The Unprecedented Biodegradable Polyzwitterion: A Removal‐Free Patch for Accelerating Infected Diabetic Wound Healing DOI
Zhuoya Wang, Danyang Chen, Hongying Wang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(30)

Published: May 12, 2024

Zwitterionic polymers have emerged as an important class of biomaterials to construct wound dressings and antifouling coatings over the past decade due their excellent hydrophilicity. However, all reported zwitterionic are nondegradable because noncleavable carbon─carbon bonding backbones, must be removed periodically after treatment avoid hypoxia in wound, thus leading potential secondary injury. In this work, a biodegradable polyzwitterion patch is fabricated for first time by ring-opening polymerization carboxybetaine dithiolane (CBDS), which self-crosslinked via inter-amide hydrogen bonds dipole-dipole interactions on side chains. The unprecedented polyCBDS (PCBDS) demonstrates enough ductility owing intermolecular physical fully cover irregular wounds, also showing biodegradability performance resulted from existence disulfide groups. Besides, PCBDS degradation-induced released CBDS owns potent antioxidant antibacterial activities. This used diabetic dressing, inhibiting bacterial adhesion external surface, its degradation products can exactly kill bacteria scavenge excessive reactive oxygen species (ROS) at site regulate local microenvironment, including regulation cytokine express macrophage polarization, accelerating infected repair, avoiding

Language: Английский

A Coenzyme‐Based Deep Eutectic Supramolecular Polymer Bioadhesive DOI Open Access
Chunyan Cui, Yage Sun,

Xiongfeng Nie

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(49)

Published: July 19, 2023

Abstract α‐lipoic acid (LA), a coenzyme, has proved to have excellent antioxidant and antibacterial activities; however, its intrinsic hydrophobicity metastability of polyLA remains major challenge for the application LA‐based bulk materials in biomedical field. Herein, self‐stabilized deep eutectic supramolecular polymer ( LA‐DESP) adhesive is created by one‐step heating mixture LA sodium α‐lipoate (LA‐Na) (S‐, R‐isomer, racemate) without introducing any exogenous stabilizing molecules. The underlying effect LA/LA‐Na unveiled be originated from multiple hydrogen bonds between polyLA‐Na, which not only prevent depolymerization but also lower melting point LA‐DESP near body pathological temperature. Copolymerization LA‐Na slows down dissociation thus affording sustainable release bioactive small molecules satisfactory functions. Also, exhibits fast tough adhesion diverse substrates, including wet tissues, relying on situ curing property rich carboxyl groups. explored as tissue sealant, can well replace surgical suture enhance wound healing skin incision rat model. unprecedented will provide new strategy development bioadhesives.

Language: Английский

Citations

52
New Advances in Covalent Network Polymers via Dynamic Covalent Chemistry DOI
Zepeng Lei, Hongxuan Chen, Shaofeng Huang

et al.

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(12), P. 7829 - 7906

Published: June 3, 2024

Covalent network polymers, as materials composed of atoms interconnected by covalent bonds in a continuous network, are known for their thermal and chemical stability. Over the past two decades, these have undergone significant transformations, gaining properties such malleability, environmental responsiveness, recyclability, crystallinity, customizable porosity, enabled development integration dynamic chemistry (DCvC). In this review, we explore innovative realm polymers focusing on recent advances achieved through application DCvC. We start examining history fundamental principles DCvC, detailing its inception core concepts noting key role reversible bond formation. Then reprocessability DCvC is thoroughly discussed, starting from milestones that marked evolution progressing to current trends applications. The influence crystallinity then reviewed, covering diversity, synthesis techniques, functionalities. concluding section, address challenges faced field speculates potential future directions.

Language: Английский

Citations

52
Emerging Hydrogen-Bond Design for High-Performance Dynamic Polymeric Materials DOI
Yuanxin Deng, Qi Zhang, Da‐Hui Qu

et al.

ACS Materials Letters, Journal Year: 2023, Volume and Issue: 5(2), P. 480 - 490

Published: Jan. 13, 2023

The hydrogen bond, one of the simplest and most versatile noncovalent interactions, is essential for many dynamic functions in living systems. After long-term fundamental development, H-bond chemistry has been well established, with a large family molecular moieties tunable binding affinities available. In past several years, growing interest polymeric materials aroused series emerging applications material design. This Perspective aims at discussing design principles H-bond-based by summarizing state art recently emerged materials. Opportunities challenges are proposed to provide an overview this research topic, possible future directions, potential applications.

Language: Английский

Citations

42
Covalent Adaptable Networks with Dual Dynamic Covalent Bonds for Self‐Repairing Infrared Transmitting Materials DOI
Chenhui Cui, Fang Wang, Xingxing Chen

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(24)

Published: Feb. 12, 2024

Abstract Infrared transmitting materials (IRTMs) are prone to mechanical and corrosion damage during long‐time exposure harsh outside environments. However, conventional IRTMs frequently lack self‐repairability that limit their lifespan. To address the limitation, thioctic acid‐based epoxy resins (TAEs) developed from natural acid commercial monomers. The double ring‐opening polymerization (ROP) reactions of groups result in dual dynamic covalent bonds with varying bond energies containing relatively weak disulfide strong ester bonds. As compared adaptable networks (CANs) present rapid creep properties when heated, TAEs maintain geometric stability self‐repairing at a mild temperature 80 °C by enhancing network integrity through stable crosslinking points. feature renders capability while maintaining precise geometrical dimensions, which is suitable for infrared devices. On other hand, exhibit high near‐infrared transmittance (>80%). Therefore, demonstrate they can be used as superior polymeric IRTM.

Language: Английский

Citations

33
The Unprecedented Biodegradable Polyzwitterion: A Removal‐Free Patch for Accelerating Infected Diabetic Wound Healing DOI
Zhuoya Wang, Danyang Chen, Hongying Wang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(30)

Published: May 12, 2024

Zwitterionic polymers have emerged as an important class of biomaterials to construct wound dressings and antifouling coatings over the past decade due their excellent hydrophilicity. However, all reported zwitterionic are nondegradable because noncleavable carbon─carbon bonding backbones, must be removed periodically after treatment avoid hypoxia in wound, thus leading potential secondary injury. In this work, a biodegradable polyzwitterion patch is fabricated for first time by ring-opening polymerization carboxybetaine dithiolane (CBDS), which self-crosslinked via inter-amide hydrogen bonds dipole-dipole interactions on side chains. The unprecedented polyCBDS (PCBDS) demonstrates enough ductility owing intermolecular physical fully cover irregular wounds, also showing biodegradability performance resulted from existence disulfide groups. Besides, PCBDS degradation-induced released CBDS owns potent antioxidant antibacterial activities. This used diabetic dressing, inhibiting bacterial adhesion external surface, its degradation products can exactly kill bacteria scavenge excessive reactive oxygen species (ROS) at site regulate local microenvironment, including regulation cytokine express macrophage polarization, accelerating infected repair, avoiding

Language: Английский

Citations

27