Luminescent and Photofunctional Transition Metal Complexes: From Molecular Design to Diagnostic and Therapeutic Applications

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(32), P. 14420 - 14440

Published: Aug. 4, 2022

There has been emerging interest in the exploitation of photophysical and photochemical properties transition metal complexes for diagnostic therapeutic applications. In this Perspective, we highlight major recent advances development luminescent photofunctional complexes, particular, those rhenium(I), ruthenium(II), osmium(II), iridium(III), platinum(II), as bioimaging reagents phototherapeutic agents, with a focus on molecular design strategies that harness modulate interesting behavior complexes. We also discuss current challenges future outlook both fundamental research clinical

Language: Английский

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Recent advances in noble metal complex based photodynamic therapy

Chemical Science, Journal Year: 2022, Volume and Issue: 13(18), P. 5085 - 5106

Published: Jan. 1, 2022

This minireview summarizes recent developments of noble metal photosensitizers based on Ru, Ir, and Pt. Molecular design strategies to overcome shallow tissue penetration depth, O 2 -dependence the limited therapeutic effect are introduced.

Language: Английский

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Organometallic anti-tumor agents: targeting from biomolecules to dynamic bioprocesses

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(8), P. 2790 - 2832

Published: Jan. 1, 2023

Organometallics act through specific biomolecular targets or tumor homeostasis perturbation to induce various cell death pathways.

Language: Английский

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Near-infrared metal agents assisting precision medicine: from strategic design to bioimaging and therapeutic applications

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(13), P. 4392 - 4442

Published: Jan. 1, 2023

Metal agents have made incredible strides in preclinical research and clinical applications, but their short emission/absorption wavelengths continue to be a barrier distribution, therapeutic action, visual tracking, efficacy evaluation.

Language: Английский

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A Near‐Infrared Light‐Activated Photocage Based on a Ruthenium Complex for Cancer Phototherapy

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(24)

Published: March 9, 2023

Conventional photocages only respond to short wavelength light, which is a significant obstacle developing efficient phototherapy in vivo. The development of activated by near-infrared (NIR) light at wavelengths from 700 950 nm important for vivo studies but remains challenging. Herein, we describe the synthesis photocage based on ruthenium (Ru) complex with NIR light-triggered photocleavage reaction. commercial anticancer drug, tetrahydrocurcumin (THC), was coordinated RuII center create Ru-based that readily responsive 760 nm. inherited properties THC. As proof-of-concept, further engineered self-assembled photocage-based nanoparticle system amphiphilic block copolymers. Upon exposure nm, Ru complex-based were released polymeric nanoparticles and efficiently inhibited tumor proliferation

Language: Английский

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A Metal‐Free Mesoporous Carbon Dots/Silica Hybrid Type I Photosensitizer with Enzyme‐Activity for Synergistic Treatment of Hypoxic Tumor

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(25)

Published: March 10, 2023

Abstract As a less O 2 ‐dependent photodynamic therapy (PDT), type I PDT is an effective approach to overcome the hypoxia‐induced low efficiency against solid tumors. However, commonly used metal‐involved agents suffer from long‐term biosafety concern. Herein, metal‐free photosensitizer, N ‐doped carbon dots/mesoporous silica nanoparticles (NCDs/MSN, ≈40 nm) nanohybrid with peroxidase (POD)‐like activity for synergistic and enzyme‐activity treatment, developed on gram scale via facile one‐pot strategy through mixing source precursor assistance of template. Benefiting narrow bandgap (1.92 eV) good charge separation capacity NCDs/MSN, upon 640 nm light irradiation, excited electrons in conduction band can effectively generate •− by reduction dissolved one‐electron transfer process even under hypoxic conditions, inducing apoptosis tumor cells. Moreover, photoinduced partially transform into more toxic • OH two‐electron reduction. POD‐like NCDs/MSN catalyze endogenous H microenvironment, further synergistically ablating 4T1 Therefore, mass production way synthesize novel photosensitizer enzyme‐mimic treatment tumors provided, which exhibits promising clinical translation prospects.

Language: Английский

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Engineered Bacteria Labeled with Iridium(III) Photosensitizers for Enhanced Photodynamic Immunotherapy of Solid Tumors

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(43)

Published: Sept. 5, 2023

Despite metal-based photosensitizers showing great potential in photodynamic therapy for tumor treatment, the application of is intrinsically limited by their poor cancer-targeting properties. Herein, we reported a photosensitizer-bacteria hybrid, Ir-HEcN, via covalent labeling an iridium(III) photosensitizer to surface genetically engineered bacteria. Due its intrinsic self-propelled motility and hypoxia tropism, Ir-HEcN selectively targets penetrates deeply into tissues. Importantly, capable inducing pyroptosis immunogenic cell death cells under irradiation, thereby remarkably evoking anti-tumor innate adaptive immune responses vivo leading regression solid tumors combinational immunotherapy. To best our knowledge, first metal complex decorated bacteria enhanced

Language: Английский

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Exosome camouflaged coordination-assembled Iridium(III) photosensitizers for apoptosis-autophagy-ferroptosis induced combination therapy against melanoma

Biomaterials, Journal Year: 2023, Volume and Issue: 301, P. 122212 - 122212

Published: June 24, 2023

Language: Английский

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Metallopolymer strategy to explore hypoxic active narrow-bandgap photosensitizers for effective cancer photodynamic therapy

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 2, 2024

Abstract Practical photodynamic therapy calls for high-performance, less O 2 -dependent, long-wavelength-light-activated photosensitizers to suit the hypoxic tumor microenvironment. Iridium-based exhibit excellent photocatalytic performance, but in vivo applications are hindered by conventional -dependent Type-II photochemistry and poor absorption. Here we show a general metallopolymerization strategy engineering iridium complexes exhibiting Type-I enhancing absorption intensity blue near-infrared region. Reactive oxygen species generation of metallopolymer Ir-P1 , where atom is covalently coupled polymer backbone, over 80 times higher than that its mother without under 680 nm irradiation. This also works effectively when directly included ( Ir-P2 ) backbones, wide generality. The nanoparticles efficient •− conjugated with integrin αvβ3 binding cRGD achieve targeted therapy.

Language: Английский

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“Three birds with one stone” nanoplatform: Efficient near‐infrared‐triggered type‑I AIE photosensitizer for mitochondria‐targeted photodynamic therapy against hypoxic tumors

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: March 24, 2024

Abstract Currently three major problems seriously limit the practical application of cancer photodynamic therapy (PDT): (i) hypoxic tumor microenvironment (TME); (ii) low generation efficiency toxic reactive oxygen species (ROS) in aggregates and (iii) shallow tissue penetration depth excitation light. Very limited approaches are available for addressing all above with a single design. Herein, rational “three birds one stone” molecular nanoengineering strategy is demonstrated: nanoplatform U‐Ir@PAA‐ABS based on covalent combination lanthanide‐doped upconversion nanoparticles (UCNPs) an AIE‐active dinuclear Ir(III) complex provides concentration‐dependent type‐I photochemical process upon 980 nm irradiation by Föster resonance energy transfer (FRET). targets mitochondria has excellent phototoxicity even severe hypoxia environments irradiation, inducing dual‐mode cell death mechanism apoptosis ferroptosis. Taken together, vitro vivo results demonstrate successful improving efficacy PDT against tumors.

Language: Английский

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