenerative
medicine.
Advanced Healthcare Materials,
Journal Year:
2022,
Volume and Issue:
11(13)
Published: April 15, 2022
Conventional
wound
closure
and
dressing
are
two
crucial,
time-consuming
but
isolated
principles
in
care.
Even
though
tissue
adhesive
opens
a
new
era
for
closure,
the
method
biomaterial
that
can
simultaneously
achieve
noninvasive
promote
healing
highly
appreciated.
Herein,
novel
supramolecular
poly(N-isopropylacrylamide)
hybrid
hydrogel
composed
of
quaternized
chitosan-graft-β-cyclodextrin,
adenine,
polypyrrole
nanotubes
via
host-guest
interaction
hydrogen
bonds
is
developed.
The
demonstrates
thermal
contraction
47%
remaining
area
after
2
h
at
37
℃
adhesion
5.74
kPa,
which
essential
multiple
mechanical
biological
properties
including
suitable
properties,
self-healing,
on-demand
removal,
antioxidant,
hemostasis,
photothermal/intrinsic
antibacterial
activity
(higher
99%
killing
ratio
within
5
min
irradiation).
In
both
full-thickness
skin
incision
excision
models,
reveals
significant
24
post-surgery.
acute
methicillin-resistant
Staphylococcus
aureus-infected
assays,
wounds
treated
with
demonstrate
enhanced
rapid
rate,
mild
inflammatory
response,
advanced
angiogenesis,
well-arranged
collagen
fibers.
Altogether,
results
indicate
promising
synchronously
healing.
Analytical Chemistry,
Journal Year:
2021,
Volume and Issue:
93(19), P. 7355 - 7361
Published: May 6, 2021
A
facile
strategy
for
the
electrochemical
detection
of
human
epidermal
growth
factor
receptor
2
(HER2),
a
breast
cancer
biomarker,
was
presented
via
fabrication
an
antifouling
sensing
interface
based
on
conducting
polymer
poly(3,4-ethylenedioxythiophene)
(PEDOT)
and
biocompatible
peptide
hydrogel.
The
hydrogel
prepared
from
designed
short
Phe-Glu-Lys-Phe
functionalized
with
fluorene
methoxycarbonyl
group
(Fmoc-FEKF)
enabled
excellent
activity
preservation
immobilized
biomolecules,
its
good
hydrophilicity
facilitated
effective
alleviation
nonspecific
adsorption
or
biofouling,
while
PEDOT
film
provided
highly
stable
substrate.
developed
biosensor
sensitive
selective
HER2
detection,
wide
linear
response
range
0.1
ng
mL–1
to
1.0
μg
low
limit
45
pg
mL–1.
Moreover,
feasible
use
complex
biological
samples,
it
capable
detecting
in
serum
clinically
acceptable
accuracy,
manifesting
promising
potential
practical
application.
Chemistry - An Asian Journal,
Journal Year:
2022,
Volume and Issue:
17(9)
Published: March 19, 2022
Self-assembly
of
supramolecular
hydrogels
is
driven
by
dynamic,
non-covalent
interactions
between
molecules.
Considerable
research
effort
has
been
exerted
to
fabricate
and
optimise
that
display
shear-thinning,
self-healing,
reversibility,
in
order
develop
materials
for
biomedical
applications.
This
review
provides
a
detailed
overview
the
chemistry
behind
dynamic
physicochemical
sustain
hydrogel
formation
(hydrogen
bonding,
hydrophobic
interactions,
ionic
metal-ligand
coordination,
host-guest
interactions).
Novel
design
strategies
methodologies
create
are
highlighted,
which
offer
promise
wide
range
applications,
specifically
drug
delivery,
wound
healing,
tissue
engineering
3D
bioprinting.
To
conclude,
future
prospects
briefly
discussed,
consideration
given
steps
required
ultimately
bring
these
biomaterials
into
clinical
settings.
