Singlet oxygen: Properties, generation, detection, and environmental applications

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 461, P. 132538 - 132538

Published: Sept. 13, 2023

Language: Английский

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Photodecaging of a Mitochondria-Localized Iridium(III) Endoperoxide Complex for Two-Photon Photoactivated Therapy under Hypoxia

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(9), P. 4091 - 4101

Published: Feb. 16, 2022

Despite the clinical success of photodynamic therapy (PDT), application this medical technique is intrinsically limited by low oxygen concentrations found in cancer tumors, hampering production therapeutically necessary singlet (1O2). To overcome limitation, we report on a novel mitochondria-localized iridium(III) endoperoxide prodrug (2-O-IrAn), which, upon two-photon irradiation NIR, synergistically releases highly cytotoxic complex (2-IrAn), oxygen, and an alkoxy radical. 2-O-IrAn was to be (photo-)toxic hypoxic tumor cells multicellular spheroids (MCTS) nanomolar range. provide selectivity improve pharmacological properties 2-O-IrAn, it encapsulated into biotin-functionalized polymer. The generated nanoparticles were nearly fully eradicate inside mouse model within single treatment. This study presents, best our knowledge, first example iridium(III)-based for synergistic therapy/photoactivated chemotherapy, opening up new avenues treatment tumors.

Language: Английский

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Photodynamic therapy: Innovative approaches for antibacterial and anticancer treatments

Medicinal Research Reviews, Journal Year: 2023, Volume and Issue: 43(4), P. 717 - 774

Published: Feb. 9, 2023

Abstract Photodynamic therapy is an alternative treatment mainly for cancer but also bacterial infections. This dates back to 1900 when a German medical school graduate Oscar Raab found photodynamic effect while doing research his doctoral dissertation with Professor Hermann von Tappeiner. Unexpectedly, revealed that the toxicity of acridine on paramecium depends intensity light in laboratory. therefore based administration photosensitizer subsequent irradiation within absorption maxima this substance followed by reactive oxygen species formation and finally cell death. Although not novelty, there endeavor various modifications therapy. For example, selectivity efficiency photosensitizer, as well types sources are still being modified improve final results The main aim review summarize anticancer antibacterial modifications, namely compounds, approaches, techniques, enhance effectiveness

Language: Английский

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Enhancing Fractionated Cancer Therapy: A Triple-Anthracene Photosensitizer Unleashes Long-Persistent Photodynamic and Luminous Efficacy

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(9), P. 6252 - 6265

Published: Feb. 20, 2024

Conventional photodynamic therapy (PDT) is often limited in treating solid tumors due to hypoxic conditions that impede the generation of reactive oxygen species (ROS), which are critical for therapeutic efficacy. To address this issue, a fractionated PDT protocol has been suggested, wherein light irradiation administered stages separated by dark intervals permit recovery during these breaks. However, current photosensitizers used incapable sustaining ROS production intervals, leading suboptimal outcomes (Table S1). circumvent drawback, we have synthesized novel photosensitizer based on triple-anthracene derivative designed prolonged generation, even after cessation exposure. Our study reveals unique action derivatives, facilitating direct and effective disruption biomolecules significantly improving efficacy S2). Moreover, existing lack imaging capabilities monitoring, constraints fine-tuning parameters also serves as an afterglow agent, emitting sustained luminescence postirradiation. This function allows precise optimization between sessions aids determining timing subsequent irradiation, thus enabling meticulous control over parameters. Utilizing our photosensitizer, formulated regimen effectively eliminates orthotopic pancreatic tumors. investigation highlights promise employing long-persistent activity advanced approaches overcome limitations tumor treatment.

Language: Английский

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A comprehensive review on singlet oxygen generation in nanomaterials and conjugated polymers for photodynamic therapy in the treatment of cancer

Nanoscale, Journal Year: 2024, Volume and Issue: 16(7), P. 3243 - 3268

Published: Jan. 1, 2024

Photodynamic Therapy (PDT): A minimally invasive treatment for a range of benign disorders and malignancies.

Language: Английский

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Supramolecular Coordination Complexes for Synergistic Cancer Therapy

Accounts of Chemical Research, Journal Year: 2024, Volume and Issue: 57(8), P. 1174 - 1187

Published: April 1, 2024

ConspectusSupramolecular coordination complexes (SCCs) are predictable and size-tunable supramolecular self-assemblies constructed through directional bonds between readily available organic ligands metallic receptors. Based on planar 3D structures, SCCs can be mainly divided into two categories: metallacycles (e.g., rhomboidal, triangular, rectangular, hexagonal) metallacages tetrahedral, hexahedral, dodecahedral). The enable the efficient formation of with well-defined architectures geometries. exhibit several advantages, including good directionality, strong interaction force, tunable modularity, solution processability, making them highly attractive for biomedical applications, especially in cellular imaging cancer therapy. Compared their molecular precursors, demonstrate enhanced uptake a strengthened tumor accumulation effect, owing to inherently charged structures. These properties chemotherapeutic potential inherent platinum have promoted widespread application antitumor Furthermore, defined structures SCCs, achieved via design modification assembly elements introduction different functional groups, combat malignant tumors multipronged treatment modalities. Because development cancer-treatment methodologies integrated clinics has evolved from single-modality chemotherapy synergistic multimodal therapy, therapy is crucial. While some pioneering reviews explored bioapplications often categorized by specific function or focusing metal ligand types, comprehensive exploration multifunctionality critical gap current literature.In this Account, we focus platinum-based applications other metals, such as Pd-, Rh-, Ru-, Ir-based been Therrien Casini et al., garnered significant interest, unique advantages which enhance efficacy, considered prominent candidates therapies desirable properties, potent activity, exceptionally low systemic toxicity, active tumor-targeting ability, uptake. diverse diagnostic therapeutic modalities chemotherapy, photothermal photodynamic therapy) single platform based Consequently, herein, summarize our recent research particular emphasis cooperative interplay methods. In Conclusions section, present key advancements basis findings propose future directions that may significantly impact field.

Language: Английский

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Self-Assembly of Enantiopure Pd₁₂ Tetrahedral Homochiral Nanocages with Tetrazole Linkers and Chiral Recognition

Journal of the American Chemical Society, Journal Year: 2020, Volume and Issue: 142(19), P. 9070 - 9078

Published: April 21, 2020

Enantiopure acceptors (R,R)M and (S,S)M [where M = (N1,N1,N2,N2-tetramethylcyclohexane-1,2-diamine)Pd(NO3)2] have been used to design enantiopure Pd(II) tetrahedral cages. Self-assembly of [1,4-di(1H-tetrazol-5-yl)benzene] (H2L1) with chiral yielded homochiral cages (ΛΛΛΛ)T1 (ΔΔΔΔ)T1, respectively. This strategy was further extended by using [2,6-di(1H-tetrazol-5-yl)naphthalene] (H2L2) obtain water-soluble nanocages (ΛΛΛΛ)T2 (ΔΔΔΔ)T2, In order assembly a larger cavity for potential use in enantioselective recognition, [4,4'-di(1H-tetrazol-5-yl)-1,1'-biphenyl] (H2L3) as the linker, which also resulted formation (ΛΛΛΛ)T3 (ΔΔΔΔ)T3 upon treatment (S,S)M, The present represent unusual examples square-planar metal ions. Finally, T3 employed host-guest study they offer largest hydrophobic cavity. Encapsulation guest molecules such [(R/S)-1,1'-binaphthalene]-2,2'-diol] (B) [(R/S)-2,2'-diethoxy-1,1'-binaphthalene] (EtB) has performed successfully establish asymmetric nature enantiopurity host showed certain selectivity toward one enantiomer over other. preferred R-EtB S-EtB (75:25) because better fitting within (Λ/R pair), whereas favored instead (Δ/S pair ratio 73:27) similar selectivity.

Language: Английский

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Rotaxane-Branched Dendrimers with Enhanced Photosensitization

Journal of the American Chemical Society, Journal Year: 2020, Volume and Issue: 142(39), P. 16748 - 16756

Published: Sept. 1, 2020

During the past few decades, fabrication of functional rotaxane-branched dendrimers has become one most attractive yet challenging topics within supramolecular chemistry and materials science. Herein, we present successful a family new containing up to 21 platinum atoms 42 photosensitizer moieties through an efficient controllable divergent approach. Notably, photosensitization efficiencies these gradually increased with increase dendrimer generation. For example, third-generation PG3 revealed 13.3-fold higher 1O2 generation efficiency than its corresponding monomer AN. The enhanced was attributed enhancement intersystem crossing (ISC) simple incorporation multiple heavy on axles wheels rotaxane units, respectively, which been validated by UV-visible fluorescence techniques, time-dependent density theory calculations, photolysis model reactions, apparent activation energy calculations. Therefore, develop promising platform for preparation effective photosensitizers.

Language: Английский

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Self-assembled metallasupramolecular cages towards light harvesting systems for oxidative cyclization

Chemical Science, Journal Year: 2021, Volume and Issue: 12(14), P. 5319 - 5329

Published: Jan. 1, 2021

Designing artificial light harvesting systems with the ability to utilize output energy for fruitful application in aqueous medium is an intriguing topic development of clean and sustainable energy. We report here facile synthesis three prismatic molecular cages as imminent supramolecular optoelectronic materials via two-component coordination-driven self-assembly a new tetra-imidazole donor (L) combination 180°/120° di-platinum(ii) acceptors. Self-assembly 180° trans-Pt(ii) acceptors A1 A2 L leads formation Pt4 2(1a) Pt8 2(2a) respectively, while 120°-Pt(ii) acceptor A3 gives 2(3a) metallacage. PF6 - analogues (1b, 2b 3b) metallacages possess high molar extinction coefficient large Stokes shift. 1b-3b are weakly emissive dilute solution but showed aggregation induced emission (AIE) water/MeCN mixture well solid state. AIE active 3b (90% mixture) act donors fabricating Förster resonance transfer (FRET) organic dye rhodamine-B (RhB) efficiency good antenna effect. The represent interesting platform fabricate generation Finally, harvested LHSs (2b + RhB) (3b was utilized successfully efficient visible photo-oxidative cross coupling cyclization N,N-dimethylaniline (4) series N-alkyl/aryl maleimides (5) acetonitrile dramatic enhancement yields compared reactions RhB or alone.

Language: Английский

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Regulation of excitons dissociation in AgI/Bi3O4Br for advanced reactive oxygen species generation towards photodegradation

Applied Catalysis B Environment and Energy, Journal Year: 2021, Volume and Issue: 285, P. 119820 - 119820

Published: Jan. 3, 2021

Language: Английский

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