Microsystems & Nanoengineering,
Journal Year:
2017,
Volume and Issue:
3(1)
Published: Jan. 2, 2017
Abstract
Mapping
brain
activity
has
received
growing
worldwide
interest
because
it
is
expected
to
improve
disease
treatment
and
allow
for
the
development
of
important
neuromorphic
computational
methods.
MEMS
microsystems
are
continue
offer
new
exciting
solutions
meet
need
high-density,
high-fidelity
neural
interfaces.
Herein,
state-of-the-art
in
recording
stimulation
tools
research
reviewed,
some
most
significant
technology
trends
shaping
field
neurotechnology
discussed.
Science,
Journal Year:
2018,
Volume and Issue:
362(6412), P. 319 - 324
Published: Sept. 6, 2018
Transistor
sensing
in
salt
solutions
Molecular
binding
to
receptors
on
the
surface
of
field-effect
transistors
(FETs)
can
be
sensed
through
changes
transconductance.
However,
saline
typically
used
with
biomolecules
create
an
electrical
double
layer
that
masks
any
events
occur
within
about
1
nanometer
from
surface.
Nakatsuka
et
al.
overcame
this
limitation
by
using
large,
negatively
charged
DNA
stem
loop
structures
that,
upon
ligand
binding,
cause
conformational
FET,
even
high
ionic
strength.
The
authors
demonstrate
molecules
such
as
dopamine
artificial
cerebrospinal
fluid
well
neutral
glucose
and
zwitterion
like
sphingosine-1-phosphate.
Science
,
issue
p.
319
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(6), P. 5211 - 5295
Published: March 9, 2023
Humans
rely
increasingly
on
sensors
to
address
grand
challenges
and
improve
quality
of
life
in
the
era
digitalization
big
data.
For
ubiquitous
sensing,
flexible
are
developed
overcome
limitations
conventional
rigid
counterparts.
Despite
rapid
advancement
bench-side
research
over
last
decade,
market
adoption
remains
limited.
To
ease
expedite
their
deployment,
here,
we
identify
bottlenecks
hindering
maturation
propose
promising
solutions.
We
first
analyze
achieving
satisfactory
sensing
performance
for
real-world
applications
then
summarize
issues
compatible
sensor-biology
interfaces,
followed
by
brief
discussions
powering
connecting
sensor
networks.
Issues
en
route
commercialization
sustainable
growth
sector
also
analyzed,
highlighting
environmental
concerns
emphasizing
nontechnical
such
as
business,
regulatory,
ethical
considerations.
Additionally,
look
at
future
intelligent
sensors.
In
proposing
a
comprehensive
roadmap,
hope
steer
efforts
towards
common
goals
guide
coordinated
development
strategies
from
disparate
communities.
Through
collaborative
efforts,
scientific
breakthroughs
can
be
made
sooner
capitalized
betterment
humanity.
Chemical Reviews,
Journal Year:
2015,
Volume and Issue:
116(1), P. 215 - 257
Published: Dec. 21, 2015
Nano-bioelectronics
represents
a
rapidly
expanding
interdisciplinary
field
that
combines
nanomaterials
with
biology
and
electronics
and,
in
so
doing,
offers
the
potential
to
overcome
existing
challenges
bioelectronics.
In
particular,
shrinking
electronic
transducer
dimensions
nanoscale
making
their
properties
appear
more
biological
can
yield
significant
improvements
sensitivity
biocompatibility
thereby
open
up
opportunities
fundamental
healthcare.
This
review
emphasizes
recent
advances
nano-bioelectronics
enabled
semiconductor
nanostructures,
including
silicon
nanowires,
carbon
nanotubes,
graphene.
First,
synthesis
electrical
of
these
are
discussed
context
Second,
affinity-based
nano-bioelectronic
sensors
for
highly
sensitive
analysis
biomolecules
reviewed.
studies,
nanostructures
as
transistor-based
biosensors
from
device
behavior
through
sensing
applications
future
challenges.
Third,
complex
interface
between
nanoelectronics
living
systems,
single
cells
live
animals,
is
discussion
focuses
on
representative
electrophysiology
using
nanoelectronic
devices
cellular
measurements
emerging
work
where
arrays
incorporated
within
three-dimensional
cell
networks
define
synthetic
natural
tissues.
Last,
some
exciting
discussed.
ACS Nano,
Journal Year:
2015,
Volume and Issue:
9(1), P. 696 - 707
Published: Jan. 5, 2015
Here,
we
present
a
precision
cancer
nanomedicine
based
on
Bi2S3
nanorods
(NRs)
designed
specifically
for
multispectral
optoacoustic
tomography
(MSOT)/X-ray
computed
(CT)-guided
photothermal
therapy
(PTT).
The
as-prepared
NRs
possess
ideal
effect
and
contrast
enhancement
in
MSOT/CT
bimodal
imaging.
These
features
make
them
simultaneously
act
as
"satellite"
"precision
targeted
weapon"
the
visual
guide
to
destruction
of
tumors
vivo,
realizing
effective
tumor
metastasis
inhibition
after
intravenous
injection.
In
addition,
toxicity
screening
confirms
that
have
well
biocompatibility.
This
triple-modality-nanoparticle
approach
enables
precise
therapeutic
monitoring.
Brain Research Bulletin,
Journal Year:
2015,
Volume and Issue:
119, P. 106 - 117
Published: April 27, 2015
Spike
sorting
is
a
crucial
step
to
extract
information
from
extracellular
recordings.
With
new
recording
opportunities
provided
by
the
development
of
electrodes
that
allow
monitoring
hundreds
neurons
simultaneously,
scenario
for
generation
algorithms
both
exciting
and
challenging.
However,
this
will
require
approach
problem
common
reference
framework
quickly
assess
performance
algorithms.
In
work,
we
review
basic
concepts
spike
sorting,
including
requirements
different
applications,
together
with
problems
faced
presently
available
We
conclude
proposing
roadmap
stressing
points
be
addressed
support
neuroscientific
research
near
future.
Polymer Chemistry,
Journal Year:
2014,
Volume and Issue:
5(10), P. 3291 - 3297
Published: March 24, 2014
This
mini-review
highlights
the
latest
advances
in
chemistry
and
biology
of
Pluronic®
triblock
copolymers.
We
focus
on
their
applications
medicine,
as
drug
delivery
carriers,
biological
response
modifiers,
pharmaceutical
ingredients.
Examples
systems
formulations
currently
clinical
use,
trials
or
preclinical
development
are
highlighted.
also
discuss
role
that
copolymers
may
play
innovative
design
new
nanomedicines
near
future.
