Photoacoustic Imaging and Photothermal Therapy of Semiconducting Polymer Nanoparticles: Signal Amplification and Second Near‐Infrared Construction

Small, Journal Year: 2021, Volume and Issue: 17(6)

Published: Jan. 15, 2021

Photoacoustic (PA) imaging and photothermal therapy (PTT) have attracted extensive attention in disease diagnosis treatment. Although many exogenous contrast agents been developed for PA PTT, the design guidelines to amplify their performances remain challenging are highly demanded. Semiconducting polymer nanoparticles (SPNs) composed of polymers with π-electron delocalized backbones can be designed PTT performance, because clear structure-property relation versatility modifying molecular structures tune photophysical properties. This review summarizes recent advances photoacoustic applications semiconducting a focus on signal amplification second near-infrared (NIR-II, 1000-1700 nm) construction. The strategies such as screening, fluorescence quenching, accelerated heat dissipation, size-dependent dissipation first discussed brightness SPNs vivo PA. approaches shifting absorption NIR-II then introduced so improve tissue penetration depth therapy. At last, current challenges perspectives field discussed.

Language: Английский

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Organic Photodynamic Nanoinhibitor for Synergistic Cancer Therapy

Angewandte Chemie International Edition, Journal Year: 2019, Volume and Issue: 58(24), P. 8161 - 8165

Published: April 17, 2019

Despite its great potential in cancer treatment, photodynamic therapy (PDT) often exacerbates hypoxia and subsequently compromises therapeutic efficacy. To overcome this issue, an organic nanoinhibitor (OPNi) has been synthesized that the additional ability to counteract carbonic anhydrase IX (CA-IX), a molecular target hypoxia-mediated signalling cascade. OPNi is composed of metabolizable semiconducting polymer as photosensitizer CA-IX antagonist conjugated amphiphilic matrix. This structure allows not only selectively bind positive cells facilitate tumor accumulation but also regulate CA-IX-related pathway. The integration inhibition into targeted PDT process eventually synergistic effect, leading superior antitumor efficacy over alone, well reduced probability hypoxia-induced metastasis. study thus proposes strategy devise simple yet amplified photosensitizers conquer pitfalls traditional PDT.

Language: Английский

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Metformin-Induced Stromal Depletion to Enhance the Penetration of Gemcitabine-Loaded Magnetic Nanoparticles for Pancreatic Cancer Targeted Therapy

Journal of the American Chemical Society, Journal Year: 2020, Volume and Issue: 142(10), P. 4944 - 4954

Published: Feb. 18, 2020

Pancreatic ductal adenocarcinoma, as one of the most aggressive cancers, is characterized by rich desmoplastic stroma that forms a physical barrier for anticancer drugs. To address this issue, we herein report two-step sequential delivery strategy targeted therapy pancreatic cancer with gemcitabine (GEM). In strategy, metformin (MET) was first administrated to disrupt dense stroma, based on fact MET downregulated expression fibrogenic cytokine TGF-β suppress activity stellate cells (PSCs), through 5′-adenosine monophosphate-activated protein kinase pathway PANC-1 cells. consequence, PSC-mediated reactions generating α-smooth muscle actin and collagen were inhibited, which promoted GEM pH (low) insertion peptide (pHLIP) comodified magnetic nanoparticles (denoted GEM-MNP-pHLIP). addition, pHLIP largely increased binding affinity nanodrug The effective accumulation MET/GEM-MNP-pHLIP in vivo confirmed resonance imaging enhanced underlying nanoparticles. tumor growth inhibition GEM-MNP-pHLIP treatment investigated both subcutaneous orthotopic mice models. A remarkably improved therapeutic efficacy, example, up 91.2% ratio over 30 d treatment, well-exemplified novel cascade innovative use MET.

Language: Английский

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A Polymer Multicellular Nanoengager for Synergistic NIR‐II Photothermal Immunotherapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(14)

Published: Feb. 26, 2021

Abstract Cell‐membrane‐coated nanoparticles (CCNPs) that integrate the biophysiological advantages of cell membranes with multifunctionalities synthetic materials hold great promise in cancer immunotherapy. However, strategies have yet to be revealed further improve their immunotherapeutic efficacy. Herein, a polymer multicellular nanoengager (SPNE) for synergistic second‐near‐infrared‐window (NIR‐II) photothermal immunotherapy is reported. The consists an NIR‐II absorbing as core, which camouflaged fused derived from immunologically engineered tumor cells and dendritic (DCs) vaccine shell. In association high accumulation lymph nodes tumors, engagement ability SPNE enables effective cross‐interactions among cells, DCs, T leading augmented activation relative bare or tumor‐cell‐coated nanoparticles. Upon deep‐tissue penetrating photoirradiation, eradicates induces immunogenic death, eliciting anti‐tumor immunity. Such effect eventually inhibits growth, prevents metastasis procures immunological memory. Thus, this study presents general cell‐membrane‐coating approach develop photo‐immunotherapeutic agents therapy.

Language: Английский

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Near‐Infrared Photoactivatable Semiconducting Polymer Nanoblockaders for Metastasis‐Inhibited Combination Cancer Therapy

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(46)

Published: Sept. 30, 2019

Inhibition of protein biosynthesis is a promising strategy to develop new therapeutic modalities for cancers; however, noninvasive precise regulation this cellular event in living systems has been rarely reported. In study, semiconducting polymer nanoblockader (SPNB ) developed that can inhibit intracellular synthesis upon near-infrared (NIR) photoactivation synergize with photodynamic therapy (PDT) metastasis-inhibited cancer therapy. SPNB self-assembled from an amphiphilic which grafted poly(ethylene glycol) conjugated blockader through singlet oxygen (1 O2 cleavable linker. Such designed molecular structure not only enables generation 1 under NIR photoirradiation PDT, but also permits blockaders terminate translation. Thereby, exerts synergistic action afford enhanced efficacy tumor ablation. More importantly, -mediated inhibition precisely and remotely downregulates the expression levels metastasis-related proteins tissues, eventually contributing complete lung metastasis. This study thus proposes photoactivatable protherapeutic design

Language: Английский

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